ISMARA results: ATF6

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ATF6

Z-value: 1.50

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Transcription factors associated with ATF6

Gene Symbol	Gene ID	Gene Info
ATF6 Ensembl NCBI GeneCards UniProt	ENSG00000118217.5	activating transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF6	hg19_v2_chr1_+_161736072_161736093	0.79	3.0e-05	Click!

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

No targets for ATF6

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	8.9	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	6.7	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.3	6.3	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.2	4.8	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
1.1	4.5	GO:0036483	neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382)
1.5	4.4	GO:0051780	mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1	3.9	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	3.9	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.0	3.7	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.9	3.6	GO:0048698	negative regulation of collateral sprouting in absence of injury(GO:0048698)

Showing 1 to 10 of 155 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	10.5	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	9.5	GO:0005938	cell cortex(GO:0005938)
0.3	6.3	GO:0008385	IkappaB kinase complex(GO:0008385)
0.2	6.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.1	6.0	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.2	4.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.2	4.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	4.2	GO:0016605	PML body(GO:0016605)
0.2	4.0	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	4.0	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 87 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	8.9	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	8.4	GO:0045296	cadherin binding(GO:0045296)
0.3	6.7	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	5.8	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	5.3	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
1.5	4.4	GO:0015130	mevalonate transmembrane transporter activity(GO:0015130)
0.2	4.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.8	3.9	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1	3.6	GO:0050699	WW domain binding(GO:0050699)
0.4	3.5	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)

Showing 1 to 10 of 103 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.1	PID CDC42 PATHWAY	CDC42 signaling events
0.0	6.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	6.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	5.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	4.5	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	3.5	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	2.7	PID RAS PATHWAY	Regulation of Ras family activation
0.0	2.6	PID PLK1 PATHWAY	PLK1 signaling events
0.1	2.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	2.4	PID NECTIN PATHWAY	Nectin adhesion pathway

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	8.9	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	4.9	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.2	4.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	3.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	3.0	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	2.9	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	2.8	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	2.6	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.1	2.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	2.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions

Showing 1 to 10 of 49 entries

Results for ATF6

Z-value: 1.50

Motif logo

Transcription factors associated with ATF6

Activity-expression correlation:

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

No targets for ATF6

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: