ISMARA results: BRCA1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BRCA1

Z-value: 0.52

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Transcription factors associated with BRCA1

Gene Symbol	Gene ID	Gene Info
BRCA1 Ensembl NCBI GeneCards UniProt	ENSG00000012048.15	BRCA1 DNA repair associated

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BRCA1	hg19_v2_chr17_-_41277467_41277510	-0.35	1.4e-01	Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

No targets for BRCA1

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0060613	fat pad development(GO:0060613)
0.2	1.3	GO:0051673	membrane disruption in other organism(GO:0051673)
0.2	1.0	GO:1901545	cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.1	0.9	GO:0061034	olfactory bulb mitral cell layer development(GO:0061034)
0.1	0.8	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.2	0.7	GO:0046521	sphingoid catabolic process(GO:0046521)
0.0	0.7	GO:0090527	actin filament reorganization(GO:0090527)
0.1	0.6	GO:0001555	oocyte growth(GO:0001555)
0.0	0.6	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.1	0.5	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)

Showing 1 to 10 of 25 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0005876	spindle microtubule(GO:0005876)
0.1	0.9	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.1	0.8	GO:0000125	PCAF complex(GO:0000125)
0.0	0.6	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.5	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.5	GO:0071564	npBAF complex(GO:0071564)
0.0	0.4	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:1990075	kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)

Showing 1 to 8 of 8 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	2.3	GO:0008013	beta-catenin binding(GO:0008013)
0.1	1.3	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	1.0	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2	0.9	GO:0034602	oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0	0.8	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1	0.7	GO:0017050	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0	0.6	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.5	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.5	GO:0051010	microtubule plus-end binding(GO:0051010)

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.0	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.8	PID MYC PATHWAY	C-MYC pathway
0.7	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.0	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
1.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.9	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.7	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.7	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.4	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport

Showing 1 to 6 of 6 entries

Results for BRCA1

Z-value: 0.52

Motif logo

Transcription factors associated with BRCA1

Activity-expression correlation:

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

No targets for BRCA1

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: