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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CBFB
Z-value: 1.44
Motif logo
Transcription factors associated with CBFB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CBFB
|
ENSG00000067955.9 | core-binding factor subunit beta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CBFB | hg19_v2_chr16_+_67063855_67063873 | 0.94 | 5.3e-10 | Click! |
Activity profile of CBFB motif
Sorted Z-values of CBFB motif
Network of associatons between targets according to the STRING database.
First level regulatory network of CBFB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.7 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.6 | 5.1 | GO:0051549 | positive regulation of keratinocyte migration(GO:0051549) |
| 0.6 | 3.9 | GO:0010609 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.4 | 1.1 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.3 | 2.7 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.2 | 1.4 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.2 | 0.8 | GO:2000729 | positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
| 0.2 | 1.9 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.2 | 4.6 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.1 | 1.6 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.1 | 1.1 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.1 | 1.5 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.1 | 1.4 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.5 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 0.1 | 1.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.1 | 0.3 | GO:0050720 | interleukin-1 beta biosynthetic process(GO:0050720) |
| 0.1 | 0.6 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 0.1 | 1.0 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 2.9 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 0.7 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.1 | 3.0 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 2.1 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 3.0 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 2.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.6 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 0.0 | 0.8 | GO:0042574 | retinal metabolic process(GO:0042574) |
| 0.0 | 0.2 | GO:0097466 | protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382) |
| 0.0 | 2.2 | GO:0001755 | neural crest cell migration(GO:0001755) |
| 0.0 | 0.2 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.0 | 2.5 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.0 | 0.8 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.0 | 0.7 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 0.7 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.0 | 3.1 | GO:0006903 | vesicle targeting(GO:0006903) |
| 0.0 | 2.4 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 1.1 | GO:0010863 | positive regulation of phospholipase C activity(GO:0010863) |
| 0.0 | 1.3 | GO:0061001 | regulation of dendritic spine morphogenesis(GO:0061001) |
| 0.0 | 0.9 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.0 | 0.1 | GO:0035726 | myeloid progenitor cell differentiation(GO:0002318) common myeloid progenitor cell proliferation(GO:0035726) |
| 0.0 | 0.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0005595 | collagen type XII trimer(GO:0005595) |
| 0.1 | 1.4 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.1 | 0.7 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.1 | 1.4 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 0.5 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 0.1 | 1.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 0.8 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 0.7 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.1 | 0.3 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 0.7 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 3.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.9 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 2.4 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 0.2 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.0 | 0.7 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 1.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.4 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 6.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.4 | 1.6 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.3 | 6.7 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.3 | 3.0 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.2 | 0.9 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.2 | 1.4 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.2 | 0.8 | GO:0005502 | 11-cis retinal binding(GO:0005502) all-trans retinal binding(GO:0005503) |
| 0.1 | 2.4 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 0.8 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 0.6 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.1 | 1.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.1 | 3.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 3.0 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 1.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.7 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 0.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 0.2 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.0 | 1.4 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.8 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 2.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 3.9 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.7 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 3.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 1.4 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 1.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.4 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.0 | 2.5 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.9 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 2.1 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 1.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 2.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 4.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 2.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.5 | REACTOME ACTIVATED POINT MUTANTS OF FGFR2 | Genes involved in Activated point mutants of FGFR2 |
| 0.0 | 2.1 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.1 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.4 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 1.1 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.7 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| 0.0 | 1.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.2 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |