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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CDC5L

Z-value: 0.78

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Transcription factors associated with CDC5L

Gene Symbol Gene ID Gene Info
CDC5L
ENSG00000096401.7 cell division cycle 5 like

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CDC5Lhg19_v2_chr6_+_44355257_44355315-0.445.3e-02Click!

Activity profile of CDC5L motif

Sorted Z-values of CDC5L motif

No targets for CDC5L

Network of associatons between targets according to the STRING database.

First level regulatory network of CDC5L

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.7 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.3 GO:1903522 regulation of blood circulation(GO:1903522)
0.1 1.0 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 0.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.2 GO:1903988 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.1 0.2 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.2 GO:2000224 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.3 GO:2000006 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.1 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.2 GO:2001248 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.1 0.4 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.0 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.0 0.6 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.3 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.1 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.3 GO:0045415 negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.0 0.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.2 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.2 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.1 GO:0002879 leukocyte chemotaxis involved in inflammatory response(GO:0002232) positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 0.2 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.0 0.2 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.1 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.5 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528) sarcomerogenesis(GO:0048769)
0.0 0.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.0 0.3 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.1 GO:0031394 myoblast migration involved in skeletal muscle regeneration(GO:0014839) positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 0.1 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0 0.1 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.0 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.1 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.0 GO:0002818 intracellular defense response(GO:0002818)
0.0 0.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0 0.2 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.2 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.1 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.0 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0 0.1 GO:2000111 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.0 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:0036128 CatSper complex(GO:0036128)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.0 GO:0032127 dense core granule membrane(GO:0032127) microvesicle(GO:1990742)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0072559 NLRP3 inflammasome complex(GO:0072559)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.2 GO:0097689 iron channel activity(GO:0097689)
0.1 0.2 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
0.1 0.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.2 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.2 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.2 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.0 0.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 0.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.2 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 1.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.0 0.1 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.0 0.2 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.9 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.1 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.1 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 1.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 1.9 GO:0051087 chaperone binding(GO:0051087)
0.0 0.0 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.0 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling