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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CDX2

Z-value: 1.40

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Transcription factors associated with CDX2

Gene Symbol Gene ID Gene Info
ENSG00000165556.9 caudal type homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CDX2hg19_v2_chr13_-_28545276_28545276-0.835.5e-06Click!

Activity profile of CDX2 motif

Sorted Z-values of CDX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
1.0 3.0 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.9 2.7 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.4 4.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.4 5.3 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.4 1.9 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.4 1.1 GO:0043317 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859) regulation of cytotoxic T cell degranulation(GO:0043317) negative regulation of cytotoxic T cell degranulation(GO:0043318)
0.4 1.8 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.3 1.3 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) receptor-mediated virion attachment to host cell(GO:0046813)
0.2 1.2 GO:0031291 Ran protein signal transduction(GO:0031291)
0.2 0.7 GO:0021503 neural fold bending(GO:0021503)
0.2 2.0 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.2 4.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 0.6 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.2 1.3 GO:0051414 response to cortisol(GO:0051414)
0.1 1.6 GO:0048706 embryonic skeletal system development(GO:0048706)
0.1 0.5 GO:0002384 hepatic immune response(GO:0002384)
0.1 3.4 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 3.0 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.6 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.6 GO:0001692 histamine metabolic process(GO:0001692)
0.1 1.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.4 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533)
0.1 0.6 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 6.5 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.1 0.9 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 0.6 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1 0.1 GO:0046666 retinal cell programmed cell death(GO:0046666) regulation of retinal cell programmed cell death(GO:0046668)
0.1 0.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.2 GO:0006429 glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.5 GO:0032916 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 0.3 GO:1902304 phosphatidylserine exposure on blood platelet(GO:0097045) positive regulation of potassium ion export(GO:1902304)
0.1 0.7 GO:0070777 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.6 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.1 0.4 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.1 0.9 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 2.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.9 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.3 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 1.0 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.7 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.6 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.2 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 4.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.4 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.0 0.3 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.8 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 2.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 2.3 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 0.4 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.2 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.2 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.0 1.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.0 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 3.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.1 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.4 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.2 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.9 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 1.4 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.4 GO:0042359 vitamin D metabolic process(GO:0042359)
0.0 0.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0007286 spermatid development(GO:0007286)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 3.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.3 0.8 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 1.8 GO:1990812 growth cone filopodium(GO:1990812)
0.1 3.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.5 GO:0031592 centrosomal corona(GO:0031592)
0.1 2.0 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.6 GO:0030478 actin cap(GO:0030478)
0.1 0.5 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.8 GO:0070369 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 3.0 GO:0005605 basal lamina(GO:0005605)
0.1 0.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.5 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 3.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 2.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.6 GO:0030897 HOPS complex(GO:0030897)
0.0 0.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.6 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 1.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 1.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 5.0 GO:0005770 late endosome(GO:0005770)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0061714 folic acid receptor activity(GO:0061714)
0.4 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 0.5 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.2 2.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 1.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.2 2.0 GO:0097016 L27 domain binding(GO:0097016)
0.2 1.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 1.8 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.4 GO:1902271 D3 vitamins binding(GO:1902271)
0.1 0.4 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.3 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.6 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.1 4.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.6 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.3 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.1 3.5 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 2.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.4 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.2 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.7 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.5 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.4 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 3.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.5 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.8 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.6 GO:0089720 caspase binding(GO:0089720)
0.0 2.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.3 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.7 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.6 GO:0000150 recombinase activity(GO:0000150)
0.0 6.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.0 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 2.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 4.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID ALK1 PATHWAY ALK1 signaling events
0.1 5.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 6.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 2.1 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 4.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 2.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 1.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.7 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 3.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 2.0 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 5.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 4.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.4 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.7 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines