ISMARA results: CDX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CDX2

Z-value: 1.40

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Transcription factors associated with CDX2

Gene Symbol	Gene ID	Gene Info
CDX2 Ensembl NCBI GeneCards UniProt	ENSG00000165556.9	caudal type homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CDX2	hg19_v2_chr13_-_28545276_28545276	-0.83	5.5e-06	Click!

Activity profile of CDX2 motif

Sorted Z-values of CDX2 motif

No targets for CDX2

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.5	GO:0045824	negative regulation of innate immune response(GO:0045824)
0.4	5.3	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.4	4.3	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.2	4.2	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	4.2	GO:0016266	O-glycan processing(GO:0016266)
1.3	3.9	GO:0061713	neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.1	3.4	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	3.2	GO:0001578	microtubule bundle formation(GO:0001578)
1.0	3.0	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.1	3.0	GO:0090179	planar cell polarity pathway involved in neural tube closure(GO:0090179)

Showing 1 to 10 of 79 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	GO:0005770	late endosome(GO:0005770)
0.1	3.9	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	3.7	GO:0005720	nuclear heterochromatin(GO:0005720)
0.4	3.5	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.1	3.0	GO:0005605	basal lamina(GO:0005605)
0.9	2.7	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0	2.6	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	2.0	GO:0097025	lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	2.0	GO:0031225	anchored component of membrane(GO:0031225)
0.2	1.8	GO:1990812	growth cone filopodium(GO:1990812)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	4.4	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	4.1	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
1.0	3.9	GO:0061714	folic acid receptor activity(GO:0061714)
0.1	3.5	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.1	3.0	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	2.9	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4	2.7	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	2.7	GO:0002162	dystroglycan binding(GO:0002162)
0.1	2.6	GO:0033130	acetylcholine receptor binding(GO:0033130)

Showing 1 to 10 of 59 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	5.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	4.4	PID LKB1 PATHWAY	LKB1 signaling events
0.1	3.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	3.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.9	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	2.1	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.8	PID VEGFR1 PATHWAY	VEGFR1 specific signals

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	4.4	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	3.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.3	2.7	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.1	2.0	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	1.9	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	1.8	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	1.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.7	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts

Showing 1 to 10 of 19 entries

Results for CDX2

Z-value: 1.40

Motif logo

Transcription factors associated with CDX2

Activity-expression correlation:

Activity profile of CDX2 motif

Sorted Z-values of CDX2 motif

No targets for CDX2

Network of associatons between targets according to the STRING database.

First level regulatory network of CDX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: