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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CLOCK

Z-value: 2.47

Motif logo

Transcription factors associated with CLOCK

Gene Symbol Gene ID Gene Info
ENSG00000134852.10 clock circadian regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CLOCKhg19_v2_chr4_-_56412713_564127990.852.7e-06Click!

Activity profile of CLOCK motif

Sorted Z-values of CLOCK motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CLOCK

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0045041 B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.9 4.7 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.9 2.7 GO:0015728 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.8 2.5 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.7 6.8 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.7 2.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.6 1.9 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
0.6 1.9 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.6 3.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.6 1.8 GO:0001543 ovarian follicle rupture(GO:0001543)
0.6 0.6 GO:0009405 pathogenesis(GO:0009405)
0.5 2.5 GO:0015862 uridine transport(GO:0015862)
0.5 4.5 GO:0072553 terminal button organization(GO:0072553)
0.5 3.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.4 1.3 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.4 5.9 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.4 1.6 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.4 3.4 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.4 1.1 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.3 1.7 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.3 1.0 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.3 3.0 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.3 1.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 1.3 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.3 5.7 GO:0015816 glycine transport(GO:0015816)
0.3 2.5 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.3 4.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.3 1.2 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.3 5.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 1.5 GO:0048254 snoRNA localization(GO:0048254)
0.3 2.9 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.3 1.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.3 2.7 GO:0006552 leucine catabolic process(GO:0006552)
0.3 0.5 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.3 2.0 GO:0061198 fungiform papilla formation(GO:0061198)
0.2 1.4 GO:0006551 leucine metabolic process(GO:0006551) branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 1.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 1.3 GO:0048817 negative regulation of hair follicle maturation(GO:0048817)
0.2 1.3 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434)
0.2 0.6 GO:0048627 myoblast development(GO:0048627)
0.2 1.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 1.4 GO:0006740 NADPH regeneration(GO:0006740)
0.2 1.6 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 0.8 GO:0009956 radial pattern formation(GO:0009956)
0.2 0.8 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 0.6 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.2 0.7 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.2 0.7 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.2 2.3 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.2 2.6 GO:2000507 cap-dependent translational initiation(GO:0002191) positive regulation of energy homeostasis(GO:2000507)
0.2 0.5 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250)
0.2 2.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 0.6 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.2 1.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 0.5 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.2 1.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 0.9 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.2 1.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 0.6 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.9 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.4 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.1 2.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.4 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.1 1.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.4 GO:0000967 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.1 1.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 2.0 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 2.6 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.8 GO:0009233 menaquinone metabolic process(GO:0009233)
0.1 0.5 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.1 1.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.6 GO:0010157 response to chlorate(GO:0010157)
0.1 0.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 0.4 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.1 0.8 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.1 0.6 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 1.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.7 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.3 GO:0050894 determination of affect(GO:0050894)
0.1 2.8 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.1 2.0 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.3 GO:0015074 DNA integration(GO:0015074)
0.1 1.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 1.0 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.4 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.3 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.1 0.7 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 1.6 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.6 GO:1901907 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.7 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.8 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 2.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.9 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.8 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 2.0 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 0.4 GO:0071873 response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
0.1 0.7 GO:0032328 alanine transport(GO:0032328)
0.1 1.5 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.1 1.0 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 0.6 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 0.3 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.8 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.1 5.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.3 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.1 0.6 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 1.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.1 0.7 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.4 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 0.5 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021)
0.1 1.0 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.7 GO:0006983 ER overload response(GO:0006983)
0.1 2.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 1.5 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.1 0.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.6 GO:0098535 de novo centriole assembly(GO:0098535)
0.1 0.9 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.8 GO:1902744 negative regulation of lamellipodium assembly(GO:0010593) negative regulation of lamellipodium organization(GO:1902744)
0.1 0.8 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.8 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.8 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 1.8 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.2 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.1 0.5 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.1 0.5 GO:0009446 putrescine biosynthetic process(GO:0009446)
0.1 0.2 GO:0033685 negative regulation of luteinizing hormone secretion(GO:0033685)
0.1 1.3 GO:0006020 inositol metabolic process(GO:0006020)
0.1 3.0 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.1 1.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 1.0 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 1.3 GO:0008283 cell proliferation(GO:0008283)
0.1 0.3 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 0.8 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 1.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.9 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.1 1.3 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.1 0.5 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.2 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.1 1.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.7 GO:0000012 single strand break repair(GO:0000012)
0.1 1.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 1.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.6 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.5 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.0 0.7 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.6 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.8 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 1.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.6 GO:0007030 Golgi organization(GO:0007030)
0.0 2.1 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.6 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 1.6 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.7 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.8 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 1.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 1.0 GO:0072189 ureter development(GO:0072189)
0.0 3.5 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.1 GO:0034243 regulation of transcription elongation from RNA polymerase II promoter(GO:0034243)
0.0 0.8 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 3.0 GO:0001895 retina homeostasis(GO:0001895)
0.0 3.7 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.6 GO:0015871 choline transport(GO:0015871)
0.0 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.4 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.5 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0014870 response to muscle inactivity(GO:0014870)
0.0 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.0 4.5 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.1 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 0.6 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.3 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.6 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 0.1 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.3 GO:1903416 response to glycoside(GO:1903416)
0.0 0.3 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 1.0 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 1.7 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.4 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.0 0.7 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 1.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 2.1 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.0 0.9 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 1.4 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.0 GO:0090024 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.9 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.2 GO:0061178 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.3 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128)
0.0 0.3 GO:0032310 prostaglandin secretion(GO:0032310)
0.0 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 1.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.6 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.1 GO:2001023 regulation of response to drug(GO:2001023)
0.0 1.5 GO:0021762 substantia nigra development(GO:0021762)
0.0 0.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256) 10-formyltetrahydrofolate catabolic process(GO:0009258)
0.0 2.9 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway(GO:2001237)
0.0 1.3 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0000154 rRNA modification(GO:0000154)
0.0 0.4 GO:0044804 nucleophagy(GO:0044804)
0.0 0.9 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.6 GO:0036260 7-methylguanosine mRNA capping(GO:0006370) 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.0 0.1 GO:0045346 regulation of MHC class II biosynthetic process(GO:0045346)
0.0 0.3 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 3.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.3 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 1.5 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455)
0.0 2.6 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:0006568 tryptophan metabolic process(GO:0006568)
0.0 0.0 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.0 0.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0002440 production of molecular mediator of immune response(GO:0002440)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.3 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.4 GO:0007099 centriole replication(GO:0007099)
0.0 0.6 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 0.0 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0071344 diphosphate metabolic process(GO:0071344)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.7 6.8 GO:0070552 BRISC complex(GO:0070552)
0.7 4.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.6 5.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.4 2.7 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.4 1.2 GO:0009346 citrate lyase complex(GO:0009346)
0.4 1.1 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.4 2.3 GO:0008537 proteasome activator complex(GO:0008537)
0.3 1.3 GO:0070939 Dsl1p complex(GO:0070939)
0.3 3.0 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.3 3.5 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.3 3.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.3 1.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 1.3 GO:0097362 MCM8-MCM9 complex(GO:0097362)
0.2 0.6 GO:0034455 t-UTP complex(GO:0034455)
0.2 0.8 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 7.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 2.9 GO:0005869 dynactin complex(GO:0005869)
0.2 0.3 GO:0030686 90S preribosome(GO:0030686)
0.2 1.8 GO:0000439 core TFIIH complex(GO:0000439)
0.1 1.8 GO:0070761 pre-snoRNP complex(GO:0070761)
0.1 0.6 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.6 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.1 3.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.5 GO:1902912 pyruvate kinase complex(GO:1902912)
0.1 1.8 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.6 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.1 0.6 GO:0005606 laminin-1 complex(GO:0005606) laminin-11 complex(GO:0043260)
0.1 5.6 GO:0016592 mediator complex(GO:0016592)
0.1 0.6 GO:0098536 deuterosome(GO:0098536)
0.1 1.0 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 2.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.6 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.1 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 7.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.6 GO:0044294 dendritic growth cone(GO:0044294)
0.1 7.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.8 GO:0072487 MSL complex(GO:0072487)
0.1 0.4 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 1.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 1.0 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.1 0.4 GO:0032444 activin responsive factor complex(GO:0032444)
0.1 1.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.4 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 3.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.9 GO:0097025 lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.1 GO:0097227 sperm annulus(GO:0097227)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.9 GO:0005652 nuclear lamina(GO:0005652)
0.0 1.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.8 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.4 GO:1990812 growth cone filopodium(GO:1990812)
0.0 2.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.7 GO:0070578 RISC-loading complex(GO:0070578)
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.5 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 7.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 1.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 4.0 GO:0005796 Golgi lumen(GO:0005796)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 2.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.9 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 26.5 GO:0005730 nucleolus(GO:0005730)
0.0 5.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.9 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.8 GO:0005770 late endosome(GO:0005770)
0.0 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.5 GO:0030118 clathrin coat(GO:0030118)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0043235 receptor complex(GO:0043235)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.3 GO:0016234 inclusion body(GO:0016234)
0.0 0.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.5 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 1.7 GO:0042641 actomyosin(GO:0042641)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 4.7 GO:0005874 microtubule(GO:0005874)
0.0 3.6 GO:0005819 spindle(GO:0005819)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.0 GO:0002133 polycystin complex(GO:0002133)
0.0 0.8 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.9 5.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.8 2.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.7 3.6 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.7 6.8 GO:0004372 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.7 5.3 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.6 1.9 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.5 1.4 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.4 2.7 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.4 1.3 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.4 4.7 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.4 1.2 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.4 5.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.4 1.5 GO:0004461 lactose synthase activity(GO:0004461)
0.3 1.7 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.3 0.9 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.3 2.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3 0.8 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.3 1.6 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.3 0.8 GO:0017130 poly(C) RNA binding(GO:0017130)
0.3 2.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 2.5 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.2 1.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 1.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 1.6 GO:0005047 signal recognition particle binding(GO:0005047)
0.2 1.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 1.6 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.2 2.0 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 0.6 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.2 0.8 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.2 1.8 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 0.6 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.2 2.3 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 0.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 4.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 2.8 GO:0000182 rDNA binding(GO:0000182)
0.2 1.0 GO:0019776 Atg8 ligase activity(GO:0019776)
0.2 1.5 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 1.3 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.2 6.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 0.5 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.2 1.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.6 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.1 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 1.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 3.1 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.7 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 11.6 GO:0031491 nucleosome binding(GO:0031491)
0.1 2.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.5 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.1 0.6 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 2.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.7 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 2.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.8 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 0.8 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.1 1.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.8 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 0.3 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.8 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 1.3 GO:0004532 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.1 0.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.6 GO:0052845 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 1.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.6 GO:0039552 RIG-I binding(GO:0039552)
0.1 1.2 GO:0031386 protein tag(GO:0031386)
0.1 0.6 GO:0005119 smoothened binding(GO:0005119)
0.1 1.0 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 0.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 2.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.4 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.1 1.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 4.1 GO:0070840 dynein complex binding(GO:0070840)
0.1 3.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.5 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.1 0.6 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 0.3 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1 0.6 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 0.6 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 3.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.8 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 4.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.5 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.9 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 2.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.6 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.1 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 2.1 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.3 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 2.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.3 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.2 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.0 1.8 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 2.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.7 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 1.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 1.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.3 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 1.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.5 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.3 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 1.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 3.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 2.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 2.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.8 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 1.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:1990239 steroid hormone binding(GO:1990239)
0.0 1.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.8 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.9 GO:0015248 sterol transporter activity(GO:0015248)
0.0 2.2 GO:0004386 helicase activity(GO:0004386)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.7 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 1.4 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.0 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 1.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 0.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.8 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 6.3 GO:0045296 cadherin binding(GO:0045296)
0.0 0.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.1 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 5.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 8.4 PID AURORA B PATHWAY Aurora B signaling
0.1 10.0 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.3 PID ARF 3PATHWAY Arf1 pathway
0.1 9.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 3.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 1.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.8 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.7 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 3.1 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.8 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.0 PID ATM PATHWAY ATM pathway
0.0 0.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.7 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 1.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 5.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 2.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 4.9 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 5.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 3.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 5.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 6.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.6 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 3.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 3.6 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 1.8 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 3.0 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 1.9 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.1 2.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.1 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 0.7 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 0.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 3.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 4.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 1.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 2.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 3.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 2.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.0 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 3.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 4.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.8 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.8 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation