ISMARA results: CREB1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CREB1

Z-value: 3.44

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Transcription factors associated with CREB1

Gene Symbol	Gene ID	Gene Info
CREB1 Ensembl NCBI GeneCards UniProt	ENSG00000118260.10	cAMP responsive element binding protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CREB1	hg19_v2_chr2_+_208394658_208394692	0.70	6.1e-04	Click!

Activity profile of CREB1 motif

Sorted Z-values of CREB1 motif

No targets for CREB1

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.4	GO:0006744	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4	7.2	GO:0000733	DNA strand renaturation(GO:0000733)
0.7	6.4	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.6	5.9	GO:0060339	negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1	5.5	GO:0006400	tRNA modification(GO:0006400)
0.1	5.4	GO:0010501	RNA secondary structure unwinding(GO:0010501)
1.7	5.2	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.1	5.1	GO:0033120	positive regulation of RNA splicing(GO:0033120)
0.1	4.6	GO:0006625	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1	4.0	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)

Showing 1 to 10 of 119 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	8.7	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.2	6.4	GO:0036020	endolysosome membrane(GO:0036020)
0.1	6.2	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	6.1	GO:0016235	aggresome(GO:0016235)
1.9	5.7	GO:0075341	host cell PML body(GO:0075341)
0.0	5.3	GO:0000781	chromosome, telomeric region(GO:0000781)
0.3	5.2	GO:0008278	cohesin complex(GO:0008278)
0.1	5.2	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.1	5.0	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	4.0	GO:0035861	site of double-strand break(GO:0035861)

Showing 1 to 10 of 81 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.2	GO:0031593	polyubiquitin binding(GO:0031593)
1.0	8.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.1	8.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.2	6.4	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2	5.7	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.1	5.6	GO:0003954	NADH dehydrogenase activity(GO:0003954)
1.8	5.3	GO:0016730	ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731)
1.3	5.2	GO:0016429	tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1	4.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.2	4.0	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)

Showing 1 to 10 of 82 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.9	PID FANCONI PATHWAY	Fanconi anemia pathway
2.8	PID P73PATHWAY	p73 transcription factor network
2.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
1.8	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
1.6	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
1.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
1.0	PID TNF PATHWAY	TNF receptor signaling pathway
1.0	PID BMP PATHWAY	BMP receptor signaling
0.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.4	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	6.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	5.7	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	5.0	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription
0.0	4.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	4.0	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	3.9	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.1	3.8	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	3.6	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1	3.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis

Showing 1 to 10 of 28 entries

Results for CREB1

Z-value: 3.44

Motif logo

Transcription factors associated with CREB1

Activity-expression correlation:

Activity profile of CREB1 motif

Sorted Z-values of CREB1 motif

No targets for CREB1

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: