ISMARA results: CREB5_CREM

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CREB5_CREM_JUNB

Z-value: 1.41

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Transcription factors associated with CREB5_CREM_JUNB

Gene Symbol	Gene ID	Gene Info
CREB5 Ensembl NCBI GeneCards UniProt	ENSG00000146592.12	cAMP responsive element binding protein 5
CREM Ensembl NCBI GeneCards UniProt	ENSG00000095794.15	cAMP responsive element modulator
JUNB Ensembl NCBI GeneCards UniProt	ENSG00000171223.4	JunB proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
JUNB	hg19_v2_chr19_+_12902289_12902310	-0.94	8.9e-10	Click!
CREB5	hg19_v2_chr7_+_28725585_28725608	0.77	7.0e-05	Click!
CREM	hg19_v2_chr10_+_35484053_35484076	-0.75	1.5e-04	Click!

Activity profile of CREB5_CREM_JUNB motif

Sorted Z-values of CREB5_CREM_JUNB motif

No targets for CREB5_CREM_JUNB

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB5_CREM_JUNB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.1	GO:0031069	hair follicle morphogenesis(GO:0031069)
0.1	8.7	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.2	8.5	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2	8.5	GO:0034035	purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1	8.2	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.3	7.0	GO:0031268	pseudopodium organization(GO:0031268)
0.6	6.6	GO:0002329	pre-B cell differentiation(GO:0002329)
0.2	6.6	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.3	6.5	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	5.6	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Showing 1 to 10 of 255 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	9.8	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.2	9.6	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	7.8	GO:0031143	pseudopodium(GO:0031143)
0.0	7.1	GO:0000785	chromatin(GO:0000785)
0.1	6.8	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	6.7	GO:0005882	intermediate filament(GO:0005882)
0.0	6.4	GO:0016605	PML body(GO:0016605)
0.3	5.8	GO:0000813	ESCRT I complex(GO:0000813)
0.3	5.8	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	5.6	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)

Showing 1 to 10 of 117 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.9	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.3	8.5	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	7.4	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.9	7.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	6.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.9	6.6	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.4	6.6	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	6.4	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.1	5.4	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	5.4	GO:0003924	GTPase activity(GO:0003924)

Showing 1 to 10 of 194 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.7	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	7.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	7.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	6.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	6.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	6.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	6.3	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	5.8	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	5.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	4.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.8	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.3	8.5	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	7.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	7.4	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	7.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.3	6.5	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	6.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.4	5.4	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.2	5.4	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	5.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling

Showing 1 to 10 of 54 entries

Results for CREB5_CREM_JUNB

Z-value: 1.41

Motif logo

Transcription factors associated with CREB5_CREM_JUNB

Activity-expression correlation:

Activity profile of CREB5_CREM_JUNB motif

Sorted Z-values of CREB5_CREM_JUNB motif

No targets for CREB5_CREM_JUNB

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB5_CREM_JUNB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: