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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CREB5_CREM_JUNB

Z-value: 1.41

Motif logo

Transcription factors associated with CREB5_CREM_JUNB

Gene Symbol Gene ID Gene Info
ENSG00000146592.12 cAMP responsive element binding protein 5
ENSG00000095794.15 cAMP responsive element modulator
ENSG00000171223.4 JunB proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
JUNBhg19_v2_chr19_+_12902289_12902310-0.948.9e-10Click!
CREB5hg19_v2_chr7_+_28725585_287256080.777.0e-05Click!
CREMhg19_v2_chr10_+_35484053_35484076-0.751.5e-04Click!

Activity profile of CREB5_CREM_JUNB motif

Sorted Z-values of CREB5_CREM_JUNB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CREB5_CREM_JUNB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
1.1 3.4 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
1.1 3.2 GO:0021503 neural fold bending(GO:0021503)
0.9 2.7 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.9 2.7 GO:1902598 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.8 4.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.8 2.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.6 3.1 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.6 6.6 GO:0002329 pre-B cell differentiation(GO:0002329)
0.6 2.9 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.6 1.7 GO:0060382 regulation of DNA strand elongation(GO:0060382)
0.6 1.7 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.5 5.4 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.5 3.6 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.5 2.5 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.5 2.9 GO:0090135 actin filament branching(GO:0090135)
0.4 3.9 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.4 1.7 GO:0061582 intestinal epithelial cell migration(GO:0061582)
0.4 1.3 GO:1903452 regulation of G1 to G0 transition(GO:1903450) positive regulation of G1 to G0 transition(GO:1903452)
0.4 2.4 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.4 1.2 GO:0021896 forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.4 2.3 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.4 1.8 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.4 2.8 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.3 7.0 GO:0031268 pseudopodium organization(GO:0031268)
0.3 1.4 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.3 1.0 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.3 6.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.3 1.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.3 1.2 GO:0071684 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.3 1.4 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.3 11.1 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.3 2.2 GO:0060702 negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702)
0.3 3.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.3 1.9 GO:1903332 regulation of protein folding(GO:1903332)
0.3 1.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.3 4.0 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.3 0.8 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.3 3.1 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.3 3.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.3 0.8 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
0.2 2.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.2 3.7 GO:0061042 vascular wound healing(GO:0061042)
0.2 2.9 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 3.8 GO:0015693 magnesium ion transport(GO:0015693)
0.2 8.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 4.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 0.7 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.2 1.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 1.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.2 1.1 GO:0035617 stress granule disassembly(GO:0035617)
0.2 1.5 GO:0051012 microtubule sliding(GO:0051012)
0.2 5.2 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 0.8 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.2 1.2 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 1.2 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.2 0.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 1.4 GO:0051414 response to cortisol(GO:0051414)
0.2 1.2 GO:2001106 regulation of modification of synaptic structure(GO:1905244) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 1.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.2 2.0 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.2 3.0 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.6 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 2.8 GO:0046325 negative regulation of glucose import(GO:0046325)
0.2 8.5 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.2 1.9 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.2 6.6 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.2 0.7 GO:1990637 response to prolactin(GO:1990637)
0.2 0.3 GO:1901258 positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.2 0.5 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) negative regulation of store-operated calcium channel activity(GO:1901340)
0.2 3.2 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 0.5 GO:0042214 terpene metabolic process(GO:0042214) epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418) phytoalexin metabolic process(GO:0052314)
0.2 2.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.2 4.3 GO:0032486 Rap protein signal transduction(GO:0032486)
0.2 1.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.8 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.1 1.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 0.7 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 2.5 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 0.4 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.1 0.4 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.1 0.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 2.4 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.4 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 2.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.6 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 1.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.7 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 0.4 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.3 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.1 0.9 GO:0006642 triglyceride mobilization(GO:0006642)
0.1 0.3 GO:0006429 glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429)
0.1 0.7 GO:0072642 interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.1 0.7 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.9 GO:0007000 nucleolus organization(GO:0007000)
0.1 2.1 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 1.5 GO:0000050 urea cycle(GO:0000050)
0.1 0.4 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.4 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.1 0.7 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.0 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.1 0.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 8.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 2.4 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 0.9 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 0.6 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 1.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 2.7 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1 0.9 GO:0090487 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 1.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 3.6 GO:0042730 fibrinolysis(GO:0042730)
0.1 1.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.3 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.1 1.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.1 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.0 GO:0034214 protein hexamerization(GO:0034214)
0.1 0.7 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 4.5 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.1 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.6 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.6 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955)
0.1 5.6 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 0.7 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 1.2 GO:0061117 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of heart growth(GO:0061117)
0.1 0.8 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.4 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.3 GO:0043335 protein unfolding(GO:0043335)
0.1 8.2 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 1.7 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.1 0.3 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 1.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 0.4 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 0.7 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 1.2 GO:0010818 T cell chemotaxis(GO:0010818)
0.1 0.8 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.3 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.8 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.3 GO:0021553 olfactory nerve development(GO:0021553)
0.1 0.4 GO:0003344 pericardium morphogenesis(GO:0003344)
0.1 0.2 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.8 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 0.4 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) regulation of protein autoubiquitination(GO:1902498)
0.1 1.0 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.3 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 0.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.3 GO:2000690 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.1 1.0 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 0.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.0 2.5 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.3 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 1.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.4 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.6 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 1.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 1.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.0 1.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) positive regulation of skeletal muscle cell proliferation(GO:0014858) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.0 0.9 GO:0036315 cellular response to sterol(GO:0036315)
0.0 0.3 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.0 1.4 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.3 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.6 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.0 0.5 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.5 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.2 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.6 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 1.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.1 GO:0031081 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.0 0.9 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.5 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.7 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:1904705 regulation of vascular smooth muscle cell proliferation(GO:1904705) vascular smooth muscle cell proliferation(GO:1990874)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.4 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.6 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 1.8 GO:0033344 cholesterol efflux(GO:0033344)
0.0 0.3 GO:0021603 cranial nerve formation(GO:0021603)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.9 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:1901096 regulation of autophagosome maturation(GO:1901096)
0.0 0.5 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.3 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 1.5 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:0015871 choline transport(GO:0015871)
0.0 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.4 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 1.0 GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.5 GO:0007567 parturition(GO:0007567)
0.0 0.4 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.5 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.6 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0 0.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.3 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 2.9 GO:0070268 cornification(GO:0070268)
0.0 1.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 1.0 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.0 0.4 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.3 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 4.3 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 1.1 GO:0001947 heart looping(GO:0001947)
0.0 3.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.7 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.2 GO:0060149 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.0 1.8 GO:0007030 Golgi organization(GO:0007030)
0.0 2.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.0 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.0 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.1 GO:0033082 regulation of extrathymic T cell differentiation(GO:0033082)
0.0 0.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0006397 mRNA processing(GO:0006397)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 1.4 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.0 0.5 GO:0060976 coronary vasculature development(GO:0060976)
0.0 1.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.8 GO:0032508 DNA duplex unwinding(GO:0032508)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 9.8 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.5 1.6 GO:0075341 host cell PML body(GO:0075341)
0.4 3.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.3 4.8 GO:0000322 storage vacuole(GO:0000322)
0.3 2.7 GO:0097452 GAIT complex(GO:0097452)
0.3 1.6 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.3 5.8 GO:0000813 ESCRT I complex(GO:0000813)
0.3 0.8 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.3 5.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 1.8 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.2 3.4 GO:0005577 fibrinogen complex(GO:0005577)
0.2 1.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 9.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 7.8 GO:0031143 pseudopodium(GO:0031143)
0.2 0.7 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.2 1.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 1.3 GO:0031673 H zone(GO:0031673)
0.2 1.8 GO:0016013 syntrophin complex(GO:0016013)
0.2 2.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 2.1 GO:0000439 core TFIIH complex(GO:0000439)
0.2 4.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 3.2 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.2 1.3 GO:0032437 cuticular plate(GO:0032437)
0.2 0.6 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 2.6 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.9 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 1.3 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 0.4 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.4 GO:0031085 BLOC-3 complex(GO:0031085)
0.1 1.9 GO:0045180 basal cortex(GO:0045180)
0.1 6.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.8 GO:0005915 zonula adherens(GO:0005915)
0.1 1.1 GO:0034464 BBSome(GO:0034464)
0.1 0.3 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.8 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 5.4 GO:0001533 cornified envelope(GO:0001533)
0.1 1.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.6 GO:0090576 transcription factor TFIIIC complex(GO:0000127) RNA polymerase III transcription factor complex(GO:0090576)
0.1 1.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.5 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.1 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 1.0 GO:0070187 telosome(GO:0070187)
0.1 2.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.7 GO:0036020 endolysosome membrane(GO:0036020)
0.1 5.6 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 2.0 GO:0071437 invadopodium(GO:0071437)
0.1 1.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.0 1.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 6.7 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 3.0 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 3.2 GO:0014704 intercalated disc(GO:0014704)
0.0 6.4 GO:0016605 PML body(GO:0016605)
0.0 1.4 GO:0005921 gap junction(GO:0005921)
0.0 3.5 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 4.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.0 1.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 3.7 GO:0001650 fibrillar center(GO:0001650)
0.0 1.0 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.3 GO:0090543 Flemming body(GO:0090543)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0043034 costamere(GO:0043034)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 4.7 GO:0030027 lamellipodium(GO:0030027)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0000346 transcription export complex(GO:0000346)
0.0 0.8 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.3 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.9 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 7.1 GO:0000785 chromatin(GO:0000785)
0.0 1.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.9 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 2.0 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0016234 inclusion body(GO:0016234)
0.0 3.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.0 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 6.6 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.9 2.7 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.9 7.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.8 4.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.8 3.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.7 2.9 GO:0032427 GBD domain binding(GO:0032427)
0.7 4.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.5 3.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.4 6.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.4 1.6 GO:0070012 oligopeptidase activity(GO:0070012)
0.4 1.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.3 1.0 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.3 1.2 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.3 8.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.3 1.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.3 2.2 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 3.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 0.8 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.3 0.8 GO:0015235 cobalamin transporter activity(GO:0015235)
0.2 1.5 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.2 2.0 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.2 2.9 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 0.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.2 0.6 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.2 0.6 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.2 4.8 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2 1.1 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 0.9 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.2 2.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.2 0.8 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.2 0.7 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.2 1.0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.2 3.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 0.9 GO:0045174 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.2 1.4 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.2 0.5 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 1.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 1.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.4 GO:0048156 tau protein binding(GO:0048156)
0.1 0.9 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 0.4 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 3.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 4.1 GO:0031489 myosin V binding(GO:0031489)
0.1 0.4 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.1 3.8 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.7 GO:0050436 microfibril binding(GO:0050436)
0.1 0.3 GO:0090541 MIT domain binding(GO:0090541)
0.1 0.3 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.1 2.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.3 GO:0042731 PH domain binding(GO:0042731)
0.1 1.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.5 GO:0097677 STAT family protein binding(GO:0097677)
0.1 2.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.1 2.8 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 2.6 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.1 1.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 2.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.8 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 5.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 0.7 GO:0035473 lipase binding(GO:0035473)
0.1 0.8 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.9 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 1.8 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.7 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 3.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 2.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 3.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 0.4 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.6 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 1.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 2.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.1 0.7 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 2.7 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.5 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.7 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 1.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 2.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.9 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.7 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.4 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1 3.1 GO:0005109 frizzled binding(GO:0005109)
0.1 1.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.8 GO:0038132 neuregulin binding(GO:0038132)
0.1 6.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 0.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 1.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 3.4 GO:0016504 peptidase activator activity(GO:0016504)
0.0 1.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.3 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 2.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.3 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.9 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 1.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 4.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 7.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 2.3 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.0 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.7 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.0 GO:0017129 triglyceride binding(GO:0017129)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 2.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 1.2 GO:0032452 histone demethylase activity(GO:0032452)
0.0 1.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.8 GO:0017022 myosin binding(GO:0017022)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.8 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.8 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.0 1.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.0 2.7 GO:0005518 collagen binding(GO:0005518)
0.0 6.4 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 1.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 1.9 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.1 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.6 GO:0043022 ribosome binding(GO:0043022)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.8 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 5.4 GO:0003924 GTPase activity(GO:0003924)
0.0 2.2 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.3 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.0 GO:0004040 amidase activity(GO:0004040)
0.0 0.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 2.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.0 8.9 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.3 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.3 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 9.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 1.4 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 6.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.7 PID IL5 PATHWAY IL5-mediated signaling events
0.1 5.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.4 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 3.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 7.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 5.8 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 7.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 6.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.6 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.3 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 2.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 3.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.7 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 3.3 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.8 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 2.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 2.1 PID P73PATHWAY p73 transcription factor network
0.0 6.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.2 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.2 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.9 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.3 6.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3 8.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 7.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 5.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 6.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 7.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.4 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 4.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 5.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.6 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 7.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 2.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 3.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 2.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.9 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 3.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.6 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.8 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 2.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.5 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 1.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 2.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 9.8 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 2.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.8 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 1.7 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors