ISMARA results: CTCF

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CTCF_CTCFL

Z-value: 3.78

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Transcription factors associated with CTCF_CTCFL

Gene Symbol	Gene ID	Gene Info
CTCF Ensembl NCBI GeneCards UniProt	ENSG00000102974.10	CCCTC-binding factor
CTCFL Ensembl NCBI GeneCards UniProt	ENSG00000124092.8	CCCTC-binding factor like

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CTCFL	hg19_v2_chr20_-_56100179_56100265	0.16	5.1e-01	Click!
CTCF	hg19_v2_chr16_+_67596310_67596353	0.10	6.8e-01	Click!

Activity profile of CTCF_CTCFL motif

Sorted Z-values of CTCF_CTCFL motif

No targets for CTCF_CTCFL

Network of associatons between targets according to the STRING database.

First level regulatory network of CTCF_CTCFL

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	30.8	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.7	23.3	GO:0016185	synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.2	20.4	GO:0006958	complement activation, classical pathway(GO:0006958)
3.1	18.5	GO:1903412	response to bile acid(GO:1903412)
0.5	17.5	GO:0036109	alpha-linolenic acid metabolic process(GO:0036109) linoleic acid metabolic process(GO:0043651)
1.1	13.3	GO:0032286	central nervous system myelin maintenance(GO:0032286)
1.1	12.0	GO:0030259	lipid glycosylation(GO:0030259)
0.2	11.4	GO:0090140	regulation of mitochondrial fission(GO:0090140)
0.1	11.1	GO:0042733	embryonic digit morphogenesis(GO:0042733)
0.1	10.7	GO:0051384	response to glucocorticoid(GO:0051384)

Showing 1 to 10 of 357 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	56.8	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
2.1	23.0	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.3	21.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.1	17.1	GO:0072562	blood microparticle(GO:0072562)
4.0	15.8	GO:0097232	lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
1.2	12.0	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.5	11.2	GO:0036038	MKS complex(GO:0036038)
0.1	11.0	GO:0005758	mitochondrial intermembrane space(GO:0005758)
1.0	10.5	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	10.5	GO:0030133	transport vesicle(GO:0030133)

Showing 1 to 10 of 162 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	28.8	GO:0042974	retinoic acid receptor binding(GO:0042974)
0.1	25.5	GO:0008017	microtubule binding(GO:0008017)
1.5	18.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	14.0	GO:0005518	collagen binding(GO:0005518)
0.0	13.8	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3	13.6	GO:0000217	DNA secondary structure binding(GO:0000217)
0.1	12.9	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	12.2	GO:0042626	ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
2.4	12.0	GO:0003947	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.4	12.0	GO:0005095	GTPase inhibitor activity(GO:0005095)

Showing 1 to 10 of 257 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	22.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	21.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.2	18.5	PID FGF PATHWAY	FGF signaling pathway
0.2	17.1	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	16.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	11.9	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.3	9.8	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	9.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	9.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	9.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 10 of 56 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	24.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.7	19.5	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
1.1	18.5	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.6	17.5	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.3	15.3	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.2	14.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	12.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	12.0	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	9.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	9.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)

Showing 1 to 10 of 83 entries

Results for CTCF_CTCFL

Z-value: 3.78

Motif logo

Transcription factors associated with CTCF_CTCFL

Activity-expression correlation:

Activity profile of CTCF_CTCFL motif

Sorted Z-values of CTCF_CTCFL motif

No targets for CTCF_CTCFL

Network of associatons between targets according to the STRING database.

First level regulatory network of CTCF_CTCFL

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: