ISMARA results: DLX1_HOXA3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DLX1_HOXA3_BARX2

Z-value: 0.89

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Transcription factors associated with DLX1_HOXA3_BARX2

Gene Symbol	Gene ID	Gene Info
DLX1 Ensembl NCBI GeneCards UniProt	ENSG00000144355.10	distal-less homeobox 1
HOXA3 Ensembl NCBI GeneCards UniProt	ENSG00000105997.18	homeobox A3
BARX2 Ensembl NCBI GeneCards UniProt	ENSG00000043039.5	BARX homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BARX2	hg19_v2_chr11_+_129245796_129245835	-0.89	1.1e-07	Click!
HOXA3	hg19_v2_chr7_-_27179814_27179840	0.88	3.2e-07	Click!
DLX1	hg19_v2_chr2_+_172950227_172950264	0.68	1.0e-03	Click!

Activity profile of DLX1_HOXA3_BARX2 motif

Sorted Z-values of DLX1_HOXA3_BARX2 motif

No targets for DLX1_HOXA3_BARX2

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX1_HOXA3_BARX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	5.9	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1	4.2	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.1	3.7	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.7	3.5	GO:0072709	cellular response to sorbitol(GO:0072709)
0.0	3.5	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	3.5	GO:0051225	spindle assembly(GO:0051225)
0.7	2.9	GO:2000863	positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0	2.5	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8	2.4	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.1	2.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)

Showing 1 to 10 of 205 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	3.8	GO:0042627	chylomicron(GO:0042627)
0.2	3.4	GO:0070652	HAUS complex(GO:0070652)
0.0	3.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	3.0	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	2.8	GO:0072562	blood microparticle(GO:0072562)
0.0	2.5	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.2	2.4	GO:0072687	meiotic spindle(GO:0072687)
0.0	2.2	GO:0045095	keratin filament(GO:0045095)
0.0	2.1	GO:0000792	heterochromatin(GO:0000792)

Showing 1 to 10 of 70 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.9	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.1	4.0	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	3.2	GO:0050840	extracellular matrix binding(GO:0050840)
0.2	3.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	2.7	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	2.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.4	2.0	GO:0019770	IgG receptor activity(GO:0019770)
0.4	2.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.2	1.8	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2	1.8	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.7	PID IFNG PATHWAY	IFN-gamma pathway
0.0	1.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	1.3	PID ATM PATHWAY	ATM pathway
0.0	1.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.9	PID BMP PATHWAY	BMP receptor signaling
0.0	0.7	ST GA12 PATHWAY	G alpha 12 Pathway

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.7	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	3.5	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	3.4	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	3.4	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0	3.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	2.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	2.0	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.9	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	1.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	1.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism

Showing 1 to 10 of 43 entries

Results for DLX1_HOXA3_BARX2

Z-value: 0.89

Motif logo

Transcription factors associated with DLX1_HOXA3_BARX2

Activity-expression correlation:

Activity profile of DLX1_HOXA3_BARX2 motif

Sorted Z-values of DLX1_HOXA3_BARX2 motif

No targets for DLX1_HOXA3_BARX2

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX1_HOXA3_BARX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: