ISMARA results: DLX3_EVX1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DLX3_EVX1_MEOX1

Z-value: 0.67

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Transcription factors associated with DLX3_EVX1_MEOX1

Gene Symbol	Gene ID	Gene Info
DLX3 Ensembl NCBI GeneCards UniProt	ENSG00000064195.7	distal-less homeobox 3
EVX1 Ensembl NCBI GeneCards UniProt	ENSG00000106038.8	even-skipped homeobox 1
MEOX1 Ensembl NCBI GeneCards UniProt	ENSG00000005102.8	mesenchyme homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
DLX3	hg19_v2_chr17_-_48072574_48072597	-0.69	7.5e-04	Click!
MEOX1	hg19_v2_chr17_-_41739283_41739322	-0.32	1.7e-01	Click!
EVX1	hg19_v2_chr7_+_27282319_27282394	0.17	4.8e-01	Click!

Activity profile of DLX3_EVX1_MEOX1 motif

Sorted Z-values of DLX3_EVX1_MEOX1 motif

No targets for DLX3_EVX1_MEOX1

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1	1.8	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.2	1.7	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.4	1.5	GO:0002426	immunoglobulin production in mucosal tissue(GO:0002426)
0.0	1.2	GO:0006625	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1	1.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.1	1.0	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.1	1.0	GO:0021842	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0	1.0	GO:0048240	sperm capacitation(GO:0048240)
0.0	1.0	GO:0006099	tricarboxylic acid cycle(GO:0006099)

Showing 1 to 10 of 81 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.7	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1	1.6	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	1.1	GO:0032420	stereocilium(GO:0032420)
0.1	1.0	GO:0097524	sperm plasma membrane(GO:0097524)
0.1	0.9	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.9	GO:0030673	axolemma(GO:0030673)
0.2	0.7	GO:0042720	mitochondrial inner membrane peptidase complex(GO:0042720)
0.2	0.7	GO:0005873	plus-end kinesin complex(GO:0005873)
0.0	0.7	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	0.6	GO:0031302	intrinsic component of endosome membrane(GO:0031302)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:0000150	recombinase activity(GO:0000150)
0.1	1.6	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.5	1.5	GO:0047225	acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.0	1.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.2	1.1	GO:0008665	2'-phosphotransferase activity(GO:0008665)
0.3	1.0	GO:0036440	citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.1	1.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	1.0	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	1.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	1.0	GO:0031489	myosin V binding(GO:0031489)

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
1.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
1.6	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
1.0	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
1.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
1.0	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.7	REACTOME KINESINS	Genes involved in Kinesins
0.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.3	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions

Showing 1 to 10 of 15 entries

Results for DLX3_EVX1_MEOX1

Z-value: 0.67

Motif logo

Transcription factors associated with DLX3_EVX1_MEOX1

Activity-expression correlation:

Activity profile of DLX3_EVX1_MEOX1 motif

Sorted Z-values of DLX3_EVX1_MEOX1 motif

No targets for DLX3_EVX1_MEOX1

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX3_EVX1_MEOX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: