ISMARA results: DMC1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMC1

Z-value: 0.89

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Transcription factors associated with DMC1

Gene Symbol	Gene ID	Gene Info
DMC1 Ensembl NCBI GeneCards UniProt	ENSG00000100206.5	DNA meiotic recombinase 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
DMC1	hg19_v2_chr22_-_38966123_38966163	-0.69	7.5e-04	Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

No targets for DMC1

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.2	3.2	GO:0015884	folic acid transport(GO:0015884)
0.1	3.2	GO:0090026	positive regulation of monocyte chemotaxis(GO:0090026)
0.1	2.0	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2	1.4	GO:0097398	response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.2	1.0	GO:0046110	xanthine metabolic process(GO:0046110)
0.1	0.8	GO:0072658	maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1	0.8	GO:1902963	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0	0.8	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.6	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)

Showing 1 to 10 of 25 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	3.0	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	0.8	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.0	0.8	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.6	GO:0005753	mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0	0.5	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1	0.3	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.2	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.0	0.2	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)

Showing 1 to 10 of 10 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.2	GO:0005542	folic acid binding(GO:0005542)
0.0	3.0	GO:0003785	actin monomer binding(GO:0003785)
0.1	2.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1	1.4	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.1	1.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.1	0.8	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.8	GO:0030507	spectrin binding(GO:0030507)
0.0	0.8	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.6	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)

Showing 1 to 10 of 19 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
2.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
1.0	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.6	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.5	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.4	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.4	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors

Showing 1 to 8 of 8 entries

Results for DMC1

Z-value: 0.89

Motif logo

Transcription factors associated with DMC1

Activity-expression correlation:

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

No targets for DMC1

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: