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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for DUXA
Z-value: 1.59
Motif logo
Transcription factors associated with DUXA
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
DUXA
|
ENSG00000258873.2 | double homeobox A |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DUXA | hg19_v2_chr19_-_57678811_57678811 | -0.71 | 4.7e-04 | Click! |
Activity profile of DUXA motif
Sorted Z-values of DUXA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of DUXA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.7 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 1.1 | 5.4 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.7 | 2.0 | GO:0006433 | glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433) |
| 0.6 | 2.5 | GO:2001162 | regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162) |
| 0.5 | 1.6 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.4 | 2.1 | GO:0046086 | adenosine biosynthetic process(GO:0046086) |
| 0.4 | 1.9 | GO:0046504 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.4 | 8.2 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.3 | 1.3 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.3 | 2.2 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.3 | 1.7 | GO:0018032 | protein amidation(GO:0018032) |
| 0.3 | 1.9 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.3 | 3.0 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.3 | 0.8 | GO:1902955 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.2 | 1.2 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.2 | 0.7 | GO:0051714 | negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714) |
| 0.2 | 1.1 | GO:0043553 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.2 | 1.0 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.2 | 2.7 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.2 | 2.8 | GO:0060613 | fat pad development(GO:0060613) |
| 0.2 | 1.2 | GO:1904381 | Golgi apparatus mannose trimming(GO:1904381) |
| 0.2 | 0.7 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.2 | 0.8 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.2 | 1.1 | GO:0010710 | regulation of collagen catabolic process(GO:0010710) |
| 0.2 | 2.1 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.2 | 0.5 | GO:0048007 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.2 | 0.8 | GO:0043335 | protein unfolding(GO:0043335) |
| 0.2 | 0.8 | GO:0034334 | adherens junction maintenance(GO:0034334) |
| 0.2 | 1.7 | GO:0090032 | negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032) |
| 0.2 | 2.0 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.1 | 0.9 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 2.7 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 0.8 | GO:0035633 | maintenance of blood-brain barrier(GO:0035633) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 1.1 | GO:1905232 | cellular response to L-glutamate(GO:1905232) |
| 0.1 | 2.0 | GO:2000628 | production of siRNA involved in RNA interference(GO:0030422) regulation of miRNA metabolic process(GO:2000628) |
| 0.1 | 10.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 1.9 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 2.3 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 1.4 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 0.6 | GO:0061015 | snRNA import into nucleus(GO:0061015) |
| 0.1 | 0.5 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.1 | 1.4 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 0.6 | GO:2000521 | negative regulation of immunological synapse formation(GO:2000521) |
| 0.1 | 4.1 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.1 | 0.5 | GO:0043686 | co-translational protein modification(GO:0043686) |
| 0.1 | 0.7 | GO:0032377 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.1 | 0.3 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.1 | 1.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.4 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.1 | 0.5 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 1.5 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 0.3 | GO:0070638 | nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638) |
| 0.1 | 1.2 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 1.8 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
| 0.1 | 0.6 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.1 | 1.2 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.1 | 0.9 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 0.4 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.1 | 1.1 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 1.9 | GO:0009950 | dorsal/ventral axis specification(GO:0009950) |
| 0.1 | 0.7 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 1.1 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.1 | 0.3 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.1 | 0.2 | GO:0002101 | tRNA wobble cytosine modification(GO:0002101) |
| 0.1 | 0.3 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.1 | 1.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.1 | 0.8 | GO:0002643 | regulation of tolerance induction(GO:0002643) |
| 0.1 | 0.7 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 1.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.4 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.0 | 0.9 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 0.9 | GO:0060453 | regulation of gastric acid secretion(GO:0060453) |
| 0.0 | 0.2 | GO:0043605 | cellular amide catabolic process(GO:0043605) |
| 0.0 | 0.3 | GO:0072602 | interleukin-33-mediated signaling pathway(GO:0038172) interleukin-4 secretion(GO:0072602) |
| 0.0 | 1.7 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.9 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 0.9 | GO:0036148 | phosphatidylglycerol acyl-chain remodeling(GO:0036148) |
| 0.0 | 0.2 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.0 | 0.7 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.3 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.0 | 4.2 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.5 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.0 | 1.7 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 0.4 | GO:0032808 | lacrimal gland development(GO:0032808) |
| 0.0 | 1.8 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 0.6 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.8 | GO:0051531 | NFAT protein import into nucleus(GO:0051531) |
| 0.0 | 0.1 | GO:0044210 | 'de novo' CTP biosynthetic process(GO:0044210) |
| 0.0 | 1.4 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 0.2 | GO:0060686 | negative regulation of prostatic bud formation(GO:0060686) |
| 0.0 | 0.7 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.0 | 1.4 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.0 | 0.4 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.0 | 1.5 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.8 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 3.0 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.0 | 0.1 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 0.0 | 0.8 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.0 | 0.1 | GO:0036378 | calcitriol biosynthetic process from calciol(GO:0036378) |
| 0.0 | 0.4 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.1 | GO:0021816 | lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816) |
| 0.0 | 0.1 | GO:1902856 | negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 0.0 | 0.3 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.0 | 0.2 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) |
| 0.0 | 0.1 | GO:1904749 | regulation of protein localization to nucleolus(GO:1904749) |
| 0.0 | 0.7 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.0 | 0.6 | GO:0044030 | regulation of DNA methylation(GO:0044030) |
| 0.0 | 2.1 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.0 | 0.2 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.0 | 0.1 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.0 | 0.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.7 | GO:0009880 | embryonic pattern specification(GO:0009880) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.0 | 0.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.0 | 1.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.3 | GO:0098719 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 1.1 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.0 | 0.1 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.0 | 0.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.1 | GO:0016246 | RNA interference(GO:0016246) |
| 0.0 | 0.3 | GO:0007635 | chemosensory behavior(GO:0007635) |
| 0.0 | 0.4 | GO:0050962 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
| 0.0 | 0.1 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.0 | 3.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 0.1 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.4 | 1.1 | GO:0034677 | integrin alpha7-beta1 complex(GO:0034677) |
| 0.4 | 1.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.2 | 2.0 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.2 | 2.5 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.2 | 1.6 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.2 | 2.4 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.2 | 0.6 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 2.1 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.1 | 0.4 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.1 | 8.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.5 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.1 | 0.8 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.1 | 0.5 | GO:0031417 | NatC complex(GO:0031417) |
| 0.1 | 2.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 1.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 0.5 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 0.7 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.4 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
| 0.1 | 1.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 0.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.7 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 1.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.7 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 1.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 1.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.7 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.0 | 1.5 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 1.6 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.0 | 2.7 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.7 | GO:0046540 | U4/U6 x U5 tri-snRNP complex(GO:0046540) |
| 0.0 | 0.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 2.1 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.6 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 2.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 3.2 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.5 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 5.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.6 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 3.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.5 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 0.5 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.1 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 0.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.3 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.4 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.0 | 0.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 2.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.9 | GO:1990904 | intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904) |
| 0.0 | 0.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 1.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.4 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 2.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.6 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 1.1 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 2.2 | GO:0045177 | apical part of cell(GO:0045177) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0004827 | glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827) |
| 0.3 | 2.0 | GO:0032296 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.3 | 1.9 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.3 | 1.6 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
| 0.3 | 2.1 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.3 | 1.5 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.3 | 1.7 | GO:0004598 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.3 | 1.4 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.2 | 3.5 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.2 | 3.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 0.7 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.2 | 0.6 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.2 | 1.0 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.2 | 1.2 | GO:0070728 | leucine binding(GO:0070728) |
| 0.2 | 1.6 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.2 | 0.7 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.2 | 0.7 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.2 | 1.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 1.1 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.1 | 2.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.6 | GO:0019863 | IgE binding(GO:0019863) |
| 0.1 | 1.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 2.3 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 0.3 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.1 | 1.7 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.1 | 0.3 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.1 | 1.2 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 2.1 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.1 | 3.5 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.9 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.1 | 1.1 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064) |
| 0.1 | 3.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 1.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.3 | GO:0004556 | alpha-amylase activity(GO:0004556) |
| 0.1 | 0.3 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.1 | 0.8 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 2.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 0.8 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 0.9 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.1 | 0.7 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 1.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 0.3 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 0.5 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 0.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.3 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.0 | 0.2 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.0 | 0.8 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 1.5 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 5.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 1.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 7.3 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 1.7 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 10.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 2.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.8 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.2 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.0 | 1.1 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.3 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.0 | 1.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.1 | GO:0070643 | vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643) |
| 0.0 | 0.1 | GO:0003883 | CTP synthase activity(GO:0003883) |
| 0.0 | 0.6 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.5 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.4 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 3.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.1 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.0 | 0.5 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.8 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.0 | 0.5 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 1.1 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.3 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 0.1 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 0.0 | 0.9 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 4.4 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.0 | 0.6 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.1 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 2.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.4 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.0 | 0.4 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 0.2 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.9 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.3 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.8 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 0.1 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.0 | 0.1 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 0.4 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.2 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.5 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.1 | GO:0032051 | clathrin light chain binding(GO:0032051) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 4.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 5.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 4.9 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.5 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.7 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 4.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 6.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.7 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.3 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.6 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 0.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 0.4 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 0.4 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 2.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.9 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 3.8 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.7 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 2.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 3.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.6 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 2.0 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 3.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 0.9 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 1.1 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 2.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.6 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 1.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.1 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 2.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 2.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.2 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.1 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.0 | 0.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.9 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.5 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.3 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.9 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.2 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.0 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 0.4 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.7 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 1.3 | REACTOME REGULATION OF APOPTOSIS | Genes involved in Regulation of Apoptosis |
| 0.0 | 0.2 | REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 1.1 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.7 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |