ISMARA results: E2F3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F3

Z-value: 4.29

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Transcription factors associated with E2F3

Gene Symbol	Gene ID	Gene Info
E2F3 Ensembl NCBI GeneCards UniProt	ENSG00000112242.10	E2F transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F3	hg19_v2_chr6_+_20403997_20404034	0.84	3.1e-06	Click!

Activity profile of E2F3 motif

Sorted Z-values of E2F3 motif

No targets for E2F3

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	21.9	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.1	13.1	GO:0007062	sister chromatid cohesion(GO:0007062)
0.1	11.7	GO:0007077	mitotic nuclear envelope disassembly(GO:0007077)
0.3	11.5	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.6	8.9	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.9	8.2	GO:0006021	inositol biosynthetic process(GO:0006021)
0.2	8.2	GO:0007099	centriole replication(GO:0007099)
0.1	7.9	GO:0051225	spindle assembly(GO:0051225)
0.1	7.9	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.9	7.4	GO:0090166	Golgi disassembly(GO:0090166)

Showing 1 to 10 of 714 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	23.0	GO:1902711	GABA-A receptor complex(GO:1902711)
0.1	20.0	GO:0000776	kinetochore(GO:0000776)
0.1	11.9	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	10.7	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	8.4	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.0	8.3	GO:0032587	ruffle membrane(GO:0032587)
1.1	7.8	GO:0031262	Ndc80 complex(GO:0031262)
0.1	7.8	GO:0097542	ciliary tip(GO:0097542)
0.4	7.5	GO:0042555	MCM complex(GO:0042555)
0.6	7.4	GO:0042788	polysomal ribosome(GO:0042788)

Showing 1 to 10 of 295 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	23.0	GO:0004890	GABA-A receptor activity(GO:0004890)
0.2	12.8	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.3	12.4	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
2.3	9.0	GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.2	8.6	GO:0000217	DNA secondary structure binding(GO:0000217)
0.2	8.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.9	8.1	GO:0004883	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0	8.1	GO:0017048	Rho GTPase binding(GO:0017048)
0.9	8.0	GO:0052833	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.6	8.0	GO:0032027	myosin light chain binding(GO:0032027)

Showing 1 to 10 of 496 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.2	PID AURORA B PATHWAY	Aurora B signaling
0.1	18.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.2	14.8	PID PLK1 PATHWAY	PLK1 signaling events
0.2	14.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	13.6	PID FANCONI PATHWAY	Fanconi anemia pathway
0.7	10.4	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	9.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	8.3	PID E2F PATHWAY	E2F transcription factor network
0.1	7.6	ST GA13 PATHWAY	G alpha 13 Pathway
0.3	6.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 10 of 77 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	48.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.8	23.3	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	19.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	11.9	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.6	10.0	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	10.0	REACTOME REGULATION OF MITOTIC CELL CYCLE	Genes involved in Regulation of mitotic cell cycle
0.3	9.2	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.3	9.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.5	8.7	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1	8.0	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity

Showing 1 to 10 of 153 entries

Results for E2F3

Z-value: 4.29

Motif logo

Transcription factors associated with E2F3

Activity-expression correlation:

Activity profile of E2F3 motif

Sorted Z-values of E2F3 motif

No targets for E2F3

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: