ISMARA results: E2F4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F4

Z-value: 3.51

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Transcription factors associated with E2F4

Gene Symbol	Gene ID	Gene Info
E2F4 Ensembl NCBI GeneCards UniProt	ENSG00000205250.4	E2F transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F4	hg19_v2_chr16_+_67226019_67226127	0.62	3.5e-03	Click!

Activity profile of E2F4 motif

Sorted Z-values of E2F4 motif

No targets for E2F4

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	9.4	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
1.3	9.3	GO:0044806	G-quadruplex DNA unwinding(GO:0044806)
0.8	9.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
1.1	9.0	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1	7.6	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
2.5	7.5	GO:0070510	regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.5	7.3	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1	6.3	GO:0036297	interstrand cross-link repair(GO:0036297)
0.0	6.3	GO:0051225	spindle assembly(GO:0051225)
1.6	6.2	GO:1904117	response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)

Showing 1 to 10 of 187 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.7	GO:0042575	DNA polymerase complex(GO:0042575)
0.1	9.6	GO:0043198	dendritic shaft(GO:0043198)
0.5	9.4	GO:0042555	MCM complex(GO:0042555)
0.4	8.7	GO:0000800	lateral element(GO:0000800)
0.7	8.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.9	8.1	GO:0005663	DNA replication factor C complex(GO:0005663)
1.9	7.5	GO:0031436	BRCA1-BARD1 complex(GO:0031436)
0.2	6.8	GO:0051233	spindle midzone(GO:0051233)
0.1	6.6	GO:0005871	kinesin complex(GO:0005871)
0.1	5.7	GO:0044815	DNA packaging complex(GO:0044815)

Showing 1 to 10 of 104 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.1	GO:0003684	damaged DNA binding(GO:0003684)
0.2	10.2	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
1.0	9.6	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	9.4	GO:0046982	protein heterodimerization activity(GO:0046982)
0.3	7.3	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1	7.0	GO:0003777	microtubule motor activity(GO:0003777)
0.7	6.3	GO:0000405	bubble DNA binding(GO:0000405)
0.3	6.0	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.4	5.7	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.8	5.4	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)

Showing 1 to 10 of 142 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	36.1	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	14.2	PID ATR PATHWAY	ATR signaling pathway
0.2	7.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	6.8	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	5.3	PID AURORA A PATHWAY	Aurora A signaling
0.1	5.0	PID PLK1 PATHWAY	PLK1 signaling events
0.0	4.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	3.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	3.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	3.2	PID IL4 2PATHWAY	IL4-mediated signaling events

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	19.8	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.7	13.6	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.1	13.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	13.0	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.6	11.8	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	8.7	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.7	8.5	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.2	8.5	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.3	7.3	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.3	7.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1

Showing 1 to 10 of 53 entries

Results for E2F4

Z-value: 3.51

Motif logo

Transcription factors associated with E2F4

Activity-expression correlation:

Activity profile of E2F4 motif

Sorted Z-values of E2F4 motif

No targets for E2F4

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: