ISMARA results: E2F6

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F6

Z-value: 3.70

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Transcription factors associated with E2F6

Gene Symbol	Gene ID	Gene Info
E2F6 Ensembl NCBI GeneCards UniProt	ENSG00000169016.12	E2F transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F6	hg19_v2_chr2_-_11606275_11606289	-0.89	1.7e-07	Click!

Activity profile of E2F6 motif

Sorted Z-values of E2F6 motif

No targets for E2F6

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.3	GO:0043484	regulation of RNA splicing(GO:0043484)
0.1	24.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.6	19.2	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
0.5	16.3	GO:0031581	hemidesmosome assembly(GO:0031581)
1.2	13.3	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
1.6	13.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
1.2	11.9	GO:1901315	negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.8	11.1	GO:1901166	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
2.1	10.3	GO:0021623	optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.5	10.0	GO:0050812	regulation of acyl-CoA biosynthetic process(GO:0050812)

Showing 1 to 10 of 752 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	39.0	GO:0016607	nuclear speck(GO:0016607)
0.1	38.4	GO:0005911	cell-cell junction(GO:0005911)
0.1	26.4	GO:0016604	nuclear body(GO:0016604)
1.6	19.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	18.0	GO:0005905	clathrin-coated pit(GO:0005905)
0.1	17.6	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	17.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.4	16.9	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.4	16.1	GO:0030057	desmosome(GO:0030057)
0.1	14.5	GO:0030027	lamellipodium(GO:0030027)

Showing 1 to 10 of 274 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	36.1	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1	26.2	GO:0045296	cadherin binding(GO:0045296)
1.0	22.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2	21.1	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.8	18.9	GO:0045499	chemorepellent activity(GO:0045499)
0.3	17.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.4	15.1	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2	12.7	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.5	12.3	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1	12.3	GO:0017124	SH3 domain binding(GO:0017124)

Showing 1 to 10 of 452 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.2	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.3	22.7	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.3	20.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	15.7	PID RHOA PATHWAY	RhoA signaling pathway
0.6	15.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	14.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	13.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.2	12.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	11.6	PID MYC PATHWAY	C-MYC pathway
0.1	10.8	PID P73PATHWAY	p73 transcription factor network

Showing 1 to 10 of 89 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	22.9	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	19.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.2	18.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.5	14.0	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	13.6	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.3	12.2	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.2	11.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	11.7	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	10.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2	10.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants

Showing 1 to 10 of 142 entries

Results for E2F6

Z-value: 3.70

Motif logo

Transcription factors associated with E2F6

Activity-expression correlation:

Activity profile of E2F6 motif

Sorted Z-values of E2F6 motif

No targets for E2F6

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: