ISMARA results: E2F7

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F7_E2F1

Z-value: 8.68

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Transcription factors associated with E2F7_E2F1

Gene Symbol	Gene ID	Gene Info
E2F7 Ensembl NCBI GeneCards UniProt	ENSG00000165891.11	E2F transcription factor 7
E2F1 Ensembl NCBI GeneCards UniProt	ENSG00000101412.9	E2F transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F1	hg19_v2_chr20_-_32274179_32274213	0.82	1.2e-05	Click!
E2F7	hg19_v2_chr12_-_77459306_77459365	0.66	1.7e-03	Click!

Activity profile of E2F7_E2F1 motif

Sorted Z-values of E2F7_E2F1 motif

No targets for E2F7_E2F1

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F7_E2F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	49.4	GO:0051225	spindle assembly(GO:0051225)
1.2	48.3	GO:0031055	chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
3.6	47.3	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
1.1	46.6	GO:0006270	DNA replication initiation(GO:0006270)
0.6	42.2	GO:0036297	interstrand cross-link repair(GO:0036297)
4.9	38.9	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
7.1	35.5	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
1.0	32.6	GO:0000732	strand displacement(GO:0000732)
0.9	27.5	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
2.2	25.9	GO:0010032	meiotic chromosome condensation(GO:0010032)

Showing 1 to 10 of 651 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	65.4	GO:0042555	MCM complex(GO:0042555)
0.4	44.1	GO:0000777	condensed chromosome kinetochore(GO:0000777)
4.7	41.9	GO:0005663	DNA replication factor C complex(GO:0005663)
3.1	39.7	GO:0000796	condensin complex(GO:0000796)
11.7	35.0	GO:0032302	MutSbeta complex(GO:0032302)
2.4	33.5	GO:0070652	HAUS complex(GO:0070652)
2.4	28.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.2	28.1	GO:0000781	chromosome, telomeric region(GO:0000781)
3.4	26.8	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
6.0	24.0	GO:0031436	BRCA1-BARD1 complex(GO:0031436)

Showing 1 to 10 of 273 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	58.0	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
4.0	40.1	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
11.7	35.0	GO:0032181	double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.4	33.2	GO:0003684	damaged DNA binding(GO:0003684)
0.2	30.9	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.2	30.9	GO:0042393	histone binding(GO:0042393)
1.3	26.9	GO:0003688	DNA replication origin binding(GO:0003688)
3.4	26.8	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.8	26.7	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.1	22.7	GO:0004386	helicase activity(GO:0004386)

Showing 1 to 10 of 400 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	139.6	PID FANCONI PATHWAY	Fanconi anemia pathway
1.1	54.3	PID ATR PATHWAY	ATR signaling pathway
0.3	37.0	PID E2F PATHWAY	E2F transcription factor network
0.4	35.4	PID AURORA B PATHWAY	Aurora B signaling
0.2	22.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.3	17.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	16.8	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	14.3	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	13.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
1.1	13.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 67 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.8	76.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
3.6	68.2	REACTOME POL SWITCHING	Genes involved in Polymerase switching
1.6	56.6	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
1.8	51.5	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.7	51.4	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.4	42.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.5	40.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
1.0	36.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.5	24.2	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.6	22.0	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates

Showing 1 to 10 of 132 entries

Results for E2F7_E2F1

Z-value: 8.68

Motif logo

Transcription factors associated with E2F7_E2F1

Activity-expression correlation:

Activity profile of E2F7_E2F1 motif

Sorted Z-values of E2F7_E2F1 motif

No targets for E2F7_E2F1

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F7_E2F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: