ISMARA results: E2F8

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F8

Z-value: 2.33

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Transcription factors associated with E2F8

Gene Symbol	Gene ID	Gene Info
E2F8 Ensembl NCBI GeneCards UniProt	ENSG00000129173.8	E2F transcription factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F8	hg19_v2_chr11_-_19262486_19262512	0.78	6.0e-05	Click!

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

No targets for E2F8

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	12.8	GO:0032060	bleb assembly(GO:0032060)
1.9	11.3	GO:0034421	post-translational protein acetylation(GO:0034421)
0.2	11.2	GO:0006270	DNA replication initiation(GO:0006270)
0.8	9.9	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.7	9.6	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.5	8.6	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.2	6.1	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
1.9	5.7	GO:0033364	mast cell secretory granule organization(GO:0033364)
0.1	5.3	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	5.2	GO:0008033	tRNA processing(GO:0008033)

Showing 1 to 10 of 149 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	18.4	GO:0042555	MCM complex(GO:0042555)
0.3	12.8	GO:0043218	compact myelin(GO:0043218)
0.2	9.7	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.4	8.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.2	5.7	GO:0042588	zymogen granule(GO:0042588)
0.0	5.6	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.4	5.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.7	5.2	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.9	5.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
1.2	4.7	GO:0031523	Myb complex(GO:0031523)

Showing 1 to 10 of 69 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	17.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	10.3	GO:0035064	methylated histone binding(GO:0035064)
0.2	8.8	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.1	7.0	GO:0017022	myosin binding(GO:0017022)
0.8	6.7	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.5	6.1	GO:0005019	platelet-derived growth factor beta-receptor activity(GO:0005019)
1.1	4.6	GO:0047860	diiodophenylpyruvate reductase activity(GO:0047860)
0.0	4.5	GO:0005518	collagen binding(GO:0005518)
0.9	4.3	GO:0044378	non-sequence-specific DNA binding, bending(GO:0044378)
1.0	4.1	GO:0003896	DNA primase activity(GO:0003896)

Showing 1 to 10 of 106 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	7.3	PID BARD1 PATHWAY	BARD1 signaling events
0.1	4.6	PID ATR PATHWAY	ATR signaling pathway
0.1	4.6	PID AURORA A PATHWAY	Aurora A signaling
0.0	4.4	PID E2F PATHWAY	E2F transcription factor network
0.0	2.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	2.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	1.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.7	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.5	PID BMP PATHWAY	BMP receptor signaling

Showing 1 to 10 of 15 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	21.0	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.4	8.0	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.2	6.0	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.2	5.5	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	4.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.3	4.5	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.2	4.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	3.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	3.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	3.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

Showing 1 to 10 of 39 entries

Results for E2F8

Z-value: 2.33

Motif logo

Transcription factors associated with E2F8

Activity-expression correlation:

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

No targets for E2F8

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: