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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F8

Z-value: 2.33

Motif logo

Transcription factors associated with E2F8

Gene Symbol Gene ID Gene Info
ENSG00000129173.8 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F8hg19_v2_chr11_-_19262486_192625120.786.0e-05Click!

Activity profile of E2F8 motif

Sorted Z-values of E2F8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.7 GO:0033364 mast cell secretory granule organization(GO:0033364)
1.9 11.3 GO:0034421 post-translational protein acetylation(GO:0034421)
1.1 3.2 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.0 3.0 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.8 9.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.7 9.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.7 2.1 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
0.7 4.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.7 0.7 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.7 2.0 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.6 1.9 GO:0071812 circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.6 4.4 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.5 2.1 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.5 8.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.5 2.9 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.5 1.4 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.5 1.4 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.4 2.2 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.4 12.8 GO:0032060 bleb assembly(GO:0032060)
0.4 1.8 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.4 1.1 GO:0035573 N-terminal peptidyl-alanine methylation(GO:0018011) N-terminal peptidyl-alanine trimethylation(GO:0018012) N-terminal peptidyl-glycine methylation(GO:0018013) N-terminal peptidyl-proline dimethylation(GO:0018016) peptidyl-alanine modification(GO:0018194) N-terminal peptidyl-proline methylation(GO:0035568) N-terminal peptidyl-serine methylation(GO:0035570) N-terminal peptidyl-serine dimethylation(GO:0035572) N-terminal peptidyl-serine trimethylation(GO:0035573)
0.3 1.4 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.3 1.3 GO:1903566 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.3 4.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.3 2.6 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.3 2.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 2.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.3 1.9 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.3 4.6 GO:0006108 malate metabolic process(GO:0006108)
0.3 0.8 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.3 0.8 GO:0006481 C-terminal protein methylation(GO:0006481)
0.3 1.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.3 2.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.3 3.7 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 1.2 GO:0021523 somatic motor neuron differentiation(GO:0021523)
0.2 11.2 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.9 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 2.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 1.9 GO:0046826 negative regulation of protein export from nucleus(GO:0046826) protein K6-linked ubiquitination(GO:0085020)
0.2 3.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 6.1 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.2 0.8 GO:1990637 response to prolactin(GO:1990637)
0.2 1.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 1.3 GO:0019075 virus maturation(GO:0019075)
0.2 3.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.2 3.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 1.0 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.2 1.0 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.2 0.5 GO:0060796 regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796)
0.2 1.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 3.5 GO:0000732 strand displacement(GO:0000732)
0.1 0.6 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 1.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 0.6 GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 0.7 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 0.8 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.1 1.0 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.5 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.1 2.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 5.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.1 1.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.0 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.7 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.0 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 1.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1 0.3 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.6 GO:0015811 L-cystine transport(GO:0015811)
0.1 0.9 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 0.6 GO:0070475 rRNA base methylation(GO:0070475) mRNA methylation(GO:0080009)
0.1 0.8 GO:0016139 glycoside catabolic process(GO:0016139)
0.1 2.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 0.3 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.1 0.4 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 2.6 GO:0071539 protein localization to centrosome(GO:0071539)
0.1 0.2 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.1 0.3 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 0.4 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 2.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.7 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.5 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 1.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 0.5 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 0.5 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 0.6 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.1 0.6 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.9 GO:0006265 DNA topological change(GO:0006265)
0.1 1.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.1 2.7 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.4 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.6 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.2 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.1 0.8 GO:0010155 regulation of proton transport(GO:0010155)
0.1 3.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.3 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.7 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 1.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.9 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 2.3 GO:0048536 spleen development(GO:0048536)
0.0 3.8 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 0.3 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.4 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.6 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.4 GO:0072718 response to cisplatin(GO:0072718)
0.0 1.6 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 2.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 5.2 GO:0008033 tRNA processing(GO:0008033)
0.0 1.7 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.6 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.8 GO:0009223 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 2.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 1.1 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 0.3 GO:1904970 brush border assembly(GO:1904970)
0.0 0.4 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 1.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.9 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.2 GO:2001023 regulation of response to drug(GO:2001023)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 1.0 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.1 GO:0070126 mitochondrial translational termination(GO:0070126)
0.0 1.0 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.8 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.2 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.0 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0 0.5 GO:0006284 base-excision repair(GO:0006284)
0.0 0.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.8 GO:0035329 hippo signaling(GO:0035329)
0.0 0.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 1.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.5 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0031523 Myb complex(GO:0031523)
1.1 4.4 GO:1990423 RZZ complex(GO:1990423)
1.1 3.2 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.9 18.4 GO:0042555 MCM complex(GO:0042555)
0.9 5.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.7 5.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.7 2.6 GO:0005873 plus-end kinesin complex(GO:0005873)
0.5 1.9 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.5 2.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 8.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.4 5.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 12.8 GO:0043218 compact myelin(GO:0043218)
0.3 1.9 GO:1990246 uniplex complex(GO:1990246)
0.3 2.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.3 1.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.3 0.6 GO:0033186 CAF-1 complex(GO:0033186)
0.3 1.7 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.3 3.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 5.7 GO:0042588 zymogen granule(GO:0042588)
0.2 0.7 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.2 9.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 1.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 1.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 2.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 2.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 2.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.2 3.0 GO:0032039 integrator complex(GO:0032039)
0.2 4.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 1.4 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 1.4 GO:0033503 HULC complex(GO:0033503)
0.1 0.8 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.8 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 2.0 GO:0071439 clathrin complex(GO:0071439)
0.1 1.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 2.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.3 GO:0035253 ciliary rootlet(GO:0035253)
0.1 0.9 GO:0000439 core TFIIH complex(GO:0000439)
0.1 1.7 GO:0036038 MKS complex(GO:0036038)
0.1 0.8 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.5 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1 1.3 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.4 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 2.1 GO:0051233 spindle midzone(GO:0051233)
0.1 1.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.6 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.7 GO:0016460 myosin II complex(GO:0016460)
0.0 3.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.8 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.5 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 2.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 4.7 GO:0001650 fibrillar center(GO:0001650)
0.0 0.6 GO:0071141 SMAD protein complex(GO:0071141)
0.0 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 4.0 GO:0043209 myelin sheath(GO:0043209)
0.0 0.6 GO:0030863 COP9 signalosome(GO:0008180) cortical cytoskeleton(GO:0030863)
0.0 0.7 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
1.1 4.6 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
1.0 4.1 GO:0003896 DNA primase activity(GO:0003896)
0.9 4.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.8 6.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.8 17.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.7 3.7 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.5 3.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.4 1.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.4 1.2 GO:0016898 D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.3 1.0 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.3 1.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 2.6 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.3 0.8 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.3 2.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.3 1.1 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.3 0.8 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224)
0.3 1.5 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.2 1.4 GO:0051870 methotrexate binding(GO:0051870)
0.2 1.8 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.7 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.2 3.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.2 0.6 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.2 1.8 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 2.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 0.6 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.2 8.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 2.9 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.3 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.4 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.8 GO:0016531 copper chaperone activity(GO:0016531)
0.1 2.5 GO:0000150 recombinase activity(GO:0000150)
0.1 1.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.7 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.1 0.4 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 3.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.6 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.1 1.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 2.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.4 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 10.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.2 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1 4.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.4 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 0.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.2 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 0.6 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 2.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 0.6 GO:0035500 MH2 domain binding(GO:0035500)
0.1 1.5 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 1.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 7.0 GO:0017022 myosin binding(GO:0017022)
0.1 0.5 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.0 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.1 2.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0034711 inhibin binding(GO:0034711)
0.1 3.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.8 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.0 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 1.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 4.5 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0030395 lactose binding(GO:0030395)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0019955 cytokine binding(GO:0019955)
0.0 2.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.3 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 1.3 GO:0019894 kinesin binding(GO:0019894)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.0 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 2.0 GO:0030276 clathrin binding(GO:0030276)
0.0 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 2.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 2.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 7.3 PID BARD1 PATHWAY BARD1 signaling events
0.1 12.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.6 PID ATR PATHWAY ATR signaling pathway
0.1 4.6 PID AURORA A PATHWAY Aurora A signaling
0.1 1.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 4.4 PID E2F PATHWAY E2F transcription factor network
0.0 1.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 2.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.7 PID ARF 3PATHWAY Arf1 pathway
0.0 1.5 PID BMP PATHWAY BMP receptor signaling
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 21.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 8.0 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.3 4.5 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 4.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 3.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.2 6.0 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.2 2.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 5.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 0.8 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 3.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 3.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.6 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 4.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.6 REACTOME KINESINS Genes involved in Kinesins
0.0 0.8 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 2.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.9 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 3.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 3.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction