ISMARA results: ELF2_GABPA

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ELF2_GABPA_ELF5

Z-value: 3.50

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Transcription factors associated with ELF2_GABPA_ELF5

Gene Symbol	Gene ID	Gene Info
ELF2 Ensembl NCBI GeneCards UniProt	ENSG00000109381.15	E74 like ETS transcription factor 2
GABPA Ensembl NCBI GeneCards UniProt	ENSG00000154727.6	GA binding protein transcription factor subunit alpha
ELF5 Ensembl NCBI GeneCards UniProt	ENSG00000135374.5	E74 like ETS transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GABPA	hg19_v2_chr21_+_27107672_27107698	0.94	5.7e-10	Click!
ELF5	hg19_v2_chr11_-_34535332_34535352	0.55	1.2e-02	Click!
ELF2	hg19_v2_chr4_-_140005443_140005650	0.33	1.5e-01	Click!

Activity profile of ELF2_GABPA_ELF5 motif

Sorted Z-values of ELF2_GABPA_ELF5 motif

No targets for ELF2_GABPA_ELF5

Network of associatons between targets according to the STRING database.

First level regulatory network of ELF2_GABPA_ELF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	30.3	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
2.6	26.2	GO:0033183	negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.6	21.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.7	20.5	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
1.9	19.4	GO:1904379	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
1.9	19.1	GO:2001168	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.2	18.7	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
0.2	18.4	GO:0070830	bicellular tight junction assembly(GO:0070830)
0.8	17.8	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
1.5	17.5	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)

Showing 1 to 10 of 1,235 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	85.0	GO:0016607	nuclear speck(GO:0016607)
0.3	40.4	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.2	32.9	GO:0016605	PML body(GO:0016605)
0.2	27.1	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	25.6	GO:0030136	clathrin-coated vesicle(GO:0030136)
0.6	22.3	GO:0031105	septin complex(GO:0031105)
0.3	22.0	GO:0001533	cornified envelope(GO:0001533)
0.1	20.0	GO:0015629	actin cytoskeleton(GO:0015629)
1.6	19.3	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	19.3	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)

Showing 1 to 10 of 454 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	125.5	GO:0003700	transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2	113.0	GO:0045296	cadherin binding(GO:0045296)
0.3	41.4	GO:0002039	p53 binding(GO:0002039)
0.1	37.5	GO:0008022	protein C-terminus binding(GO:0008022)
1.5	29.4	GO:0008179	adenylate cyclase binding(GO:0008179)
0.1	28.9	GO:0032561	guanyl ribonucleotide binding(GO:0032561)
0.2	28.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	26.2	GO:0061659	ubiquitin-like protein ligase activity(GO:0061659)
0.4	24.4	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.1	24.3	GO:0051015	actin filament binding(GO:0051015)

Showing 1 to 10 of 723 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	54.7	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.5	36.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.3	30.6	PID CDC42 PATHWAY	CDC42 signaling events
0.3	25.5	PID FOXO PATHWAY	FoxO family signaling
0.4	25.0	PID INSULIN PATHWAY	Insulin Pathway
0.2	15.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.6	15.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3	15.0	PID BARD1 PATHWAY	BARD1 signaling events
0.1	14.7	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	14.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Showing 1 to 10 of 126 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	109.9	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.6	40.0	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	32.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3	24.5	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	22.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.4	21.3	REACTOME DOUBLE STRAND BREAK REPAIR	Genes involved in Double-Strand Break Repair
0.4	21.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.4	20.0	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.3	18.4	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.4	17.8	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)

Showing 1 to 10 of 165 entries

Results for ELF2_GABPA_ELF5

Z-value: 3.50

Motif logo

Transcription factors associated with ELF2_GABPA_ELF5

Activity-expression correlation:

Activity profile of ELF2_GABPA_ELF5 motif

Sorted Z-values of ELF2_GABPA_ELF5 motif

No targets for ELF2_GABPA_ELF5

Network of associatons between targets according to the STRING database.

First level regulatory network of ELF2_GABPA_ELF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: