ISMARA results: EN2_GBX2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EN2_GBX2_LBX2

Z-value: 0.99

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol	Gene ID	Gene Info
EN2 Ensembl NCBI GeneCards UniProt	ENSG00000164778.4	engrailed homeobox 2
GBX2 Ensembl NCBI GeneCards UniProt	ENSG00000168505.6	gastrulation brain homeobox 2
LBX2 Ensembl NCBI GeneCards UniProt	ENSG00000179528.11	ladybird homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GBX2	hg19_v2_chr2_-_237076992_237077012	-0.87	7.3e-07	Click!
LBX2	hg19_v2_chr2_-_74730430_74730451	-0.85	2.2e-06	Click!
EN2	hg19_v2_chr7_+_155250824_155250824	-0.72	3.5e-04	Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

No targets for EN2_GBX2_LBX2

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	3.0	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.1	2.8	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.1	2.8	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.1	2.4	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.1	1.5	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	1.4	GO:0009301	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1	1.1	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	1.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	1.1	GO:0006458	'de novo' protein folding(GO:0006458)
0.0	1.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)

Showing 1 to 10 of 48 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
2.9	GO:0008023	transcription elongation factor complex(GO:0008023)
2.8	GO:0005796	Golgi lumen(GO:0005796)
1.1	GO:0031258	lamellipodium membrane(GO:0031258)
1.0	GO:0000786	nucleosome(GO:0000786)
1.0	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.7	GO:0001673	male germ cell nucleus(GO:0001673)
0.7	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.6	GO:0071565	nBAF complex(GO:0071565)
0.6	GO:0032839	dendrite cytoplasm(GO:0032839)
0.5	GO:0001518	voltage-gated sodium channel complex(GO:0001518)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.6	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.6	2.8	GO:0030197	extracellular matrix constituent, lubricant activity(GO:0030197)
0.1	2.8	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	1.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.1	1.1	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0	1.1	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	1.0	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	0.7	GO:0017161	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0	0.7	GO:0019871	potassium channel inhibitor activity(GO:0019870) sodium channel inhibitor activity(GO:0019871)
0.0	0.7	GO:0008179	adenylate cyclase binding(GO:0008179)

Showing 1 to 10 of 21 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	3.7	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.1	2.8	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.6	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	2.8	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	2.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	1.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.4	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	1.1	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.7	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.6	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 10 entries

Results for EN2_GBX2_LBX2

Z-value: 0.99

Motif logo

Transcription factors associated with EN2_GBX2_LBX2

Activity-expression correlation:

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

No targets for EN2_GBX2_LBX2

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: