ISMARA results: EPAS1

Project

avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for EPAS1_BCL3

Z-value: 2.50

Motif logo

Transcription factors associated with EPAS1_BCL3

Gene Symbol	Gene ID	Gene Info
EPAS1 Ensembl NCBI GeneCards UniProt	ENSG00000116016.9	endothelial PAS domain protein 1
BCL3 Ensembl NCBI GeneCards UniProt	ENSG00000069399.8	BCL3 transcription coactivator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EPAS1	hg19_v2_chr2_+_46524537_46524553	-0.82	8.8e-06	Click!
BCL3	hg19_v2_chr19_+_45251804_45251840	0.19	4.3e-01	Click!

Activity profile of EPAS1_BCL3 motif

Sorted Z-values of EPAS1_BCL3 motif

No targets for EPAS1_BCL3

Network of associatons between targets according to the STRING database.

First level regulatory network of EPAS1_BCL3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.2	6.7	GO:1902173	negative regulation of keratinocyte apoptotic process(GO:1902173)
0.2	5.0	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.2	4.2	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1	4.2	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.4	4.0	GO:1904327	protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.3	4.0	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.1	3.4	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
1.0	3.1	GO:1990764	regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1	3.0	GO:0051412	response to corticosterone(GO:0051412)
0.2	2.8	GO:1902414	protein localization to cell junction(GO:1902414)

Showing 1 to 10 of 354 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.7	GO:0043202	lysosomal lumen(GO:0043202)
0.0	4.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	4.5	GO:0030315	T-tubule(GO:0030315)
0.3	4.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	3.7	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.1	3.7	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	3.6	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.0	3.4	GO:0031225	anchored component of membrane(GO:0031225)
0.2	3.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	2.8	GO:0043020	NADPH oxidase complex(GO:0043020)

Showing 1 to 10 of 103 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	7.4	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	5.4	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1	4.9	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.2	3.9	GO:0015643	toxic substance binding(GO:0015643)
0.3	3.8	GO:0038132	neuregulin binding(GO:0038132)
0.2	3.7	GO:0048185	activin binding(GO:0048185)
0.0	3.5	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	3.5	GO:0008013	beta-catenin binding(GO:0008013)
0.0	3.3	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 242 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	5.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	3.8	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	3.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	3.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	3.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	2.0	PID BMP PATHWAY	BMP receptor signaling
0.1	1.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	1.5	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0	3.5	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	3.1	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.1	2.9	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	2.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	2.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	2.6	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	2.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	1.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	1.6	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac

Showing 1 to 10 of 65 entries

Results for EPAS1_BCL3

Z-value: 2.50

Motif logo

Transcription factors associated with EPAS1_BCL3

Activity-expression correlation:

Activity profile of EPAS1_BCL3 motif

Sorted Z-values of EPAS1_BCL3 motif

No targets for EPAS1_BCL3

Network of associatons between targets according to the STRING database.

First level regulatory network of EPAS1_BCL3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: