ISMARA results: ETV1_ERF_FEV

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ETV1_ERF_FEV_ELF1

Z-value: 1.64

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Transcription factors associated with ETV1_ERF_FEV_ELF1

Gene Symbol	Gene ID	Gene Info
ETV1 Ensembl NCBI GeneCards UniProt	ENSG00000006468.9	ETS variant transcription factor 1
ERF Ensembl NCBI GeneCards UniProt	ENSG00000105722.5	ETS2 repressor factor
FEV Ensembl NCBI GeneCards UniProt	ENSG00000163497.2	FEV transcription factor, ETS family member
ELF1 Ensembl NCBI GeneCards UniProt	ENSG00000120690.9	E74 like ETS transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ELF1	hg19_v2_chr13_-_41593425_41593480	-0.68	1.0e-03	Click!
ETV1	hg19_v2_chr7_-_14029515_14029642	0.60	4.7e-03	Click!
ERF	hg19_v2_chr19_-_42758040_42758064	0.58	7.5e-03	Click!
FEV	hg19_v2_chr2_-_219850277_219850379	0.18	4.5e-01	Click!

Activity profile of ETV1_ERF_FEV_ELF1 motif

Sorted Z-values of ETV1_ERF_FEV_ELF1 motif

No targets for ETV1_ERF_FEV_ELF1

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV1_ERF_FEV_ELF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	14.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.5	12.2	GO:0031167	rRNA methylation(GO:0031167)
0.2	11.1	GO:0006270	DNA replication initiation(GO:0006270)
0.1	8.9	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.2	8.6	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.3	8.4	GO:0006744	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2	8.1	GO:0034724	DNA replication-independent nucleosome organization(GO:0034724)
0.1	8.1	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.4	7.9	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.7	7.1	GO:0000821	regulation of arginine metabolic process(GO:0000821)

Showing 1 to 10 of 541 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	13.8	GO:0005739	mitochondrion(GO:0005739)
0.0	13.2	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	10.2	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.1	9.4	GO:0005871	kinesin complex(GO:0005871)
0.1	9.4	GO:0005776	autophagosome(GO:0005776)
0.1	8.2	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	7.9	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1	7.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	7.3	GO:0005759	mitochondrial matrix(GO:0005759)
0.8	7.0	GO:0005683	U7 snRNP(GO:0005683)

Showing 1 to 10 of 240 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.1	GO:0003735	structural constituent of ribosome(GO:0003735)
2.8	14.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
1.6	9.7	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
1.6	8.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.3	7.3	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	6.4	GO:0003777	microtubule motor activity(GO:0003777)
0.0	6.3	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.5	6.2	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
2.0	6.0	GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
1.9	5.7	GO:0015039	ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731)

Showing 1 to 10 of 344 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.1	10.4	PID AURORA B PATHWAY	Aurora B signaling
0.1	8.3	ST GAQ PATHWAY	G alpha q Pathway
0.1	5.9	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1	3.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	2.8	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	2.5	PID AURORA A PATHWAY	Aurora A signaling
0.0	2.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	2.4	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.3	PID ATR PATHWAY	ATR signaling pathway

Showing 1 to 10 of 46 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.8	REACTOME METABOLISM OF CARBOHYDRATES	Genes involved in Metabolism of carbohydrates
0.1	12.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	11.7	REACTOME KINESINS	Genes involved in Kinesins
0.1	11.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.3	9.7	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.1	9.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	8.1	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2	7.1	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	6.9	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.4	6.5	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex

Showing 1 to 10 of 85 entries

Results for ETV1_ERF_FEV_ELF1

Z-value: 1.64

Motif logo

Transcription factors associated with ETV1_ERF_FEV_ELF1

Activity-expression correlation:

Activity profile of ETV1_ERF_FEV_ELF1 motif

Sorted Z-values of ETV1_ERF_FEV_ELF1 motif

No targets for ETV1_ERF_FEV_ELF1

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV1_ERF_FEV_ELF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: