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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOSL1

Z-value: 5.92

Motif logo

Transcription factors associated with FOSL1

Gene Symbol Gene ID Gene Info
ENSG00000175592.4 FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOSL1hg19_v2_chr11_-_65667884_656678950.946.5e-10Click!

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
14.3 42.9 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
8.4 25.1 GO:0071258 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
6.0 42.1 GO:0071461 cellular response to redox state(GO:0071461)
5.9 35.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
4.7 23.4 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
4.6 13.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
4.3 13.0 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
4.1 32.8 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
3.5 31.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
3.0 9.1 GO:0046521 sphingoid catabolic process(GO:0046521)
2.9 104.5 GO:0031581 hemidesmosome assembly(GO:0031581)
2.9 20.1 GO:1903575 cornified envelope assembly(GO:1903575)
2.8 98.4 GO:0061436 establishment of skin barrier(GO:0061436)
2.7 8.1 GO:0006117 acetaldehyde metabolic process(GO:0006117)
2.6 76.6 GO:0051798 positive regulation of hair follicle development(GO:0051798)
2.5 5.1 GO:1903923 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
2.5 7.4 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
2.3 15.9 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
2.3 9.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
2.2 11.0 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
2.1 10.5 GO:0030822 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
2.0 10.1 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
2.0 16.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.9 7.6 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
1.9 9.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
1.9 5.7 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
1.8 10.9 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.7 13.9 GO:0046952 ketone body catabolic process(GO:0046952)
1.5 33.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
1.4 4.3 GO:0003274 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) endocardial cushion fusion(GO:0003274)
1.4 9.5 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.4 8.2 GO:0098886 modification of dendritic spine(GO:0098886)
1.3 5.3 GO:0006218 uridine catabolic process(GO:0006218)
1.3 17.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
1.3 10.4 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
1.3 25.6 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
1.2 31.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
1.2 13.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.2 10.8 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.1 9.2 GO:0007296 vitellogenesis(GO:0007296)
1.1 4.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.1 5.7 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
1.1 5.6 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.1 10.9 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
1.0 27.0 GO:0030502 negative regulation of bone mineralization(GO:0030502)
1.0 14.5 GO:0002191 cap-dependent translational initiation(GO:0002191)
1.0 3.8 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.9 6.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.9 17.9 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.9 12.3 GO:0007320 insemination(GO:0007320)
0.8 5.9 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.8 5.5 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.8 17.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.8 57.1 GO:0018149 peptide cross-linking(GO:0018149)
0.7 15.0 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 4.4 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.7 3.6 GO:0031959 mineralocorticoid receptor signaling pathway(GO:0031959)
0.7 14.3 GO:0016540 protein autoprocessing(GO:0016540)
0.7 4.2 GO:0030421 defecation(GO:0030421)
0.7 2.1 GO:1901656 glycoside transport(GO:1901656)
0.7 8.8 GO:0006477 protein sulfation(GO:0006477)
0.7 3.3 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.7 3.9 GO:0044805 late nucleophagy(GO:0044805)
0.6 1.8 GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515)
0.6 3.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.6 14.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.6 17.4 GO:0032060 bleb assembly(GO:0032060)
0.6 8.4 GO:0035092 sperm chromatin condensation(GO:0035092)
0.6 3.9 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.6 2.8 GO:1904383 response to sodium phosphate(GO:1904383)
0.5 20.9 GO:0042730 fibrinolysis(GO:0042730)
0.5 6.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 6.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.5 1.0 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.5 14.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.5 1.4 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.5 1.4 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.5 20.4 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.4 1.3 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369) positive regulation of response to alcohol(GO:1901421)
0.4 3.0 GO:0006196 AMP catabolic process(GO:0006196)
0.4 6.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.4 7.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.4 8.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.4 2.4 GO:0048388 endosomal lumen acidification(GO:0048388)
0.4 2.4 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.4 18.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.4 7.1 GO:0001765 membrane raft assembly(GO:0001765)
0.4 4.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.4 5.1 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.4 10.8 GO:0035855 megakaryocyte development(GO:0035855)
0.3 1.0 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.3 4.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 1.2 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.3 3.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.3 9.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 1.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.2 4.0 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 5.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.2 4.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 2.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.2 5.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 5.5 GO:0051639 actin filament network formation(GO:0051639)
0.2 2.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 0.7 GO:0038178 complement component C5a signaling pathway(GO:0038178) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.2 1.5 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.2 1.1 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.2 2.1 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 3.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.2 3.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 5.1 GO:0003334 keratinocyte development(GO:0003334)
0.2 1.6 GO:0023021 termination of signal transduction(GO:0023021)
0.2 9.0 GO:0050873 brown fat cell differentiation(GO:0050873)
0.2 4.7 GO:0042481 regulation of odontogenesis(GO:0042481)
0.2 1.7 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.2 5.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.2 9.7 GO:0034629 cellular protein complex localization(GO:0034629)
0.2 5.2 GO:0097186 amelogenesis(GO:0097186)
0.2 1.4 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.2 1.7 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.2 0.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.2 1.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.2 3.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 4.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.1 5.0 GO:0015695 organic cation transport(GO:0015695)
0.1 1.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 2.8 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 7.0 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.1 2.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 5.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 5.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 2.1 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.7 GO:0010820 release of cytoplasmic sequestered NF-kappaB(GO:0008588) positive regulation of T cell chemotaxis(GO:0010820)
0.1 1.3 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.1 4.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 0.2 GO:0071500 cellular response to nitrosative stress(GO:0071500) regulation of determination of dorsal identity(GO:2000015)
0.1 9.8 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.1 1.5 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 1.1 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.7 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 1.6 GO:0035966 response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966)
0.1 7.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 4.5 GO:0010863 positive regulation of phospholipase C activity(GO:0010863)
0.1 2.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 4.3 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.1 2.8 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 0.4 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.8 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.1 10.7 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 1.9 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 2.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 1.8 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 12.5 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 0.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.1 0.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.6 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 1.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 3.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.1 3.9 GO:0006953 acute-phase response(GO:0006953)
0.1 3.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.1 5.2 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.1 0.1 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 2.7 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 6.4 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 2.8 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 1.7 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.9 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 2.4 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 3.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 3.0 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 1.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.5 GO:0010842 retina layer formation(GO:0010842)
0.0 4.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 4.6 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.5 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 9.3 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.1 GO:2001053 mesenchymal cell apoptotic process(GO:0097152) regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.0 6.1 GO:0007030 Golgi organization(GO:0007030)
0.0 1.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
0.0 1.0 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 2.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.8 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 1.2 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 4.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 7.1 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 2.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.0 0.8 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 2.2 GO:0051607 defense response to virus(GO:0051607)
0.0 2.8 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:0033037 polysaccharide localization(GO:0033037)
0.0 2.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 6.3 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.3 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.7 GO:0009798 axis specification(GO:0009798)
0.0 0.6 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 1.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 1.4 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.7 GO:0035113 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 30.0 GO:0005607 laminin-2 complex(GO:0005607)
5.4 59.7 GO:0005610 laminin-5 complex(GO:0005610)
3.1 18.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
2.7 8.2 GO:0097444 spine apparatus(GO:0097444)
2.7 8.1 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
2.5 7.6 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
1.9 5.6 GO:1990032 parallel fiber(GO:1990032)
1.7 5.1 GO:0034515 proteasome storage granule(GO:0034515)
1.5 114.1 GO:0001533 cornified envelope(GO:0001533)
1.5 27.0 GO:0031089 platelet dense granule lumen(GO:0031089)
1.4 7.0 GO:0070435 Shc-EGFR complex(GO:0070435)
1.3 10.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
1.3 44.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
1.2 4.8 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
1.1 5.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.1 6.7 GO:0097513 myosin II filament(GO:0097513)
1.1 5.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
1.0 9.7 GO:0005827 polar microtubule(GO:0005827)
0.8 25.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.8 14.8 GO:0097512 cardiac myofibril(GO:0097512)
0.6 3.9 GO:0031673 H zone(GO:0031673)
0.6 4.6 GO:0070545 PeBoW complex(GO:0070545)
0.6 12.1 GO:0030056 hemidesmosome(GO:0030056)
0.6 5.7 GO:1990812 growth cone filopodium(GO:1990812)
0.5 14.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.5 13.8 GO:0005922 connexon complex(GO:0005922)
0.5 2.0 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.4 5.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.4 43.3 GO:0045178 basal part of cell(GO:0045178)
0.4 4.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.4 13.2 GO:0031143 pseudopodium(GO:0031143)
0.4 5.2 GO:0030057 desmosome(GO:0030057)
0.4 16.0 GO:0032590 dendrite membrane(GO:0032590)
0.3 6.1 GO:0010369 chromocenter(GO:0010369)
0.3 17.3 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 0.8 GO:0071203 WASH complex(GO:0071203)
0.2 31.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.2 4.2 GO:0031209 SCAR complex(GO:0031209)
0.2 32.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 2.5 GO:0016600 flotillin complex(GO:0016600)
0.2 11.9 GO:0016592 mediator complex(GO:0016592)
0.2 4.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 3.6 GO:0061700 GATOR2 complex(GO:0061700)
0.2 19.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.2 1.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 3.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 1.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.2 1.4 GO:0097452 GAIT complex(GO:0097452)
0.2 4.0 GO:0031528 microvillus membrane(GO:0031528)
0.2 5.0 GO:0071437 invadopodium(GO:0071437)
0.2 1.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 1.2 GO:1990635 proximal dendrite(GO:1990635)
0.1 5.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 4.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 3.4 GO:0043034 costamere(GO:0043034)
0.1 1.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 4.1 GO:0001891 phagocytic cup(GO:0001891)
0.1 3.6 GO:0031904 endosome lumen(GO:0031904)
0.1 1.6 GO:0030478 actin cap(GO:0030478)
0.1 4.8 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.8 GO:0097470 ribbon synapse(GO:0097470)
0.1 3.0 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 10.4 GO:0005902 microvillus(GO:0005902)
0.1 1.6 GO:0005883 neurofilament(GO:0005883)
0.1 2.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 24.2 GO:0001650 fibrillar center(GO:0001650)
0.1 14.3 GO:0005604 basement membrane(GO:0005604)
0.1 6.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 3.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.9 GO:0000421 autophagosome membrane(GO:0000421)
0.1 11.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 8.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 9.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 4.4 GO:0005771 multivesicular body(GO:0005771)
0.1 14.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 3.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 26.4 GO:0005769 early endosome(GO:0005769)
0.0 8.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.3 GO:0005882 intermediate filament(GO:0005882)
0.0 1.2 GO:0071564 npBAF complex(GO:0071564)
0.0 3.8 GO:0005811 lipid particle(GO:0005811)
0.0 2.2 GO:0030139 endocytic vesicle(GO:0030139)
0.0 3.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.0 GO:0002102 podosome(GO:0002102)
0.0 3.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 69.6 GO:0005615 extracellular space(GO:0005615)
0.0 4.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 4.3 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 20.0 GO:0016607 nuclear speck(GO:0016607)
0.0 8.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 7.1 GO:0030027 lamellipodium(GO:0030027)
0.0 7.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 5.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 4.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.6 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.8 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.8 78.5 GO:0042289 MHC class II protein binding(GO:0042289)
9.1 27.4 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
3.7 25.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
3.5 42.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
3.5 13.9 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
3.4 23.7 GO:0004992 platelet activating factor receptor activity(GO:0004992)
2.4 16.8 GO:1990254 keratin filament binding(GO:1990254)
2.2 8.7 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
1.9 5.7 GO:0061663 NEDD8 ligase activity(GO:0061663)
1.8 18.4 GO:0045545 syndecan binding(GO:0045545)
1.7 10.1 GO:1903135 cupric ion binding(GO:1903135)
1.6 14.6 GO:0048408 epidermal growth factor binding(GO:0048408)
1.6 6.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
1.5 33.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
1.5 6.1 GO:1990175 EH domain binding(GO:1990175)
1.3 9.4 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
1.3 9.1 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
1.3 17.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.2 14.8 GO:0030280 structural constituent of epidermis(GO:0030280)
1.1 4.3 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
1.1 5.3 GO:0004850 uridine phosphorylase activity(GO:0004850)
1.1 14.8 GO:0038132 neuregulin binding(GO:0038132)
1.0 17.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.0 3.8 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.9 6.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.8 4.2 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.8 9.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.8 5.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.8 15.0 GO:0030957 Tat protein binding(GO:0030957)
0.7 8.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.7 16.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.7 101.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.6 1.8 GO:0031775 lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039)
0.6 10.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.6 23.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 5.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.5 7.0 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.5 2.7 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.5 4.8 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.4 2.6 GO:0050436 microfibril binding(GO:0050436)
0.4 124.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 2.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 6.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.4 3.6 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.4 5.0 GO:0019534 toxin transporter activity(GO:0019534)
0.4 9.4 GO:0044548 S100 protein binding(GO:0044548)
0.4 4.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.4 13.2 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.3 1.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.3 18.4 GO:0030332 cyclin binding(GO:0030332)
0.3 6.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 1.2 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.3 3.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 1.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 6.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 5.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 52.4 GO:0008201 heparin binding(GO:0008201)
0.2 21.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 5.1 GO:0048156 tau protein binding(GO:0048156)
0.2 10.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 0.7 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.2 1.1 GO:1990460 leptin receptor binding(GO:1990460)
0.2 2.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 19.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 4.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 0.8 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.2 2.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 28.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 6.8 GO:0008009 chemokine activity(GO:0008009)
0.2 7.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 2.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 2.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 3.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 5.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 50.6 GO:0030674 protein binding, bridging(GO:0030674)
0.2 35.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.3 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 8.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 3.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 6.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 8.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 2.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 3.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.5 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 3.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 2.5 GO:0017166 vinculin binding(GO:0017166)
0.1 2.2 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 18.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.8 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.4 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 2.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 3.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 3.2 GO:0030275 LRR domain binding(GO:0030275)
0.1 0.7 GO:0004359 glutaminase activity(GO:0004359)
0.1 9.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 4.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 4.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 7.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 2.0 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 6.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 4.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 5.2 GO:0001618 virus receptor activity(GO:0001618)
0.0 2.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 11.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 3.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 13.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 3.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 27.6 GO:0003779 actin binding(GO:0003779)
0.0 5.9 GO:0019838 growth factor binding(GO:0019838)
0.0 1.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 23.1 GO:0003682 chromatin binding(GO:0003682)
0.0 1.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.3 GO:0004875 complement receptor activity(GO:0004875)
0.0 4.8 GO:0001047 core promoter binding(GO:0001047)
0.0 2.4 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 10.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.1 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.0 1.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 11.1 GO:0008134 transcription factor binding(GO:0008134)
0.0 1.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 3.9 GO:0044325 ion channel binding(GO:0044325)
0.0 1.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.6 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 1.7 GO:0005262 calcium channel activity(GO:0005262)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 101.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.9 66.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.8 136.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.4 3.6 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.4 10.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.4 10.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.3 13.0 PID CD40 PATHWAY CD40/CD40L signaling
0.3 21.7 PID RAS PATHWAY Regulation of Ras family activation
0.3 43.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.3 10.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3 20.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.3 14.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.3 22.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.3 2.8 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 7.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.2 14.7 PID IL1 PATHWAY IL1-mediated signaling events
0.2 2.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 4.8 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 16.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 14.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 9.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 12.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.2 7.7 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 12.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 4.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 1.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 8.8 PID ARF6 PATHWAY Arf6 signaling events
0.1 39.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.2 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 3.0 PID ARF 3PATHWAY Arf1 pathway
0.1 2.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 8.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 4.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 12.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 1.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 17.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 42.9 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.7 116.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.6 18.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.6 14.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.6 13.8 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.5 13.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 14.6 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.5 10.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 9.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 8.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 9.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.3 6.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.3 5.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 6.0 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 24.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 4.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 25.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.2 7.9 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 6.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 9.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 13.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 52.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 10.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 4.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 9.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 7.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.1 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 3.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 12.4 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.1 3.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 3.2 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 3.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 3.4 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 2.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 5.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 1.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 3.1 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.1 2.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 2.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 4.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 1.4 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 1.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins