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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOSL1
Z-value: 5.92
Motif logo
Transcription factors associated with FOSL1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FOSL1
|
ENSG00000175592.4 | FOS like 1, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667884_65667895 | 0.94 | 6.5e-10 | Click! |
Activity profile of FOSL1 motif
Sorted Z-values of FOSL1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.3 | 42.9 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 8.4 | 25.1 | GO:0071258 | positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317) |
| 6.0 | 42.1 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 5.9 | 35.2 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 4.7 | 23.4 | GO:0018153 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 4.6 | 13.7 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 4.3 | 13.0 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 4.1 | 32.8 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 3.5 | 31.8 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 3.0 | 9.1 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 2.9 | 104.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 2.9 | 20.1 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 2.8 | 98.4 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 2.7 | 8.1 | GO:0006117 | acetaldehyde metabolic process(GO:0006117) |
| 2.6 | 76.6 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 2.5 | 5.1 | GO:1903923 | protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923) |
| 2.5 | 7.4 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 2.3 | 15.9 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 2.3 | 9.0 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 2.2 | 11.0 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 2.1 | 10.5 | GO:0030822 | positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123) |
| 2.0 | 10.1 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535) |
| 2.0 | 16.1 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 1.9 | 7.6 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 1.9 | 9.5 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 1.9 | 5.7 | GO:0071301 | cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404) |
| 1.8 | 10.9 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 1.7 | 13.9 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 1.5 | 33.8 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 1.4 | 4.3 | GO:0003274 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) endocardial cushion fusion(GO:0003274) |
| 1.4 | 9.5 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 1.4 | 8.2 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 1.3 | 5.3 | GO:0006218 | uridine catabolic process(GO:0006218) |
| 1.3 | 17.1 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 1.3 | 10.4 | GO:0051549 | positive regulation of keratinocyte migration(GO:0051549) |
| 1.3 | 25.6 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 1.2 | 31.1 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 1.2 | 13.2 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 1.2 | 10.8 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.1 | 9.2 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.1 | 4.6 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 1.1 | 5.7 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 1.1 | 5.6 | GO:0043553 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 1.1 | 10.9 | GO:0007406 | negative regulation of neuroblast proliferation(GO:0007406) |
| 1.0 | 27.0 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 1.0 | 14.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 1.0 | 3.8 | GO:0034721 | histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721) |
| 0.9 | 6.5 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.9 | 17.9 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.9 | 12.3 | GO:0007320 | insemination(GO:0007320) |
| 0.8 | 5.9 | GO:0072674 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.8 | 5.5 | GO:0060449 | bud elongation involved in lung branching(GO:0060449) |
| 0.8 | 17.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.8 | 57.1 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.7 | 15.0 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.7 | 4.4 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.7 | 3.6 | GO:0031959 | mineralocorticoid receptor signaling pathway(GO:0031959) |
| 0.7 | 14.3 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.7 | 4.2 | GO:0030421 | defecation(GO:0030421) |
| 0.7 | 2.1 | GO:1901656 | glycoside transport(GO:1901656) |
| 0.7 | 8.8 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.7 | 3.3 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.7 | 3.9 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.6 | 1.8 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515) |
| 0.6 | 3.6 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.6 | 14.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.6 | 17.4 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.6 | 8.4 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 0.6 | 3.9 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.6 | 2.8 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.5 | 20.9 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.5 | 6.2 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.5 | 6.4 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.5 | 1.0 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.5 | 14.8 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.5 | 1.4 | GO:0002372 | myeloid dendritic cell cytokine production(GO:0002372) |
| 0.5 | 1.4 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.5 | 20.4 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.4 | 1.3 | GO:0010980 | regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369) positive regulation of response to alcohol(GO:1901421) |
| 0.4 | 3.0 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.4 | 6.0 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.4 | 7.1 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.4 | 8.4 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.4 | 2.4 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.4 | 2.4 | GO:0009181 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) |
| 0.4 | 18.4 | GO:0031954 | positive regulation of protein autophosphorylation(GO:0031954) |
| 0.4 | 7.1 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.4 | 4.8 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.4 | 5.1 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.4 | 10.8 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.3 | 1.0 | GO:0061394 | regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) |
| 0.3 | 4.4 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.3 | 1.2 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 0.3 | 3.0 | GO:0001866 | NK T cell proliferation(GO:0001866) |
| 0.3 | 9.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.3 | 1.1 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.2 | 4.0 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.2 | 5.7 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.2 | 4.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 2.2 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.2 | 5.2 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.2 | 5.5 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 2.6 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 0.7 | GO:0038178 | complement component C5a signaling pathway(GO:0038178) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623) |
| 0.2 | 1.5 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.2 | 1.1 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.2 | 2.1 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.2 | 3.2 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) |
| 0.2 | 3.6 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.2 | 5.1 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.2 | 1.6 | GO:0023021 | termination of signal transduction(GO:0023021) |
| 0.2 | 9.0 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.2 | 4.7 | GO:0042481 | regulation of odontogenesis(GO:0042481) |
| 0.2 | 1.7 | GO:0042636 | negative regulation of hair cycle(GO:0042636) |
| 0.2 | 5.5 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 9.7 | GO:0034629 | cellular protein complex localization(GO:0034629) |
| 0.2 | 5.2 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.2 | 1.4 | GO:0060742 | epithelial cell differentiation involved in prostate gland development(GO:0060742) |
| 0.2 | 1.7 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.2 | 0.7 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.2 | 1.0 | GO:0010591 | regulation of lamellipodium assembly(GO:0010591) |
| 0.2 | 3.5 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.2 | 4.1 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.1 | 5.0 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.1 | 1.7 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.1 | 2.8 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.1 | 7.0 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.1 | 2.6 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.1 | 5.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 5.0 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 2.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.1 | 0.7 | GO:0010820 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) positive regulation of T cell chemotaxis(GO:0010820) |
| 0.1 | 1.3 | GO:0010626 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.1 | 4.6 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 0.2 | GO:0071500 | cellular response to nitrosative stress(GO:0071500) regulation of determination of dorsal identity(GO:2000015) |
| 0.1 | 9.8 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 0.1 | 1.5 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.1 | 1.1 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.1 | 0.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 1.6 | GO:0035966 | response to unfolded protein(GO:0006986) response to topologically incorrect protein(GO:0035966) |
| 0.1 | 7.2 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 1.6 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 4.5 | GO:0010863 | positive regulation of phospholipase C activity(GO:0010863) |
| 0.1 | 2.8 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 4.3 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.1 | 2.8 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.4 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.1 | 0.8 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.1 | 10.7 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 1.9 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.1 | 2.2 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 1.8 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.1 | 12.5 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.1 | 0.6 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 0.9 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 0.6 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.1 | 0.8 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 1.1 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 3.3 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.1 | 3.9 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 3.7 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.1 | 5.2 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.1 | 0.1 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 2.7 | GO:0006693 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
| 0.0 | 6.4 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630) |
| 0.0 | 2.8 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 1.7 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.9 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 2.4 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.0 | 3.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 1.8 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.3 | GO:0010759 | positive regulation of macrophage chemotaxis(GO:0010759) |
| 0.0 | 3.0 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 1.7 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.5 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 4.5 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 4.6 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 0.5 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.0 | 0.1 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.0 | 9.3 | GO:0060828 | regulation of canonical Wnt signaling pathway(GO:0060828) |
| 0.0 | 0.1 | GO:2001053 | mesenchymal cell apoptotic process(GO:0097152) regulation of mesenchymal cell apoptotic process(GO:2001053) negative regulation of mesenchymal cell apoptotic process(GO:2001054) |
| 0.0 | 6.1 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 1.5 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.2 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.0 | 1.0 | GO:0032461 | positive regulation of protein oligomerization(GO:0032461) |
| 0.0 | 2.1 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.8 | GO:1990126 | retrograde transport, endosome to plasma membrane(GO:1990126) |
| 0.0 | 1.2 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.0 | 4.3 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 7.1 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.0 | 2.7 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.0 | 0.8 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.0 | 0.8 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 2.2 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 2.8 | GO:0030038 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.0 | 0.1 | GO:0033037 | polysaccharide localization(GO:0033037) |
| 0.0 | 2.2 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.0 | 6.3 | GO:0006457 | protein folding(GO:0006457) |
| 0.0 | 0.1 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.0 | 0.2 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.3 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.0 | 0.7 | GO:0009798 | axis specification(GO:0009798) |
| 0.0 | 0.6 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 1.2 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 1.4 | GO:0006687 | glycosphingolipid metabolic process(GO:0006687) |
| 0.0 | 0.7 | GO:0035113 | embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 30.0 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 5.4 | 59.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 3.1 | 18.4 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 2.7 | 8.2 | GO:0097444 | spine apparatus(GO:0097444) |
| 2.7 | 8.1 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 2.5 | 7.6 | GO:0097489 | multivesicular body, internal vesicle lumen(GO:0097489) |
| 1.9 | 5.6 | GO:1990032 | parallel fiber(GO:1990032) |
| 1.7 | 5.1 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 1.5 | 114.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.5 | 27.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 1.4 | 7.0 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 1.3 | 10.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.3 | 44.1 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 1.2 | 4.8 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 1.1 | 5.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 1.1 | 6.7 | GO:0097513 | myosin II filament(GO:0097513) |
| 1.1 | 5.5 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 1.0 | 9.7 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.8 | 25.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.8 | 14.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.6 | 3.9 | GO:0031673 | H zone(GO:0031673) |
| 0.6 | 4.6 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.6 | 12.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.6 | 5.7 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.5 | 14.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.5 | 13.8 | GO:0005922 | connexon complex(GO:0005922) |
| 0.5 | 2.0 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.4 | 5.2 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.4 | 43.3 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.4 | 4.3 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.4 | 13.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.4 | 5.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.4 | 16.0 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.3 | 6.1 | GO:0010369 | chromocenter(GO:0010369) |
| 0.3 | 17.3 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.3 | 0.8 | GO:0071203 | WASH complex(GO:0071203) |
| 0.2 | 31.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.2 | 4.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 32.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.2 | 2.5 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.2 | 11.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.2 | 4.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 3.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.2 | 19.5 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 1.4 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.2 | 3.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.2 | 1.1 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.2 | 1.4 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.2 | 4.0 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.2 | 5.0 | GO:0071437 | invadopodium(GO:0071437) |
| 0.2 | 1.2 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.1 | 1.2 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 5.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 4.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 3.4 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 1.1 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 4.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 3.6 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 1.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 4.8 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 1.8 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 3.0 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 10.4 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 1.6 | GO:0005883 | neurofilament(GO:0005883) |
| 0.1 | 2.6 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 24.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 14.3 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 6.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 3.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 3.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 11.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.2 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 8.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 9.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 4.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 14.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 3.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 3.9 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 26.4 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 8.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 6.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.2 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 3.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.2 | GO:0030139 | endocytic vesicle(GO:0030139) |
| 0.0 | 3.6 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 1.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 2.0 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 3.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 69.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 4.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 4.3 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 20.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 8.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 3.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 7.1 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 7.3 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 1.7 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 2.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 5.8 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 4.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.6 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.8 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 78.5 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 9.1 | 27.4 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 3.7 | 25.8 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 3.5 | 42.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 3.5 | 13.9 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 3.4 | 23.7 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 2.4 | 16.8 | GO:1990254 | keratin filament binding(GO:1990254) |
| 2.2 | 8.7 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
| 1.9 | 5.7 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 1.8 | 18.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 1.7 | 10.1 | GO:1903135 | cupric ion binding(GO:1903135) |
| 1.6 | 14.6 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 1.6 | 6.2 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 1.5 | 33.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 1.5 | 6.1 | GO:1990175 | EH domain binding(GO:1990175) |
| 1.3 | 9.4 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 1.3 | 9.1 | GO:0008481 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 1.3 | 17.8 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 1.2 | 14.8 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 1.1 | 4.3 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 1.1 | 5.3 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 1.1 | 14.8 | GO:0038132 | neuregulin binding(GO:0038132) |
| 1.0 | 17.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.0 | 3.8 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.9 | 6.4 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.8 | 4.2 | GO:0051120 | hepoxilin A3 synthase activity(GO:0051120) |
| 0.8 | 9.1 | GO:0004305 | ethanolamine kinase activity(GO:0004305) |
| 0.8 | 5.6 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.8 | 15.0 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.7 | 8.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.7 | 16.1 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.7 | 101.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.6 | 1.8 | GO:0031775 | lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039) |
| 0.6 | 10.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.6 | 23.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.6 | 5.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.5 | 7.0 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.5 | 2.7 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.5 | 4.8 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.4 | 2.6 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.4 | 124.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 2.4 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.4 | 6.5 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.4 | 3.6 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.4 | 5.0 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.4 | 9.4 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.4 | 4.4 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.4 | 13.2 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.3 | 1.4 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.3 | 18.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.3 | 6.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.3 | 1.2 | GO:0032551 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551) |
| 0.3 | 3.0 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 1.5 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.3 | 6.7 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.3 | 5.2 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.2 | 52.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 21.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 5.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.2 | 10.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 0.7 | GO:0004878 | complement component C5a receptor activity(GO:0004878) |
| 0.2 | 1.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.2 | 2.8 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.2 | 19.0 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 4.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 0.8 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.2 | 2.2 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.2 | 28.9 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.2 | 6.8 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.2 | 7.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 0.7 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.2 | 2.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.2 | 2.5 | GO:0008526 | phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526) |
| 0.2 | 3.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 5.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 50.6 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.2 | 35.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.3 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.1 | 8.3 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 3.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 6.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.1 | 8.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 2.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 3.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.5 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.1 | 3.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.1 | 1.6 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 2.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 2.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.1 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 3.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 18.7 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 0.8 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 1.4 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.1 | 2.4 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 3.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.1 | 3.2 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 0.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 9.5 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 4.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 4.0 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 2.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 1.4 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 7.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.4 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 2.0 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 6.2 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.1 | 4.5 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 5.2 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 2.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 11.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.4 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 3.3 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 1.8 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 1.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.9 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 13.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 3.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 1.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 27.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 5.9 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 1.0 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 23.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.5 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 0.3 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.0 | 4.8 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 2.4 | GO:0004520 | endodeoxyribonuclease activity(GO:0004520) |
| 0.0 | 10.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 2.1 | GO:0051119 | sugar transmembrane transporter activity(GO:0051119) |
| 0.0 | 1.2 | GO:0008081 | phosphoric diester hydrolase activity(GO:0008081) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 11.1 | GO:0008134 | transcription factor binding(GO:0008134) |
| 0.0 | 1.3 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.6 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 3.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 1.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.6 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.2 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 1.2 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 0.3 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.1 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.0 | 1.7 | GO:0005262 | calcium channel activity(GO:0005262) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 101.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.9 | 66.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.8 | 136.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.4 | 3.6 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.4 | 10.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.4 | 10.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 13.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.3 | 21.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 43.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 10.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 20.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.3 | 14.0 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 22.7 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.3 | 2.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 7.7 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 14.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.2 | 2.2 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 4.8 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.2 | 16.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 14.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.2 | 9.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 12.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 7.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 12.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 3.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 1.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 8.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 39.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.2 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.1 | 3.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 2.0 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 8.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 12.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 1.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 1.4 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 1.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 17.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 2.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 1.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 42.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.7 | 116.4 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.6 | 18.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.6 | 14.5 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.6 | 13.8 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.5 | 13.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.5 | 14.6 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.5 | 10.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 9.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.4 | 8.1 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.3 | 9.1 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.3 | 6.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 5.3 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.3 | 6.0 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.2 | 24.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 4.6 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 25.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 7.9 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.2 | 6.2 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 9.4 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.2 | 13.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 52.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 4.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 10.5 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 4.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 9.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 7.9 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 2.8 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 2.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 3.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 12.4 | REACTOME SIGNALING BY SCF KIT | Genes involved in Signaling by SCF-KIT |
| 0.1 | 3.0 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 3.2 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 3.2 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.1 | 3.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 2.0 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 5.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.0 | REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.1 | 1.4 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 3.1 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.1 | 2.1 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 2.6 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 4.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.4 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 1.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 1.3 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 1.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.7 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 0.2 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.0 | 0.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |