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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOSL2_SMARCC1

Z-value: 2.41

Motif logo

Transcription factors associated with FOSL2_SMARCC1

Gene Symbol Gene ID Gene Info
ENSG00000075426.7 FOS like 2, AP-1 transcription factor subunit
ENSG00000173473.6 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMARCC1hg19_v2_chr3_-_47823298_478234230.761.1e-04Click!
FOSL2hg19_v2_chr2_+_28615669_286157330.688.9e-04Click!

Activity profile of FOSL2_SMARCC1 motif

Sorted Z-values of FOSL2_SMARCC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL2_SMARCC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:1904303 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
2.2 11.0 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
2.2 13.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
2.1 6.3 GO:0006117 acetaldehyde metabolic process(GO:0006117)
1.6 4.7 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
1.6 29.7 GO:0051546 keratinocyte migration(GO:0051546)
1.5 9.0 GO:0098886 modification of dendritic spine(GO:0098886)
1.5 13.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
1.5 10.3 GO:1903575 cornified envelope assembly(GO:1903575)
1.4 49.3 GO:0031581 hemidesmosome assembly(GO:0031581)
1.1 3.3 GO:0035698 CD8-positive, alpha-beta T cell extravasation(GO:0035697) CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) positive regulation of necroptotic process(GO:0060545) regulation of T cell extravasation(GO:2000407) regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000449) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452)
1.1 11.7 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 3.2 GO:0048627 myoblast development(GO:0048627)
1.1 3.2 GO:1902362 melanocyte apoptotic process(GO:1902362)
1.0 4.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
1.0 25.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.9 4.7 GO:0030822 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.9 4.6 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.9 8.2 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.9 2.7 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
0.8 6.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.8 3.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.8 2.4 GO:0002384 hepatic immune response(GO:0002384)
0.8 7.9 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.8 6.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.8 6.9 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.8 3.0 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.7 2.9 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.7 3.6 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
0.7 3.9 GO:0051673 membrane disruption in other organism(GO:0051673)
0.6 3.8 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.6 6.4 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.6 4.5 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.6 1.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.6 7.9 GO:0006477 protein sulfation(GO:0006477)
0.6 8.9 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.6 3.5 GO:0060005 vestibular reflex(GO:0060005)
0.6 12.1 GO:0016540 protein autoprocessing(GO:0016540)
0.6 11.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.6 8.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.5 2.7 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.5 2.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.5 4.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.5 14.2 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.5 1.5 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.5 1.5 GO:0001922 B-1 B cell homeostasis(GO:0001922) regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
0.5 2.4 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.5 1.9 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.5 2.3 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.5 3.2 GO:0006196 AMP catabolic process(GO:0006196)
0.4 2.7 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.4 1.7 GO:0006218 uridine catabolic process(GO:0006218)
0.4 3.2 GO:0007296 vitellogenesis(GO:0007296)
0.4 1.5 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.4 4.9 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.4 2.6 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.4 10.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.4 4.3 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 1.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.3 2.4 GO:0051414 response to cortisol(GO:0051414)
0.3 2.0 GO:0044805 late nucleophagy(GO:0044805)
0.3 4.7 GO:0035092 sperm chromatin condensation(GO:0035092)
0.3 6.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3 4.2 GO:0007320 insemination(GO:0007320)
0.3 0.9 GO:0002188 translation reinitiation(GO:0002188)
0.3 2.0 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3 2.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.3 0.5 GO:0009608 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
0.3 1.1 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.3 2.8 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.3 1.0 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.2 1.2 GO:1902722 positive regulation of prolactin secretion(GO:1902722)
0.2 1.0 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.2 1.4 GO:0039019 pronephric nephron development(GO:0039019)
0.2 1.4 GO:0030421 defecation(GO:0030421)
0.2 1.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 3.7 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 1.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.3 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.2 1.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 4.1 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 6.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 0.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.2 1.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 0.6 GO:0042938 dipeptide transport(GO:0042938)
0.2 3.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 1.8 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.2 0.4 GO:1901656 glycoside transport(GO:1901656)
0.2 0.9 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 0.9 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.2 5.1 GO:0032060 bleb assembly(GO:0032060)
0.2 2.0 GO:0046449 creatinine metabolic process(GO:0046449)
0.2 0.8 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.2 1.5 GO:0051781 positive regulation of cell division(GO:0051781)
0.2 5.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2 4.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 1.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 3.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 2.0 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 1.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.8 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.4 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.1 0.6 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 4.1 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.8 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.4 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 2.4 GO:0015816 glycine transport(GO:0015816)
0.1 1.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 3.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 1.7 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.8 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 0.9 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.1 1.5 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.8 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.1 0.4 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 1.1 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.1 1.8 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.1 1.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.9 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.1 2.4 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 1.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 2.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.3 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1 0.9 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.6 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1 0.7 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.5 GO:0061502 uropod organization(GO:0032796) early endosome to recycling endosome transport(GO:0061502)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.5 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 1.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 0.9 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 0.8 GO:0032485 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.1 0.5 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.4 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 8.8 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.1 1.0 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 2.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0032960 regulation of inositol trisphosphate biosynthetic process(GO:0032960) positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.1 0.6 GO:0051012 microtubule sliding(GO:0051012)
0.1 1.6 GO:0035588 G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.1 0.1 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.1 1.7 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 1.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 5.4 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.1 GO:0007398 ectoderm development(GO:0007398)
0.1 0.6 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.1 1.3 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.1 0.2 GO:0006043 glucosamine catabolic process(GO:0006043)
0.1 1.5 GO:0001765 membrane raft assembly(GO:0001765)
0.1 1.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.4 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.5 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 2.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 1.2 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 1.0 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.1 0.7 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 1.1 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.1 1.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.9 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 12.4 GO:0016573 histone acetylation(GO:0016573)
0.0 0.3 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 2.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.2 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0033037 polysaccharide localization(GO:0033037)
0.0 0.6 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.6 GO:0040013 negative regulation of locomotion(GO:0040013)
0.0 2.4 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.5 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.9 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 0.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.6 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 1.0 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.6 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 3.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.2 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.1 GO:0034140 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.0 1.0 GO:0097186 amelogenesis(GO:0097186)
0.0 0.3 GO:0051957 positive regulation of amino acid transport(GO:0051957)
0.0 0.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 3.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.8 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.2 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.9 GO:0010842 retina layer formation(GO:0010842)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0070384 Harderian gland development(GO:0070384)
0.0 1.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.5 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 2.1 GO:0008038 neuron recognition(GO:0008038)
0.0 0.1 GO:1901053 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
0.0 0.3 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.2 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0071681 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 3.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.5 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.8 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 0.1 GO:0038178 complement component C5a signaling pathway(GO:0038178) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.6 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 3.0 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0010624 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) Schwann cell proliferation(GO:0014010)
0.0 0.6 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.6 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 1.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.5 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.9 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 3.5 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.2 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.9 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 0.1 GO:0060681 branch elongation involved in ureteric bud branching(GO:0060681)
0.0 0.7 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 1.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.1 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.0 0.1 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.2 GO:0051014 actin filament severing(GO:0051014)
0.0 2.5 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.8 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.4 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 1.5 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.9 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.3 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 1.2 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.0 0.1 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.4 GO:0045730 respiratory burst(GO:0045730)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 4.2 GO:0006457 protein folding(GO:0006457)
0.0 1.5 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.7 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.1 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 38.5 GO:0005610 laminin-5 complex(GO:0005610)
3.1 9.2 GO:0097444 spine apparatus(GO:0097444)
2.1 6.3 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
1.2 4.9 GO:0005607 laminin-2 complex(GO:0005607)
1.0 2.9 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.8 14.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.8 2.3 GO:0034515 proteasome storage granule(GO:0034515)
0.7 3.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.6 3.8 GO:0031673 H zone(GO:0031673)
0.6 3.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.6 2.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.5 1.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.5 1.8 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.4 4.0 GO:0005827 polar microtubule(GO:0005827)
0.3 2.4 GO:0033553 rDNA heterochromatin(GO:0033553)
0.3 3.3 GO:0005955 calcineurin complex(GO:0005955)
0.3 8.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 21.9 GO:0001533 cornified envelope(GO:0001533)
0.3 5.4 GO:0030056 hemidesmosome(GO:0030056)
0.3 2.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 1.2 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.2 4.2 GO:0097512 cardiac myofibril(GO:0097512)
0.2 7.9 GO:0031143 pseudopodium(GO:0031143)
0.2 0.9 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.2 1.7 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.2 1.0 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 4.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.2 4.6 GO:0005922 connexon complex(GO:0005922)
0.2 0.5 GO:0002139 stereocilia coupling link(GO:0002139)
0.1 1.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 8.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.6 GO:0031209 SCAR complex(GO:0031209)
0.1 14.2 GO:0045178 basal part of cell(GO:0045178)
0.1 5.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 5.0 GO:0031105 septin complex(GO:0031105)
0.1 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 2.0 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.4 GO:0030057 desmosome(GO:0030057)
0.1 1.4 GO:0016600 flotillin complex(GO:0016600)
0.1 1.8 GO:0032426 stereocilium tip(GO:0032426)
0.1 1.8 GO:0045179 apical cortex(GO:0045179)
0.1 2.8 GO:0036020 endolysosome membrane(GO:0036020)
0.1 4.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.8 GO:0090543 Flemming body(GO:0090543)
0.1 0.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.5 GO:0097513 myosin II filament(GO:0097513)
0.1 2.5 GO:0010369 chromocenter(GO:0010369)
0.1 0.9 GO:1990812 growth cone filopodium(GO:1990812)
0.1 0.7 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 5.5 GO:0031526 brush border membrane(GO:0031526)
0.1 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.8 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.0 GO:0030478 actin cap(GO:0030478)
0.1 8.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 3.8 GO:0016363 nuclear matrix(GO:0016363)
0.1 5.4 GO:0005902 microvillus(GO:0005902)
0.1 1.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 13.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.4 GO:1990462 omegasome(GO:1990462)
0.1 1.4 GO:0097342 ripoptosome(GO:0097342)
0.1 0.4 GO:0032010 phagolysosome(GO:0032010)
0.1 0.5 GO:0097413 Lewy body(GO:0097413)
0.1 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.4 GO:0036019 endolysosome(GO:0036019)
0.0 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 6.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0030891 VCB complex(GO:0030891)
0.0 3.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0005879 axonemal microtubule(GO:0005879)
0.0 7.9 GO:0001650 fibrillar center(GO:0001650)
0.0 1.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 1.2 GO:0032420 stereocilium(GO:0032420)
0.0 9.2 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 3.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 5.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 13.4 GO:0005769 early endosome(GO:0005769)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 7.7 GO:0030027 lamellipodium(GO:0030027)
0.0 1.1 GO:0005903 brush border(GO:0005903)
0.0 1.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 4.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.1 GO:0098858 actin-based cell projection(GO:0098858)
0.0 1.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.9 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.2 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
2.0 14.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.6 4.7 GO:0061663 NEDD8 ligase activity(GO:0061663)
1.3 5.3 GO:1990175 EH domain binding(GO:1990175)
1.2 8.3 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
1.0 4.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
1.0 13.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.9 6.3 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.8 2.4 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.7 2.7 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.6 3.6 GO:1903135 cupric ion binding(GO:1903135)
0.6 2.9 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.6 6.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.6 8.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 3.5 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.5 1.9 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.4 5.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.4 9.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 5.8 GO:0038132 neuregulin binding(GO:0038132)
0.4 2.7 GO:1990254 keratin filament binding(GO:1990254)
0.4 1.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.4 1.5 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.4 13.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 1.7 GO:0004850 uridine phosphorylase activity(GO:0004850)
0.3 1.0 GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086040)
0.3 3.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.3 3.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 6.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 6.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 1.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.3 0.9 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.3 0.3 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.3 1.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 44.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 4.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 5.1 GO:0019841 retinol binding(GO:0019841)
0.3 1.9 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 4.7 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 2.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.3 1.5 GO:0070026 nitric oxide binding(GO:0070026)
0.2 3.9 GO:0042834 peptidoglycan binding(GO:0042834)
0.2 1.2 GO:0003867 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.2 1.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.2 3.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 1.2 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 1.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 3.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 0.8 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.2 7.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 4.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 4.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 0.5 GO:0070984 SET domain binding(GO:0070984)
0.2 3.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 1.0 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 1.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.8 GO:0050544 arachidonic acid binding(GO:0050544)
0.2 0.5 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.2 0.9 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 3.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 4.1 GO:0044548 S100 protein binding(GO:0044548)
0.1 1.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.6 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.7 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 11.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 18.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.6 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.1 1.4 GO:0004969 histamine receptor activity(GO:0004969)
0.1 1.5 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.1 5.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.5 GO:0003883 CTP synthase activity(GO:0003883)
0.1 2.4 GO:0001164 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 1.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.6 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.1 1.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 1.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.3 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 1.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 3.4 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 22.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 18.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.1 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.0 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.2 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.1 0.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 1.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 3.7 GO:0030332 cyclin binding(GO:0030332)
0.1 1.8 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.3 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.4 GO:0043022 ribosome binding(GO:0043022)
0.1 0.2 GO:0031862 prostanoid receptor binding(GO:0031862)
0.1 9.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.5 GO:0004359 glutaminase activity(GO:0004359)
0.1 1.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 2.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.8 GO:0003774 motor activity(GO:0003774)
0.1 1.1 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 1.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.6 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.9 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 1.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 3.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.0 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 1.0 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.2 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0008480 sarcosine dehydrogenase activity(GO:0008480)
0.0 0.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 1.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.4 GO:0048156 tau protein binding(GO:0048156)
0.0 2.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.7 GO:0004175 endopeptidase activity(GO:0004175)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 5.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0019959 interleukin-8 receptor activity(GO:0004918) interleukin-8 binding(GO:0019959)
0.0 0.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.7 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.3 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.0 GO:0003676 nucleic acid binding(GO:0003676)
0.0 1.3 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.6 GO:0008009 chemokine activity(GO:0008009)
0.0 1.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 3.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.2 GO:0004568 chitinase activity(GO:0004568)
0.0 0.5 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 1.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.7 GO:0050699 WW domain binding(GO:0050699)
0.0 6.6 GO:0003779 actin binding(GO:0003779)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 48.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 25.4 PID IL1 PATHWAY IL1-mediated signaling events
0.2 4.7 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.2 13.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 1.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 15.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.1 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 7.0 PID ENDOTHELIN PATHWAY Endothelins
0.1 6.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 6.9 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.2 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 3.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.8 ST STAT3 PATHWAY STAT3 Pathway
0.1 8.7 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 4.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 3.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 4.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.4 PID ARF 3PATHWAY Arf1 pathway
0.0 2.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 3.4 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 6.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.9 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 2.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 6.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.2 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 8.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.4 6.3 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.3 57.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.3 7.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 18.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.2 4.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 3.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 8.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 5.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 4.0 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 3.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.1 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 3.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.8 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 7.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.7 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.0 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 4.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 3.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 7.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 1.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.6 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.3 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.1 2.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 2.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 4.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 3.7 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 1.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.8 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.1 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 2.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 3.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis