ISMARA results: FOXA2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXA2_FOXJ3

Z-value: 0.54

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Transcription factors associated with FOXA2_FOXJ3

Gene Symbol	Gene ID	Gene Info
FOXA2 Ensembl NCBI GeneCards UniProt	ENSG00000125798.10	forkhead box A2
FOXJ3 Ensembl NCBI GeneCards UniProt	ENSG00000198815.4	forkhead box J3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXA2	hg19_v2_chr20_-_22565101_22565223	0.10	6.6e-01	Click!
FOXJ3	hg19_v2_chr1_-_42800860_42800912	0.09	7.2e-01	Click!

Activity profile of FOXA2_FOXJ3 motif

Sorted Z-values of FOXA2_FOXJ3 motif

No targets for FOXA2_FOXJ3

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA2_FOXJ3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
0.0	0.6	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.6	GO:1901898	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	0.6	GO:0034501	protein localization to kinetochore(GO:0034501)
0.2	0.5	GO:0033364	mast cell secretory granule organization(GO:0033364)
0.1	0.5	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.5	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.5	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.5	GO:1904776	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0	0.5	GO:1902751	positive regulation of cell cycle G2/M phase transition(GO:1902751)

Showing 1 to 10 of 89 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.7	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.6	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.5	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.5	GO:0008091	spectrin(GO:0008091)
0.1	0.4	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0	0.4	GO:0042588	zymogen granule(GO:0042588)
0.0	0.4	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.4	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1	0.3	GO:1902636	kinociliary basal body(GO:1902636)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.1	0.6	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.6	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.0	0.6	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	0.5	GO:0016402	pristanoyl-CoA oxidase activity(GO:0016402)
0.1	0.5	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.4	GO:0102337	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.4	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.3	GO:0002046	opsin binding(GO:0002046)
0.1	0.3	GO:0044378	non-sequence-specific DNA binding, bending(GO:0044378)

Showing 1 to 10 of 60 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.7	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.6	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.4	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.4	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.3	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism

Showing 1 to 10 of 13 entries

Results for FOXA2_FOXJ3

Z-value: 0.54

Motif logo

Transcription factors associated with FOXA2_FOXJ3

Activity-expression correlation:

Activity profile of FOXA2_FOXJ3 motif

Sorted Z-values of FOXA2_FOXJ3 motif

No targets for FOXA2_FOXJ3

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA2_FOXJ3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: