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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXA2_FOXJ3

Z-value: 0.54

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Transcription factors associated with FOXA2_FOXJ3

Gene Symbol Gene ID Gene Info
ENSG00000125798.10 forkhead box A2
ENSG00000198815.4 forkhead box J3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXA2hg19_v2_chr20_-_22565101_225652230.106.6e-01Click!
FOXJ3hg19_v2_chr1_-_42800860_428009120.097.2e-01Click!

Activity profile of FOXA2_FOXJ3 motif

Sorted Z-values of FOXA2_FOXJ3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA2_FOXJ3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.4 GO:0051685 maintenance of ER location(GO:0051685)
0.1 0.3 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 0.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.3 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.2 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.2 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.1 0.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.6 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.4 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.5 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.6 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.2 GO:0034505 tooth mineralization(GO:0034505) enamel mineralization(GO:0070166)
0.0 0.2 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.3 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.4 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.1 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.1 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.1 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.1 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.2 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.2 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0 0.2 GO:2001151 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.0 0.1 GO:2000627 rRNA import into mitochondrion(GO:0035928) regulation of miRNA catabolic process(GO:2000625) positive regulation of miRNA catabolic process(GO:2000627)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.2 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0 0.5 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0090309 maintenance of DNA methylation(GO:0010216) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.1 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.5 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0030806 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:0002316 follicular B cell differentiation(GO:0002316)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.0 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.1 GO:1902510 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.8 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.0 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.4 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.5 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.5 GO:0000732 strand displacement(GO:0000732)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.3 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.1 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:1902741 interferon-alpha secretion(GO:0072642) telomerase RNA stabilization(GO:0090669) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.0 0.1 GO:0042126 nitrate metabolic process(GO:0042126)
0.0 0.1 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1902636 kinociliary basal body(GO:1902636)
0.1 0.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.4 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.3 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0005712 chiasma(GO:0005712)
0.0 0.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.5 GO:0008091 spectrin(GO:0008091)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.4 GO:0042588 zymogen granule(GO:0042588)
0.0 0.0 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.0 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.1 0.2 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.3 GO:0002046 opsin binding(GO:0002046)
0.1 0.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.1 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.1 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.0 0.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.4 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.1 GO:0004397 histidine ammonia-lyase activity(GO:0004397)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.1 GO:0004905 type I interferon receptor activity(GO:0004905)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0008940 nitrate reductase activity(GO:0008940)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.4 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events