ISMARA results: FOXA3

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXA3_FOXC2

Z-value: 1.04

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Transcription factors associated with FOXA3_FOXC2

Gene Symbol	Gene ID	Gene Info
FOXA3 Ensembl NCBI GeneCards UniProt	ENSG00000170608.2	forkhead box A3
FOXC2 Ensembl NCBI GeneCards UniProt	ENSG00000176692.4	forkhead box C2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXA3	hg19_v2_chr19_+_46367518_46367567	0.77	7.3e-05	Click!
FOXC2	hg19_v2_chr16_+_86600857_86600921	0.69	7.5e-04	Click!

Activity profile of FOXA3_FOXC2 motif

Sorted Z-values of FOXA3_FOXC2 motif

No targets for FOXA3_FOXC2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA3_FOXC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.6	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.4	2.4	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1	2.4	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.5	2.3	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.1	2.3	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	1.9	GO:0008045	motor neuron axon guidance(GO:0008045)
0.6	1.7	GO:0033364	mast cell secretory granule organization(GO:0033364)
0.4	1.7	GO:0044537	regulation of circulating fibrinogen levels(GO:0044537)
0.0	1.7	GO:0046324	regulation of glucose import(GO:0046324)
0.3	1.6	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)

Showing 1 to 10 of 111 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0005916	fascia adherens(GO:0005916) catenin complex(GO:0016342)
0.6	2.4	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	2.4	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	2.4	GO:0031225	anchored component of membrane(GO:0031225)
0.0	2.3	GO:0005905	clathrin-coated pit(GO:0005905)
0.0	2.0	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1	1.9	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	1.9	GO:0042588	zymogen granule(GO:0042588)
0.1	1.5	GO:0032982	myosin filament(GO:0032982)
0.0	1.4	GO:0005876	spindle microtubule(GO:0005876)

Showing 1 to 10 of 39 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.1	2.7	GO:0045294	alpha-catenin binding(GO:0045294) gamma-catenin binding(GO:0045295)
0.1	2.5	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3	2.4	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.8	2.3	GO:0031859	platelet activating factor receptor binding(GO:0031859)
0.3	2.3	GO:0016167	glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0	1.6	GO:0005518	collagen binding(GO:0005518)
0.3	1.4	GO:0044378	non-sequence-specific DNA binding, bending(GO:0044378)
0.1	1.4	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.2	1.3	GO:0015350	methotrexate transporter activity(GO:0015350)

Showing 1 to 10 of 66 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	2.7	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	2.4	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	2.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.8	PID ATM PATHWAY	ATM pathway
0.0	1.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.3	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	1.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	1.1	PID RAC1 PATHWAY	RAC1 signaling pathway

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	2.4	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	2.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	2.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	2.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	1.8	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	1.7	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	1.7	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	1.6	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	1.5	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling

Showing 1 to 10 of 30 entries

Results for FOXA3_FOXC2

Z-value: 1.04

Motif logo

Transcription factors associated with FOXA3_FOXC2

Activity-expression correlation:

Activity profile of FOXA3_FOXC2 motif

Sorted Z-values of FOXA3_FOXC2 motif

No targets for FOXA3_FOXC2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXA3_FOXC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: