ISMARA results: FOXC1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXC1

Z-value: 0.94

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Transcription factors associated with FOXC1

Gene Symbol	Gene ID	Gene Info
FOXC1 Ensembl NCBI GeneCards UniProt	ENSG00000054598.5	forkhead box C1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXC1	hg19_v2_chr6_+_1610681_1610681	0.46	4.4e-02	Click!

Activity profile of FOXC1 motif

Sorted Z-values of FOXC1 motif

No targets for FOXC1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.5	GO:0038044	transforming growth factor-beta secretion(GO:0038044)
1.1	4.5	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.2	2.7	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.4	2.5	GO:0060005	vestibular reflex(GO:0060005)
0.1	2.4	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.7	2.2	GO:1904761	negative regulation of myofibroblast differentiation(GO:1904761)
0.0	2.1	GO:0010107	potassium ion import(GO:0010107)
0.5	2.0	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.0	2.0	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.2	1.7	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)

Showing 1 to 10 of 100 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	5.5	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.5	4.5	GO:0005955	calcineurin complex(GO:0005955)
0.2	2.4	GO:0042587	glycogen granule(GO:0042587)
0.0	2.1	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	2.0	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	1.7	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	1.5	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.1	1.4	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.2	1.2	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.1	1.2	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)

Showing 1 to 10 of 34 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.4	GO:0001618	virus receptor activity(GO:0001618)
0.3	4.5	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	2.7	GO:0043015	gamma-tubulin binding(GO:0043015)
0.5	2.4	GO:0050115	myosin-light-chain-phosphatase activity(GO:0050115)
0.1	2.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	2.0	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.6	1.7	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.1	1.4	GO:0089720	caspase binding(GO:0089720)
0.0	1.3	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	1.2	GO:0070016	gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)

Showing 1 to 10 of 62 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	4.5	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	3.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	2.4	PID PLK1 PATHWAY	PLK1 signaling events
0.0	2.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.1	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	1.5	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	1.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.2	PID AP1 PATHWAY	AP-1 transcription factor network

Showing 1 to 10 of 22 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	3.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	2.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	2.1	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	1.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	1.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.2	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.0	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.8	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.7	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1

Showing 1 to 10 of 23 entries

Results for FOXC1

Z-value: 0.94

Motif logo

Transcription factors associated with FOXC1

Activity-expression correlation:

Activity profile of FOXC1 motif

Sorted Z-values of FOXC1 motif

No targets for FOXC1

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: