ISMARA results: FOXK1_FOXP2_FOXB1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXK1_FOXP2_FOXB1_FOXP3

Z-value: 1.21

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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3

Gene Symbol	Gene ID	Gene Info
FOXK1 Ensembl NCBI GeneCards UniProt	ENSG00000164916.9	forkhead box K1
FOXP2 Ensembl NCBI GeneCards UniProt	ENSG00000128573.18	forkhead box P2
FOXB1 Ensembl NCBI GeneCards UniProt	ENSG00000171956.5	forkhead box B1
FOXP3 Ensembl NCBI GeneCards UniProt	ENSG00000049768.10	forkhead box P3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXP2	hg19_v2_chr7_+_114055052_114055378	-0.31	1.8e-01	Click!
FOXB1	hg19_v2_chr15_+_60296421_60296464	0.21	3.6e-01	Click!
FOXP3	hg19_v2_chrX_-_49121165_49121288	0.05	8.4e-01	Click!
FOXK1	hg19_v2_chr7_+_4721885_4721945	-0.04	8.7e-01	Click!

Activity profile of FOXK1_FOXP2_FOXB1_FOXP3 motif

Sorted Z-values of FOXK1_FOXP2_FOXB1_FOXP3 motif

No targets for FOXK1_FOXP2_FOXB1_FOXP3

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	9.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.3	5.2	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	4.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1	4.5	GO:1990926	short-term synaptic potentiation(GO:1990926)
0.3	4.4	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.6	4.2	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.4	3.9	GO:1990822	basic amino acid transmembrane transport(GO:1990822)
0.0	3.9	GO:2000257	regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.1	3.8	GO:0090383	phagosome acidification(GO:0090383)
0.2	3.6	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)

Showing 1 to 10 of 481 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.7	GO:0072562	blood microparticle(GO:0072562)
0.3	5.2	GO:0031089	platelet dense granule lumen(GO:0031089)
0.4	5.0	GO:0005577	fibrinogen complex(GO:0005577)
0.6	4.5	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	4.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	3.9	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	3.9	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	3.9	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1	3.6	GO:0005915	zonula adherens(GO:0005915)
1.1	3.4	GO:1902636	kinociliary basal body(GO:1902636)

Showing 1 to 10 of 168 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	GO:0017075	syntaxin-1 binding(GO:0017075)
1.0	5.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	4.9	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2	3.9	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	3.8	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0	3.8	GO:0015078	hydrogen ion transmembrane transporter activity(GO:0015078)
0.2	3.5	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.8	3.4	GO:0004967	glucagon receptor activity(GO:0004967)
0.7	3.4	GO:0002046	opsin binding(GO:0002046)
0.1	3.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)

Showing 1 to 10 of 304 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	5.1	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	4.8	PID BMP PATHWAY	BMP receptor signaling
0.0	4.0	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	3.8	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	3.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	2.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	2.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	2.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 58 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.1	7.6	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	7.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	5.9	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.3	5.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	5.5	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.1	5.5	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	4.9	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	4.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	4.6	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)

Showing 1 to 10 of 86 entries

Results for FOXK1_FOXP2_FOXB1_FOXP3

Z-value: 1.21

Motif logo

Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3

Activity-expression correlation:

Activity profile of FOXK1_FOXP2_FOXB1_FOXP3 motif

Sorted Z-values of FOXK1_FOXP2_FOXB1_FOXP3 motif

No targets for FOXK1_FOXP2_FOXB1_FOXP3

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: