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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXQ1

Z-value: 1.47

Motif logo

Transcription factors associated with FOXQ1

Gene Symbol Gene ID Gene Info
ENSG00000164379.4 forkhead box Q1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXQ1hg19_v2_chr6_+_1312675_13127010.106.8e-01Click!

Activity profile of FOXQ1 motif

Sorted Z-values of FOXQ1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXQ1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 7.2 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
1.3 3.9 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.2 4.8 GO:0006542 glutamine biosynthetic process(GO:0006542)
1.0 3.0 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.9 2.7 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.4 2.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.4 1.3 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.3 1.0 GO:0008057 eye pigment granule organization(GO:0008057)
0.3 1.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.3 6.4 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.3 0.8 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.3 0.8 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.2 1.4 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.2 0.8 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 1.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 0.9 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.2 0.5 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.2 0.7 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.2 0.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 1.0 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.2 0.9 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.7 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.1 0.6 GO:0046110 xanthine metabolic process(GO:0046110)
0.1 0.5 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.1 1.9 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1 0.8 GO:0018032 protein amidation(GO:0018032)
0.1 0.9 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1 0.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.6 GO:0060437 lung growth(GO:0060437)
0.1 0.5 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 1.7 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.3 GO:1990637 response to prolactin(GO:1990637)
0.1 1.3 GO:0015074 DNA integration(GO:0015074)
0.1 0.4 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 1.7 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.1 1.5 GO:0051451 myoblast migration(GO:0051451)
0.1 1.0 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1 0.8 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 1.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 0.3 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.1 0.4 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.1 0.9 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.1 1.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.2 GO:0060988 lipid tube assembly(GO:0060988)
0.1 1.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.3 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.7 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.5 GO:1902714 antifungal humoral response(GO:0019732) negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.4 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.4 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1 1.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 0.4 GO:0016139 glycoside catabolic process(GO:0016139)
0.1 0.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.4 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.1 0.3 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 0.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.3 GO:0006311 meiotic gene conversion(GO:0006311) male meiosis chromosome segregation(GO:0007060)
0.1 0.3 GO:0070343 white fat cell proliferation(GO:0070343) positive regulation of fat cell proliferation(GO:0070346) regulation of white fat cell proliferation(GO:0070350)
0.1 0.3 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.3 GO:0015692 lead ion transport(GO:0015692)
0.0 0.4 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 2.3 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.0 0.1 GO:1903217 regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.0 0.4 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.0 0.7 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 1.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 3.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0043132 NAD transport(GO:0043132)
0.0 0.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.0 0.2 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 2.5 GO:1901998 toxin transport(GO:1901998)
0.0 0.3 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.6 GO:0097475 motor neuron migration(GO:0097475)
0.0 1.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.7 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.6 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.1 GO:0015881 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.0 0.2 GO:0072093 ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.0 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.9 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.4 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0006196 AMP catabolic process(GO:0006196)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.2 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.6 GO:0045008 depyrimidination(GO:0045008)
0.0 0.1 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.3 GO:0007632 visual behavior(GO:0007632)
0.0 0.2 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 0.8 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.7 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0 2.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.6 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0030238 male sex determination(GO:0030238)
0.0 0.4 GO:0048680 positive regulation of axon regeneration(GO:0048680)
0.0 3.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.7 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 1.4 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0042214 terpene metabolic process(GO:0042214)
0.0 0.9 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995) oxygen metabolic process(GO:0072592)
0.0 0.6 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 1.1 GO:0035115 embryonic forelimb morphogenesis(GO:0035115)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 1.0 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0 0.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 1.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.3 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.2 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 1.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 4.0 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.1 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.3 GO:2000111 regulation of macrophage apoptotic process(GO:2000109) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.3 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.0 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 1.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.6 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.4 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.8 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.2 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0046449 creatinine metabolic process(GO:0046449)
0.0 0.1 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 1.0 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.0 0.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0070307 lens fiber cell development(GO:0070307)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 4.4 GO:0097386 glial cell projection(GO:0097386)
0.1 1.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 2.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 1.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.5 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.1 GO:0070470 plasma membrane respiratory chain(GO:0070470)
0.1 1.0 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.3 GO:0031592 centrosomal corona(GO:0031592)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.8 GO:0043219 lateral loop(GO:0043219)
0.1 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 4.0 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.3 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.4 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 1.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0002177 manchette(GO:0002177)
0.0 0.4 GO:0033263 CORVET complex(GO:0033263)
0.0 0.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 7.5 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.5 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.4 GO:0001939 female pronucleus(GO:0001939)
0.0 0.3 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 1.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.1 GO:0015030 Cajal body(GO:0015030)
0.0 1.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 6.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.0 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.8 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 1.4 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.3 1.0 GO:0033149 FFAT motif binding(GO:0033149)
0.3 1.0 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.3 1.5 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 1.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.3 1.3 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.3 0.8 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.2 0.7 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 0.7 GO:0035643 L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544)
0.2 1.7 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.2 1.0 GO:0004556 alpha-amylase activity(GO:0004556)
0.2 0.9 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.2 0.5 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.2 4.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.4 GO:0015928 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 1.0 GO:0050733 RS domain binding(GO:0050733)
0.1 0.6 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.1 0.8 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.6 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.5 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.1 0.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.8 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 0.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.4 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.4 GO:0016295 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.1 0.3 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 0.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.4 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.5 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 1.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 0.4 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.5 GO:0030172 troponin C binding(GO:0030172)
0.1 1.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.3 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 6.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.5 GO:0089720 caspase binding(GO:0089720)
0.1 0.8 GO:0097016 L27 domain binding(GO:0097016)
0.1 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 1.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.2 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 1.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 3.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.2 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.4 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.2 GO:0031005 filamin binding(GO:0031005)
0.0 1.5 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 6.8 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.7 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 2.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.2 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0047946 glutamine N-acyltransferase activity(GO:0047946)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 5.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0055103 ligase regulator activity(GO:0055103)
0.0 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.1 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 4.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.5 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 1.1 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.0 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.2 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.5 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.5 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.0 PID ALK1 PATHWAY ALK1 signaling events
0.1 5.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 12.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.3 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 2.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 2.2 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 2.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 4.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.8 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 1.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.8 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 2.1 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.8 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.6 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 3.0 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 1.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.6 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.1 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 1.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha