ISMARA results: GATA1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GATA1_GATA4

Z-value: 1.29

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Transcription factors associated with GATA1_GATA4

Gene Symbol	Gene ID	Gene Info
GATA1 Ensembl NCBI GeneCards UniProt	ENSG00000102145.9	GATA binding protein 1
GATA4 Ensembl NCBI GeneCards UniProt	ENSG00000136574.13	GATA binding protein 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA4	hg19_v2_chr8_+_11534462_11534475	-0.84	4.1e-06	Click!
GATA1	hg19_v2_chrX_+_48644962_48644983	0.05	8.4e-01	Click!

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

No targets for GATA1_GATA4

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.2	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.6	6.6	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.8	5.3	GO:0002786	regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.1	4.2	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
1.0	3.9	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.0	3.4	GO:0009301	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.8	3.3	GO:0071894	histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1	3.1	GO:0032731	positive regulation of interleukin-1 beta production(GO:0032731)
0.0	3.0	GO:0018149	peptide cross-linking(GO:0018149)
0.1	2.8	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)

Showing 1 to 10 of 231 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.8	GO:0097228	sperm principal piece(GO:0097228)
0.8	5.3	GO:0097209	epidermal lamellar body(GO:0097209)
0.0	5.1	GO:0005604	basement membrane(GO:0005604)
0.1	3.9	GO:0001533	cornified envelope(GO:0001533)
0.0	3.5	GO:0005913	cell-cell adherens junction(GO:0005913)
0.4	3.4	GO:0070876	SOSS complex(GO:0070876)
0.0	3.3	GO:0005681	spliceosomal complex(GO:0005681)
0.0	2.7	GO:0002102	podosome(GO:0002102)
0.0	2.6	GO:0016605	PML body(GO:0016605)
0.2	2.2	GO:0005610	laminin-5 complex(GO:0005610)

Showing 1 to 10 of 88 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	12.1	GO:0045296	cadherin binding(GO:0045296)
0.5	9.9	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	9.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.7	6.4	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	5.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	3.9	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.1	3.9	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	3.6	GO:0003697	single-stranded DNA binding(GO:0003697)
0.1	3.4	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1	3.3	GO:0000993	RNA polymerase II core binding(GO:0000993)

Showing 1 to 10 of 139 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	3.0	PID P73PATHWAY	p73 transcription factor network
0.0	2.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	2.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	2.1	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	2.0	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	1.8	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	1.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.4	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway

Showing 1 to 10 of 24 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.4	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	3.0	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	2.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	2.4	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	2.0	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	1.9	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	1.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	1.9	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	1.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	1.7	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis

Showing 1 to 10 of 45 entries

Results for GATA1_GATA4

Z-value: 1.29

Motif logo

Transcription factors associated with GATA1_GATA4

Activity-expression correlation:

Activity profile of GATA1_GATA4 motif

Sorted Z-values of GATA1_GATA4 motif

No targets for GATA1_GATA4

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA1_GATA4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: