ISMARA results: GATA6

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GATA6

Z-value: 0.97

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Transcription factors associated with GATA6

Gene Symbol	Gene ID	Gene Info
GATA6 Ensembl NCBI GeneCards UniProt	ENSG00000141448.4	GATA binding protein 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GATA6	hg19_v2_chr18_+_19750894_19750980	-0.56	1.1e-02	Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

No targets for GATA6

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	3.6	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.5	2.7	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.2	2.3	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.5	2.1	GO:0060585	nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1	2.0	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2	1.7	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	1.6	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	1.6	GO:0007405	neuroblast proliferation(GO:0007405)
0.2	1.2	GO:0098707	ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.2	1.1	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)

Showing 1 to 10 of 47 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.1	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.1	2.0	GO:0043194	axon initial segment(GO:0043194)
0.1	1.6	GO:1990023	mitotic spindle midzone(GO:1990023)
0.1	1.2	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.9	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.8	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2	0.7	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.7	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.6	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1	0.5	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)

Showing 1 to 10 of 20 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.6	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	2.7	GO:0003680	AT DNA binding(GO:0003680)
0.0	2.3	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.4	2.1	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	2.0	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	1.7	GO:0005504	fatty acid binding(GO:0005504)
0.0	1.7	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3	1.2	GO:0004998	transferrin receptor activity(GO:0004998)
0.0	1.1	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	1.0	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)

Showing 1 to 10 of 36 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.1	PID ENDOTHELIN PATHWAY	Endothelins
1.8	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
1.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
1.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.7	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 6 of 6 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	2.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	2.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	1.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	1.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.4	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	1.0	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.8	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.7	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.6	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)

Showing 1 to 10 of 14 entries

Results for GATA6

Z-value: 0.97

Motif logo

Transcription factors associated with GATA6

Activity-expression correlation:

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

No targets for GATA6

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: