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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GCM1

Z-value: 0.89

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Transcription factors associated with GCM1

Gene Symbol Gene ID Gene Info
ENSG00000137270.10 glial cells missing transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM1hg19_v2_chr6_-_53013620_53013644-0.077.8e-01Click!

Activity profile of GCM1 motif

Sorted Z-values of GCM1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0048627 myoblast development(GO:0048627)
0.4 2.5 GO:0042335 cuticle development(GO:0042335)
0.3 1.6 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.3 1.2 GO:1902910 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.3 1.2 GO:0006566 threonine metabolic process(GO:0006566)
0.3 0.9 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.3 0.8 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.2 2.0 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 0.9 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.2 1.4 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 1.4 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.2 1.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 0.8 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 5.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.9 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.4 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.1 1.2 GO:2000252 negative regulation of feeding behavior(GO:2000252)
0.1 0.6 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 0.3 GO:0032242 regulation of nucleoside transport(GO:0032242) positive regulation of necroptotic process(GO:0060545)
0.1 0.5 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.6 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.6 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
0.1 0.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 0.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.6 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 1.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.2 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.1 0.8 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.1 0.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.4 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.3 GO:0016240 autophagosome docking(GO:0016240)
0.1 0.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.3 GO:1902728 mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.1 0.7 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.0 0.5 GO:1902365 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.2 GO:2001170 positive regulation of fat cell proliferation(GO:0070346) negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.2 GO:1990736 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.0 0.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.4 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.1 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.0 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 1.0 GO:0007614 short-term memory(GO:0007614)
0.0 0.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.2 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.2 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.4 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.3 GO:0042256 mature ribosome assembly(GO:0042256) positive regulation of mitochondrial translation(GO:0070131)
0.0 0.1 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.5 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.3 GO:0046618 drug export(GO:0046618)
0.0 0.2 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0010193 response to ozone(GO:0010193) response to L-ascorbic acid(GO:0033591)
0.0 0.0 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.0 0.1 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 0.4 GO:0042574 retinal metabolic process(GO:0042574)
0.0 1.3 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.7 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.3 GO:0072321 protein import into peroxisome membrane(GO:0045046) chaperone-mediated protein transport(GO:0072321)
0.0 0.2 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 0.2 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 1.2 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.8 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191) vesicle uncoating(GO:0072319)
0.0 0.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
0.0 0.1 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.0 0.2 GO:0032418 lysosome localization(GO:0032418)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.6 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.9 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.1 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.6 GO:0031673 H zone(GO:0031673)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.2 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.1 2.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.5 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.8 GO:0032059 bleb(GO:0032059)
0.0 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.2 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.5 GO:0033391 chromatoid body(GO:0033391)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.4 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.9 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.4 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0097342 ripoptosome(GO:0097342)
0.0 0.2 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.0 0.0 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0036019 endolysosome(GO:0036019)
0.0 1.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.7 GO:0005795 Golgi stack(GO:0005795)
0.0 0.4 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.4 1.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.3 1.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.3 0.8 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 0.6 GO:0002113 interleukin-33 binding(GO:0002113)
0.2 2.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.6 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 0.6 GO:1990175 EH domain binding(GO:1990175)
0.1 0.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 1.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.3 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 0.3 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 0.7 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.6 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.2 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.3 GO:0016295 oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.2 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
0.0 1.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.9 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.9 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0 0.3 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.3 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.2 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 1.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 1.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.0 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 6.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.6 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 1.5 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.9 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling