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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GCM2

Z-value: 2.64

Motif logo

Transcription factors associated with GCM2

Gene Symbol Gene ID Gene Info
ENSG00000124827.6 glial cells missing transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GCM2hg19_v2_chr6_-_10882174_108822740.126.0e-01Click!

Activity profile of GCM2 motif

Sorted Z-values of GCM2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
1.4 5.5 GO:0006601 creatine biosynthetic process(GO:0006601)
1.0 4.2 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.8 4.7 GO:1903412 response to bile acid(GO:1903412)
0.8 2.3 GO:0072034 renal vesicle induction(GO:0072034)
0.7 2.0 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.7 2.6 GO:0023016 osmosensory signaling pathway(GO:0007231) signal transduction by trans-phosphorylation(GO:0023016) kidney smooth muscle tissue development(GO:0072194) pattern specification involved in metanephros development(GO:0072268)
0.6 3.2 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.6 1.9 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.6 3.9 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.6 2.8 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.6 1.7 GO:0060796 regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796)
0.6 2.2 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
0.5 1.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.5 2.1 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.5 5.2 GO:0046078 dUMP metabolic process(GO:0046078)
0.5 1.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.4 4.9 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.4 3.7 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.4 1.6 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.4 4.6 GO:0071321 cellular response to cGMP(GO:0071321)
0.4 1.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.3 2.1 GO:0086021 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021)
0.3 1.0 GO:0045720 negative regulation of integrin biosynthetic process(GO:0045720)
0.3 3.4 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.3 5.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.3 0.9 GO:0034552 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.3 3.1 GO:0060263 regulation of respiratory burst(GO:0060263)
0.3 7.2 GO:0031167 rRNA methylation(GO:0031167)
0.3 0.8 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.3 0.8 GO:0006173 dADP biosynthetic process(GO:0006173)
0.3 1.0 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.2 1.0 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.2 0.7 GO:0006481 C-terminal protein methylation(GO:0006481)
0.2 3.4 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.2 5.8 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.2 1.0 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.2 0.6 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 0.4 GO:0071661 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.2 0.7 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.2 0.5 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
0.2 1.2 GO:0015798 myo-inositol transport(GO:0015798)
0.2 5.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 2.7 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.2 3.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 0.4 GO:1904875 regulation of DNA ligase activity(GO:1904875)
0.1 0.9 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 3.7 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 3.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.4 GO:0007538 primary sex determination(GO:0007538)
0.1 1.8 GO:0035092 sperm chromatin condensation(GO:0035092)
0.1 0.4 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 0.4 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976)
0.1 2.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.0 GO:0060501 negative regulation of keratinocyte differentiation(GO:0045617) positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 0.7 GO:1902731 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.1 1.0 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.6 GO:0021997 neural plate axis specification(GO:0021997)
0.1 1.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 1.0 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.4 GO:0009386 translational attenuation(GO:0009386)
0.1 0.7 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 1.0 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 0.5 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 1.0 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 3.3 GO:0097284 hepatocyte apoptotic process(GO:0097284)
0.1 0.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.8 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 1.8 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 0.3 GO:0044691 tooth eruption(GO:0044691)
0.1 1.6 GO:0006554 lysine catabolic process(GO:0006554)
0.1 1.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 1.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.5 GO:0071105 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340) response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.1 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.3 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 1.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 0.9 GO:0002829 negative regulation of type 2 immune response(GO:0002829) regulation of isotype switching to IgG isotypes(GO:0048302)
0.1 0.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 2.2 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 1.7 GO:0002021 response to dietary excess(GO:0002021)
0.1 2.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 1.0 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.6 GO:0006538 glutamate biosynthetic process(GO:0006537) glutamate catabolic process(GO:0006538)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 2.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 1.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.3 GO:0060174 limb bud formation(GO:0060174)
0.0 0.5 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.3 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.5 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.3 GO:0003072 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 3.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.3 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.9 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 2.4 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.0 1.8 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)
0.0 0.3 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.7 GO:0034605 cellular response to heat(GO:0034605)
0.0 3.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.8 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 1.4 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 1.9 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.4 GO:0015824 proline transport(GO:0015824)
0.0 0.3 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 1.2 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.0 4.4 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 2.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.3 GO:0014041 regulation of neuron maturation(GO:0014041)
0.0 1.0 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 2.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 0.4 GO:1901620 regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0 0.4 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 1.4 GO:0001881 receptor recycling(GO:0001881)
0.0 0.9 GO:0014002 astrocyte development(GO:0014002)
0.0 1.6 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.0 2.7 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.2 GO:0010043 response to zinc ion(GO:0010043)
0.0 11.1 GO:0042493 response to drug(GO:0042493)
0.0 0.5 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.0 0.4 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.1 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 2.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.8 GO:0043401 steroid hormone mediated signaling pathway(GO:0043401)
0.0 0.4 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 2.1 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.2 GO:0060539 diaphragm development(GO:0060539)
0.0 1.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.7 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0098855 HCN channel complex(GO:0098855)
0.7 5.4 GO:1990393 3M complex(GO:1990393)
0.5 2.7 GO:0009368 endopeptidase Clp complex(GO:0009368)
0.4 3.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 3.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.3 1.0 GO:0097124 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.3 2.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.2 0.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.2 1.4 GO:0070852 cell body fiber(GO:0070852)
0.2 3.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.7 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.0 GO:0005638 lamin filament(GO:0005638)
0.1 1.8 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 5.2 GO:0009925 basal plasma membrane(GO:0009925)
0.1 3.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.1 GO:0005922 connexon complex(GO:0005922)
0.1 1.1 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.2 GO:0010369 chromocenter(GO:0010369)
0.1 1.0 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 3.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 2.1 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 3.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.4 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.0 5.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.9 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.5 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 11.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 1.0 GO:0005686 U2 snRNP(GO:0005686)
0.0 2.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.6 GO:0042629 mast cell granule(GO:0042629)
0.0 2.0 GO:0097546 ciliary base(GO:0097546)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 2.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.0 GO:0030133 transport vesicle(GO:0030133)
0.0 0.8 GO:0043679 axon terminus(GO:0043679)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0015067 amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
1.7 5.2 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
1.2 7.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.9 4.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.8 3.8 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.6 3.7 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 2.3 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.4 3.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.4 15.9 GO:0070410 co-SMAD binding(GO:0070410)
0.4 4.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.4 3.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.4 3.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.4 5.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.4 1.9 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.3 2.1 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.3 1.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505) 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.3 3.8 GO:0004969 histamine receptor activity(GO:0004969)
0.3 2.8 GO:0032810 sterol response element binding(GO:0032810)
0.3 1.5 GO:0031208 POZ domain binding(GO:0031208)
0.3 1.7 GO:0003998 acylphosphatase activity(GO:0003998)
0.3 4.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.3 0.8 GO:0097689 iron channel activity(GO:0097689)
0.3 2.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.2 1.0 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.2 1.0 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.7 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.2 5.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.2 5.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.2 0.5 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
0.2 3.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 3.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 1.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 1.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 3.2 GO:0019841 retinal binding(GO:0016918) retinol binding(GO:0019841)
0.1 0.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.6 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.1 0.8 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.9 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.6 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 4.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.1 0.4 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 0.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.1 1.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 1.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.7 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 2.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.4 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.4 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.3 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 1.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.7 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 4.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.5 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 1.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 1.0 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.3 GO:0005497 androgen binding(GO:0005497)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.5 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 0.8 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.5 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 2.7 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 1.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 2.5 GO:0004527 exonuclease activity(GO:0004527)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 1.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 1.4 GO:0043022 ribosome binding(GO:0043022)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 3.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 3.2 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 6.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 6.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 1.1 GO:0016209 antioxidant activity(GO:0016209)
0.0 2.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 1.6 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0030145 manganese ion binding(GO:0030145)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 20.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 3.1 ST GA12 PATHWAY G alpha 12 Pathway
0.1 1.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 3.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 4.0 PID SHP2 PATHWAY SHP2 signaling
0.0 4.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 4.7 PID FGF PATHWAY FGF signaling pathway
0.0 2.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 3.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID IL27 PATHWAY IL27-mediated signaling events
0.0 10.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.4 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.3 4.7 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.3 15.5 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 3.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 3.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 3.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 7.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 3.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 5.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 2.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 2.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 5.4 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.6 REACTOME KINESINS Genes involved in Kinesins
0.0 2.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.8 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.7 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.8 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.2 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.9 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 1.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.2 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 1.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins