ISMARA results: GCM2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GCM2

Z-value: 2.64

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Transcription factors associated with GCM2

Gene Symbol	Gene ID	Gene Info
GCM2 Ensembl NCBI GeneCards UniProt	ENSG00000124827.6	glial cells missing transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GCM2	hg19_v2_chr6_-_10882174_10882274	0.12	6.0e-01	Click!

Activity profile of GCM2 motif

Sorted Z-values of GCM2 motif

No targets for GCM2

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.1	GO:0042493	response to drug(GO:0042493)
0.3	7.2	GO:0031167	rRNA methylation(GO:0031167)
0.2	5.8	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
1.4	5.5	GO:0006601	creatine biosynthetic process(GO:0006601)
0.3	5.4	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
1.7	5.2	GO:0015882	L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.5	5.2	GO:0046078	dUMP metabolic process(GO:0046078)
0.2	5.2	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.4	4.9	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.8	4.7	GO:1903412	response to bile acid(GO:1903412)

Showing 1 to 10 of 143 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	11.5	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.7	5.4	GO:1990393	3M complex(GO:1990393)
0.0	5.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.1	5.2	GO:0009925	basal plasma membrane(GO:0009925)
1.5	4.6	GO:0098855	HCN channel complex(GO:0098855)
0.0	4.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.4	3.9	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.1	3.9	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	3.6	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	3.5	GO:0046658	anchored component of plasma membrane(GO:0046658)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	15.9	GO:0070410	co-SMAD binding(GO:0070410)
1.2	7.2	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0	6.4	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.0	6.1	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4	5.7	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
1.8	5.5	GO:0015067	amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068)
0.2	5.4	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
1.7	5.2	GO:0070890	L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.2	5.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.4	4.7	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)

Showing 1 to 10 of 106 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.0	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	10.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	4.7	PID FGF PATHWAY	FGF signaling pathway
0.0	4.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	4.0	PID SHP2 PATHWAY	SHP2 signaling
0.0	3.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	3.7	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	3.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	3.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	3.1	ST GA12 PATHWAY	G alpha 12 Pathway

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.5	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	7.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	5.4	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.3	5.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	5.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.3	4.7	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.2	3.9	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.2	3.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	3.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	3.2	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors

Showing 1 to 10 of 44 entries

Results for GCM2

Z-value: 2.64

Motif logo

Transcription factors associated with GCM2

Activity-expression correlation:

Activity profile of GCM2 motif

Sorted Z-values of GCM2 motif

No targets for GCM2

Network of associatons between targets according to the STRING database.

First level regulatory network of GCM2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: