ISMARA results: GLIS2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GLIS2

Z-value: 3.31

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Transcription factors associated with GLIS2

Gene Symbol	Gene ID	Gene Info
GLIS2 Ensembl NCBI GeneCards UniProt	ENSG00000126603.4	GLIS family zinc finger 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GLIS2	hg19_v2_chr16_+_4382225_4382225	0.86	1.2e-06	Click!

Activity profile of GLIS2 motif

Sorted Z-values of GLIS2 motif

No targets for GLIS2

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.2	28.9	GO:0010900	negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.2	16.9	GO:0031572	G2 DNA damage checkpoint(GO:0031572)
0.1	14.8	GO:0007219	Notch signaling pathway(GO:0007219)
4.3	12.9	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
4.1	12.4	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1	12.3	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
1.3	11.7	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.3	11.1	GO:0051412	response to corticosterone(GO:0051412)
0.6	10.0	GO:0030238	male sex determination(GO:0030238)
1.5	9.2	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)

Showing 1 to 10 of 191 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	26.6	GO:0042627	chylomicron(GO:0042627)
0.1	23.5	GO:0008021	synaptic vesicle(GO:0008021)
0.2	16.4	GO:0035580	specific granule lumen(GO:0035580)
0.0	15.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.6	12.8	GO:0042613	MHC class II protein complex(GO:0042613)
0.2	11.3	GO:0097546	ciliary base(GO:0097546)
0.7	9.3	GO:0042788	polysomal ribosome(GO:0042788)
0.1	8.9	GO:0005901	caveola(GO:0005901)
0.3	8.0	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	7.2	GO:0000145	exocyst(GO:0000145)

Showing 1 to 10 of 98 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	26.6	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.7	18.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	15.8	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	14.3	GO:0004857	enzyme inhibitor activity(GO:0004857)
4.1	12.4	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.4	12.4	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.4	12.3	GO:0004806	triglyceride lipase activity(GO:0004806)
0.1	11.9	GO:0020037	heme binding(GO:0020037)
0.2	10.1	GO:0000217	DNA secondary structure binding(GO:0000217)
0.0	8.8	GO:0005178	integrin binding(GO:0005178)

Showing 1 to 10 of 142 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.1	PID LKB1 PATHWAY	LKB1 signaling events
0.0	12.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	9.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	8.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	7.7	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	7.1	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	5.9	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	5.8	PID ALK2 PATHWAY	ALK2 signaling events
0.1	5.4	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	5.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.9	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	10.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	9.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	8.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	7.5	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.5	7.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	6.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.3	6.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.2	5.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	4.8	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis

Showing 1 to 10 of 49 entries

Results for GLIS2

Z-value: 3.31

Motif logo

Transcription factors associated with GLIS2

Activity-expression correlation:

Activity profile of GLIS2 motif

Sorted Z-values of GLIS2 motif

No targets for GLIS2

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: