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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GRHL1
Z-value: 3.55
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Transcription factors associated with GRHL1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GRHL1
|
ENSG00000134317.13 | grainyhead like transcription factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GRHL1 | hg19_v2_chr2_+_10091783_10091811 | 0.96 | 1.3e-11 | Click! |
Activity profile of GRHL1 motif
Sorted Z-values of GRHL1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GRHL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 26.6 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 3.5 | 10.5 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 1.1 | 6.6 | GO:0060214 | endocardium formation(GO:0060214) |
| 0.8 | 5.6 | GO:0045229 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.8 | 7.7 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.7 | 2.8 | GO:0035188 | blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684) |
| 0.6 | 1.8 | GO:0046901 | tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901) |
| 0.6 | 9.5 | GO:0015871 | choline transport(GO:0015871) |
| 0.5 | 4.3 | GO:1902714 | antifungal humoral response(GO:0019732) negative regulation of interferon-gamma secretion(GO:1902714) |
| 0.5 | 12.6 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.5 | 5.1 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.4 | 1.3 | GO:2001027 | negative regulation of endothelial cell chemotaxis(GO:2001027) |
| 0.4 | 4.4 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.3 | 3.5 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.3 | 0.9 | GO:0021650 | vestibulocochlear nerve formation(GO:0021650) |
| 0.2 | 2.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.2 | 4.6 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.2 | 5.5 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.2 | 4.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 2.2 | GO:0045046 | protein import into peroxisome membrane(GO:0045046) |
| 0.1 | 2.7 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 13.8 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.1 | 6.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 5.5 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.1 | 1.0 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.1 | 0.8 | GO:1901341 | activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341) |
| 0.1 | 0.7 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.1 | 10.8 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.1 | 7.0 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 2.5 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 0.1 | GO:0071586 | prenylated protein catabolic process(GO:0030327) CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120) |
| 0.0 | 1.8 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
| 0.0 | 0.1 | GO:0006424 | glutamyl-tRNA aminoacylation(GO:0006424) |
| 0.0 | 2.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 1.0 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.0 | 0.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.0 | 0.3 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.5 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 6.0 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
| 0.0 | 1.9 | GO:0016575 | histone deacetylation(GO:0016575) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 26.6 | GO:0044393 | microspike(GO:0044393) |
| 0.7 | 19.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.4 | 4.0 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.4 | 11.4 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.2 | 2.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.2 | 4.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 7.0 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.2 | 12.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 27.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.5 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.1 | 1.9 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 10.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 2.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 1.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 9.5 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 5.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.3 | GO:0036019 | endolysosome(GO:0036019) |
| 0.0 | 7.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 3.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 2.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 3.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 5.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.9 | GO:0032420 | stereocilium(GO:0032420) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.5 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.9 | 4.3 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.7 | 13.8 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.6 | 1.8 | GO:0008841 | tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841) |
| 0.4 | 5.6 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.3 | 5.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.3 | 26.6 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 2.5 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.2 | 12.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 5.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 7.7 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 2.8 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 4.0 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 11.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.1 | 0.7 | GO:0042835 | BRE binding(GO:0042835) |
| 0.1 | 1.9 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 0.9 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.1 | 6.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.8 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 31.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 1.3 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.1 | GO:0004818 | glutamate-tRNA ligase activity(GO:0004818) |
| 0.0 | 1.0 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 8.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.3 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 7.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 1.9 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 2.2 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 2.7 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 3.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 5.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 4.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 17.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 7.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 7.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.3 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 2.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.9 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 5.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 19.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.4 | 12.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.3 | 7.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.3 | 9.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 4.4 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 4.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 2.5 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.0 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 2.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 2.8 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 1.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |