ISMARA results: GRHL1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GRHL1

Z-value: 3.55

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Transcription factors associated with GRHL1

Gene Symbol	Gene ID	Gene Info
GRHL1 Ensembl NCBI GeneCards UniProt	ENSG00000134317.13	grainyhead like transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GRHL1	hg19_v2_chr2_+_10091783_10091811	0.96	1.3e-11	Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

No targets for GRHL1

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.7	26.6	GO:2001287	negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1	13.8	GO:0071300	cellular response to retinoic acid(GO:0071300)
0.5	12.6	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1	10.8	GO:0006368	transcription elongation from RNA polymerase II promoter(GO:0006368)
3.5	10.5	GO:1902173	negative regulation of keratinocyte apoptotic process(GO:1902173)
0.6	9.5	GO:0015871	choline transport(GO:0015871)
0.8	7.7	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.1	7.0	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
1.1	6.6	GO:0060214	endocardium formation(GO:0060214)
0.1	6.6	GO:0018149	peptide cross-linking(GO:0018149)

Showing 1 to 10 of 40 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	27.2	GO:0005604	basement membrane(GO:0005604)
5.3	26.6	GO:0044393	microspike(GO:0044393)
0.7	19.4	GO:0005922	connexon complex(GO:0005922)
0.2	12.2	GO:0001533	cornified envelope(GO:0001533)
0.4	11.4	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.1	10.9	GO:0043202	lysosomal lumen(GO:0043202)
0.1	9.5	GO:0035579	specific granule membrane(GO:0035579)
0.0	7.7	GO:0005923	bicellular tight junction(GO:0005923)
0.2	7.0	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	5.5	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 24 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	31.4	GO:0045296	cadherin binding(GO:0045296)
0.3	26.6	GO:0015485	cholesterol binding(GO:0015485)
0.7	13.8	GO:0005243	gap junction channel activity(GO:0005243)
0.2	12.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	11.7	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.1	9.5	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	8.9	GO:0017124	SH3 domain binding(GO:0017124)
0.1	7.7	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	7.0	GO:0030674	protein binding, bridging(GO:0030674)
0.1	6.0	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)

Showing 1 to 10 of 30 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	12.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	7.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	7.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	5.5	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	5.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	4.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.8	PID BARD1 PATHWAY	BARD1 signaling events
0.0	2.5	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.9	PID P53 REGULATION PATHWAY	p53 pathway

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	19.4	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.4	12.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.3	9.5	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.3	7.7	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	4.4	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.1	4.0	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	2.8	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	2.5	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	2.4	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	1.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors

Showing 1 to 10 of 12 entries

Results for GRHL1

Z-value: 3.55

Motif logo

Transcription factors associated with GRHL1

Activity-expression correlation:

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

No targets for GRHL1

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: