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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HBP1

Z-value: 1.08

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Transcription factors associated with HBP1

Gene Symbol Gene ID Gene Info
ENSG00000105856.9 HMG-box transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HBP1hg19_v2_chr7_+_106810165_106810374-0.331.6e-01Click!

Activity profile of HBP1 motif

Sorted Z-values of HBP1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.3 1.3 GO:0000103 sulfate assimilation(GO:0000103)
0.3 1.2 GO:0019521 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.3 0.9 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 1.0 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.2 1.0 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.2 0.6 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.2 0.7 GO:0072615 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.2 1.3 GO:1902847 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2 0.5 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.2 0.5 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.1 1.5 GO:0030259 lipid glycosylation(GO:0030259)
0.1 0.7 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1 0.4 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.1 0.3 GO:0070121 pronephric nephron morphogenesis(GO:0039007) pronephric nephron tubule morphogenesis(GO:0039008) pronephric duct development(GO:0039022) pronephric duct morphogenesis(GO:0039023) Kupffer's vesicle development(GO:0070121)
0.1 3.0 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 1.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.8 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 1.5 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0046356 acetyl-CoA catabolic process(GO:0046356)
0.1 0.5 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 1.5 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.1 0.7 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1 0.6 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.1 0.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.3 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.2 GO:1990051 activation of protein kinase C activity(GO:1990051)
0.1 0.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 1.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.8 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.3 GO:1990523 bone regeneration(GO:1990523)
0.1 0.5 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.9 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.4 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.4 GO:0048478 replication fork protection(GO:0048478)
0.0 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.5 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.0 0.7 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.4 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.4 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0 0.5 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.2 GO:1901382 chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.2 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 1.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 1.6 GO:0061615 NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.1 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.5 GO:0019388 galactose catabolic process(GO:0019388)
0.0 1.0 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.2 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0035377 transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.1 GO:1901076 positive regulation of engulfment of apoptotic cell(GO:1901076)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.3 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.3 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
0.0 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.3 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.3 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.5 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.0 GO:0040040 thermosensory behavior(GO:0040040)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.3 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 0.3 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.0 0.1 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.6 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.3 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.2 GO:0021756 striatum development(GO:0021756)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.2 1.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.7 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.8 GO:0031298 replication fork protection complex(GO:0031298)
0.1 4.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.9 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.4 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:0005683 U7 snRNP(GO:0005683)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.9 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 3.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.4 2.2 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.3 1.5 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.3 1.4 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.2 1.3 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.2 1.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 1.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.2 0.7 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.2 0.5 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.2 0.5 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.1 1.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.5 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.1 1.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.3 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 1.8 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.7 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 1.0 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.3 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 0.3 GO:0004905 type I interferon receptor activity(GO:0004905)
0.1 0.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 3.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.6 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.3 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0030350 iron-responsive element binding(GO:0030350)
0.0 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.4 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 1.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 2.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0051765 inositol tetrakisphosphate kinase activity(GO:0051765)
0.0 0.1 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.4 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.0 0.1 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.5 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.0 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.2 ST GAQ PATHWAY G alpha q Pathway
0.0 2.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.0 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.8 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.4 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.3 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling