ISMARA results: HDX

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HDX

Z-value: 0.76

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Transcription factors associated with HDX

Gene Symbol	Gene ID	Gene Info
HDX Ensembl NCBI GeneCards UniProt	ENSG00000165259.9	highly divergent homeobox

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HDX	hg19_v2_chrX_-_83757399_83757487	0.76	1.0e-04	Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

No targets for HDX

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.9	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.2	3.6	GO:0032119	sequestering of zinc ion(GO:0032119)
0.0	2.5	GO:0070268	cornification(GO:0070268)
0.4	2.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	1.8	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	1.5	GO:0042905	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2	1.2	GO:0030311	poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1	0.3	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1	0.2	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)

Showing 1 to 9 of 9 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.6	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.1	2.5	GO:0030057	desmosome(GO:0030057)
0.2	1.8	GO:0005610	laminin-5 complex(GO:0005610)

Showing 1 to 3 of 3 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	6.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.5	3.6	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	1.5	GO:0047035	alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2	1.2	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.6	GO:0070330	aromatase activity(GO:0070330)
0.1	0.4	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.3	GO:0070728	leucine binding(GO:0070728)
0.0	0.2	GO:0023024	MHC class I protein complex binding(GO:0023024)

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	3.6	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	1.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	1.8	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	1.2	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins

Showing 1 to 4 of 4 entries

Results for HDX

Z-value: 0.76

Motif logo

Transcription factors associated with HDX

Activity-expression correlation:

Activity profile of HDX motif

Sorted Z-values of HDX motif

No targets for HDX

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: