Project
avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HDX
Z-value: 0.76
Motif logo
Transcription factors associated with HDX
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HDX
|
ENSG00000165259.9 | highly divergent homeobox |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HDX | hg19_v2_chrX_-_83757399_83757487 | 0.76 | 1.0e-04 | Click! |
Activity profile of HDX motif
Sorted Z-values of HDX motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HDX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.9 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.4 | 2.1 | GO:0002282 | microglial cell activation involved in immune response(GO:0002282) |
| 0.2 | 1.2 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.2 | 3.6 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 0.1 | 1.5 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.3 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.1 | 0.2 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.0 | 1.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 2.5 | GO:0070268 | cornification(GO:0070268) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 2.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 3.6 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.6 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.2 | 6.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 1.2 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.1 | 1.5 | GO:0047035 | alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.1 | 0.4 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.0 | 0.2 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 0.3 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.6 | GO:0070330 | aromatase activity(GO:0070330) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 3.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.2 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |