ISMARA results: HES1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HES1

Z-value: 2.42

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Transcription factors associated with HES1

Gene Symbol	Gene ID	Gene Info
HES1 Ensembl NCBI GeneCards UniProt	ENSG00000114315.3	hes family bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HES1	hg19_v2_chr3_+_193853927_193853944	-0.62	3.5e-03	Click!

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

No targets for HES1

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.3	GO:0061718	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
1.2	6.0	GO:0019242	methylglyoxal biosynthetic process(GO:0019242)
1.8	5.5	GO:0043181	vacuolar sequestering(GO:0043181)
0.4	5.5	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1	5.3	GO:0035329	hippo signaling(GO:0035329)
0.4	5.2	GO:0030050	vesicle transport along actin filament(GO:0030050)
1.0	4.9	GO:0036343	psychomotor behavior(GO:0036343)
0.6	4.8	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0	4.6	GO:0021543	pallium development(GO:0021543)
1.4	4.2	GO:0007037	vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)

Showing 1 to 10 of 345 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	7.4	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.1	7.3	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	7.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.3	5.5	GO:0031209	SCAR complex(GO:0031209)
0.3	5.0	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	4.6	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	4.6	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	4.3	GO:0005901	caveola(GO:0005901)
0.1	3.8	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	3.7	GO:0032993	protein-DNA complex(GO:0032993)

Showing 1 to 10 of 138 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	7.4	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
1.2	6.0	GO:0004347	glucose-6-phosphate isomerase activity(GO:0004347)
0.2	5.6	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
1.8	5.5	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.1	5.2	GO:0019212	phosphatase inhibitor activity(GO:0019212)
1.4	4.1	GO:0004513	neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.0	4.1	GO:0017022	myosin binding(GO:0017022)
0.8	3.9	GO:0010736	serum response element binding(GO:0010736)
0.6	3.9	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2	3.8	GO:0005542	folic acid binding(GO:0005542)

Showing 1 to 10 of 218 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.3	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	5.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	5.7	PID AURORA A PATHWAY	Aurora A signaling
0.1	3.9	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	3.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	2.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	2.7	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	2.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.6	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	2.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	13.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	7.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	6.7	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.3	6.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	6.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3	5.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.3	4.2	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	4.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	3.6	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	3.5	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway

Showing 1 to 10 of 74 entries

Results for HES1

Z-value: 2.42

Motif logo

Transcription factors associated with HES1

Activity-expression correlation:

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

No targets for HES1

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: