ISMARA results: HES7

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HES7_HES5

Z-value: 0.98

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Transcription factors associated with HES7_HES5

Gene Symbol	Gene ID	Gene Info
HES7 Ensembl NCBI GeneCards UniProt	ENSG00000179111.4	hes family bHLH transcription factor 7
HES5 Ensembl NCBI GeneCards UniProt	ENSG00000197921.5	hes family bHLH transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HES5	hg19_v2_chr1_-_2461684_2461710	0.69	7.4e-04	Click!
HES7	hg19_v2_chr17_-_8027402_8027432	-0.53	1.6e-02	Click!

Activity profile of HES7_HES5 motif

Sorted Z-values of HES7_HES5 motif

No targets for HES7_HES5

Network of associatons between targets according to the STRING database.

First level regulatory network of HES7_HES5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.5	GO:0015816	glycine transport(GO:0015816)
0.0	4.0	GO:0006493	protein O-linked glycosylation(GO:0006493)
0.5	2.9	GO:1902957	negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957)
0.0	1.7	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.0	1.6	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1	1.3	GO:0016576	histone dephosphorylation(GO:0016576)
0.1	1.1	GO:1902952	positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.3	1.0	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	1.0	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1	0.9	GO:0030050	vesicle transport along actin filament(GO:0030050)

Showing 1 to 10 of 55 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	1.1	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.9	GO:0031045	dense core granule(GO:0031045)
0.2	0.6	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	0.6	GO:0089701	U2AF(GO:0089701)
0.0	0.6	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.1	0.5	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.5	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.5	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.5	GO:0016580	Sin3 complex(GO:0016580)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	5.5	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.6	3.8	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2	1.7	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	1.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	1.3	GO:0031005	filamin binding(GO:0031005)
0.1	1.1	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.0	1.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.9	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.7	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2	0.6	GO:0016534	cyclin-dependent protein kinase 5 activator activity(GO:0016534)

Showing 1 to 10 of 40 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
1.8	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
1.2	PID REELIN PATHWAY	Reelin signaling pathway
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	PID LPA4 PATHWAY	LPA4-mediated signaling events

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.8	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.9	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.6	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.4	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway

Showing 1 to 8 of 8 entries

Results for HES7_HES5

Z-value: 0.98

Motif logo

Transcription factors associated with HES7_HES5

Activity-expression correlation:

Activity profile of HES7_HES5 motif

Sorted Z-values of HES7_HES5 motif

No targets for HES7_HES5

Network of associatons between targets according to the STRING database.

First level regulatory network of HES7_HES5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: