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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HES7_HES5
Z-value: 0.98
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Transcription factors associated with HES7_HES5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HES7
|
ENSG00000179111.4 | hes family bHLH transcription factor 7 |
|
HES5
|
ENSG00000197921.5 | hes family bHLH transcription factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HES5 | hg19_v2_chr1_-_2461684_2461710 | 0.69 | 7.4e-04 | Click! |
| HES7 | hg19_v2_chr17_-_8027402_8027432 | -0.53 | 1.6e-02 | Click! |
Activity profile of HES7_HES5 motif
Sorted Z-values of HES7_HES5 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HES7_HES5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.9 | GO:1902957 | negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957) |
| 0.3 | 1.0 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.3 | 5.5 | GO:0015816 | glycine transport(GO:0015816) |
| 0.2 | 0.7 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.2 | 0.6 | GO:0021722 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.1 | 1.1 | GO:1902952 | positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.1 | 0.6 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.1 | 0.3 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
| 0.1 | 0.3 | GO:0042668 | auditory receptor cell fate determination(GO:0042668) |
| 0.1 | 0.7 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.1 | 0.3 | GO:0090222 | centrosome-templated microtubule nucleation(GO:0090222) |
| 0.1 | 0.5 | GO:1902045 | negative regulation of Fas signaling pathway(GO:1902045) |
| 0.1 | 0.2 | GO:0006433 | glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433) |
| 0.1 | 1.3 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 0.2 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.1 | 0.4 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.1 | 0.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.1 | 0.2 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.1 | 0.6 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 0.9 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.1 | 0.4 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.0 | 0.5 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 1.0 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.8 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.0 | 1.7 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.6 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 0.5 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.0 | 0.1 | GO:0050976 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) |
| 0.0 | 0.9 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.0 | 0.1 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.0 | 0.3 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.0 | 0.6 | GO:0002031 | G-protein coupled receptor internalization(GO:0002031) |
| 0.0 | 0.3 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.0 | 0.1 | GO:0033685 | negative regulation of luteinizing hormone secretion(GO:0033685) |
| 0.0 | 0.4 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.0 | 0.3 | GO:2000781 | positive regulation of double-strand break repair(GO:2000781) |
| 0.0 | 4.0 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.6 | GO:0090141 | positive regulation of mitochondrial fission(GO:0090141) |
| 0.0 | 0.4 | GO:0002097 | tRNA wobble base modification(GO:0002097) |
| 0.0 | 0.1 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.0 | 0.2 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.0 | 0.4 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.2 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.0 | 0.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.1 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.0 | 0.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.1 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.0 | 0.3 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.0 | 0.3 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.1 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.0 | 0.2 | GO:0045141 | meiotic telomere clustering(GO:0045141) |
| 0.0 | 0.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 1.6 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.0 | 0.3 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.0 | 0.3 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 0.6 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 0.5 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.1 | 0.2 | GO:0005953 | CAAX-protein geranylgeranyltransferase complex(GO:0005953) |
| 0.1 | 0.4 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.5 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.1 | GO:0043614 | multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451) |
| 0.0 | 0.9 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.2 | GO:0044308 | axonal spine(GO:0044308) |
| 0.0 | 0.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.2 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.0 | 0.4 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 0.1 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.0 | 0.1 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.0 | 0.6 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 2.9 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.5 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 0.3 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.1 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.0 | 0.2 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.3 | GO:0071004 | U2 snRNP(GO:0005686) U2-type prespliceosome(GO:0071004) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 1.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.8 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.4 | 5.5 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.2 | 0.6 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.2 | 0.6 | GO:0050254 | rhodopsin kinase activity(GO:0050254) |
| 0.2 | 1.7 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 1.1 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 0.3 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.1 | 0.3 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.1 | 0.2 | GO:0004827 | glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827) |
| 0.1 | 0.2 | GO:0004662 | CAAX-protein geranylgeranyltransferase activity(GO:0004662) |
| 0.1 | 0.6 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.1 | 0.6 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.0 | 0.2 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.0 | 1.3 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.3 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.0 | 0.1 | GO:0098782 | mechanically-gated potassium channel activity(GO:0098782) |
| 0.0 | 0.4 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 0.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.1 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.0 | 0.4 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.0 | 0.4 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 1.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.2 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.0 | 0.2 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.0 | 0.7 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.1 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.0 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 0.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.3 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.0 | 0.4 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.6 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 0.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.1 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.1 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
| 0.0 | 0.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.9 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.1 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.8 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.8 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.3 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 0.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |