ISMARA results: HIC2

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HIC2

Z-value: 3.08

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Transcription factors associated with HIC2

Gene Symbol	Gene ID	Gene Info
HIC2 Ensembl NCBI GeneCards UniProt	ENSG00000169635.5	HIC ZBTB transcriptional repressor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC2	hg19_v2_chr22_+_21771656_21771693	0.37	1.1e-01	Click!

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

No targets for HIC2

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	17.9	GO:0030449	regulation of complement activation(GO:0030449)
0.1	7.2	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3	6.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	6.7	GO:0050434	positive regulation of viral transcription(GO:0050434)
1.2	5.8	GO:0009440	cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.3	5.1	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1	5.1	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.2	4.7	GO:0010764	negative regulation of fibroblast migration(GO:0010764)
0.6	4.3	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.2	4.3	GO:0051601	exocyst localization(GO:0051601)

Showing 1 to 10 of 601 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.9	GO:0072562	blood microparticle(GO:0072562)
0.1	7.1	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	6.5	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	5.8	GO:0031201	SNARE complex(GO:0031201)
0.0	5.3	GO:0008021	synaptic vesicle(GO:0008021)
0.1	5.2	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	5.0	GO:0016324	apical plasma membrane(GO:0016324)
0.0	4.9	GO:0005776	autophagosome(GO:0005776)
0.5	4.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.2	4.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)

Showing 1 to 10 of 209 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	12.8	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	7.1	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	6.9	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
1.0	5.8	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.1	5.8	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	5.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.3	5.1	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.0	5.0	GO:0000149	SNARE binding(GO:0000149)
0.1	4.6	GO:0005484	SNAP receptor activity(GO:0005484)

Showing 1 to 10 of 387 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	6.0	NABA COLLAGENS	Genes encoding collagen proteins
0.0	4.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	4.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	2.7	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	2.6	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	2.6	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	2.5	PID BMP PATHWAY	BMP receptor signaling
0.0	2.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	2.2	ST P38 MAPK PATHWAY	p38 MAPK Pathway

Showing 1 to 10 of 58 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.3	7.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	6.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	5.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	5.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	5.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	5.1	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	4.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	4.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	4.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 106 entries

Results for HIC2

Z-value: 3.08

Motif logo

Transcription factors associated with HIC2

Activity-expression correlation:

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

No targets for HIC2

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: