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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HIF1A
Z-value: 0.94
Motif logo
Transcription factors associated with HIF1A
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HIF1A
|
ENSG00000100644.12 | hypoxia inducible factor 1 subunit alpha |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIF1A | hg19_v2_chr14_+_62164340_62164443 | 0.86 | 1.1e-06 | Click! |
Activity profile of HIF1A motif
Sorted Z-values of HIF1A motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HIF1A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0015728 | mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780) |
| 0.5 | 1.8 | GO:0018277 | protein deamination(GO:0018277) |
| 0.4 | 1.7 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.3 | 1.4 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.2 | 0.7 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.2 | 1.3 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) |
| 0.2 | 0.7 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.2 | 1.5 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.2 | 0.6 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.2 | 1.5 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.2 | 1.1 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.2 | 0.8 | GO:0042360 | vitamin E metabolic process(GO:0042360) |
| 0.2 | 0.8 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.2 | 0.5 | GO:0044209 | AMP salvage(GO:0044209) |
| 0.2 | 0.5 | GO:0007057 | spindle assembly involved in female meiosis I(GO:0007057) |
| 0.1 | 0.7 | GO:1990569 | UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569) |
| 0.1 | 0.4 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 0.1 | 0.8 | GO:2000301 | response to antineoplastic agent(GO:0097327) negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.1 | 0.5 | GO:2000176 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.1 | 1.2 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 0.1 | 0.8 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 0.8 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.1 | 0.4 | GO:0046946 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 0.1 | 0.4 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.1 | 0.5 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.1 | 0.3 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
| 0.1 | 0.6 | GO:0048817 | negative regulation of hair follicle maturation(GO:0048817) |
| 0.1 | 1.3 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 0.7 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.1 | 0.4 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 0.4 | GO:0019417 | sulfur oxidation(GO:0019417) |
| 0.1 | 0.3 | GO:0035281 | pre-miRNA export from nucleus(GO:0035281) |
| 0.1 | 0.9 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.1 | 0.4 | GO:1902904 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.1 | 0.7 | GO:0021592 | fourth ventricle development(GO:0021592) |
| 0.1 | 0.4 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 0.1 | 1.3 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.1 | 1.1 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.1 | 0.5 | GO:1900041 | negative regulation of interleukin-2 secretion(GO:1900041) |
| 0.1 | 0.4 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.1 | 0.4 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.1 | 0.4 | GO:1902534 | single-organism membrane invagination(GO:1902534) |
| 0.1 | 0.8 | GO:1902459 | positive regulation of stem cell population maintenance(GO:1902459) |
| 0.1 | 1.6 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 0.9 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 1.1 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.1 | 0.2 | GO:0000294 | nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294) |
| 0.1 | 0.6 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 0.2 | GO:0046166 | glyceraldehyde-3-phosphate biosynthetic process(GO:0046166) |
| 0.1 | 0.4 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 0.6 | GO:0043697 | dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) |
| 0.1 | 0.7 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.1 | 0.5 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 0.3 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 0.0 | 0.4 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.0 | 0.2 | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) |
| 0.0 | 0.1 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.0 | 0.4 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.4 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.0 | 0.9 | GO:0046852 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.0 | 1.3 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.0 | 0.8 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 0.7 | GO:0021702 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 0.2 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.0 | 0.7 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 0.4 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.2 | GO:0016259 | selenocysteine metabolic process(GO:0016259) |
| 0.0 | 0.7 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.4 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.0 | 0.2 | GO:0070213 | protein auto-ADP-ribosylation(GO:0070213) |
| 0.0 | 0.1 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.0 | 0.4 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.7 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 0.6 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.0 | 0.9 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 0.4 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.0 | 0.3 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.0 | 0.2 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 0.0 | 1.4 | GO:0060441 | epithelial tube branching involved in lung morphogenesis(GO:0060441) |
| 0.0 | 0.8 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.4 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.0 | 0.1 | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) |
| 0.0 | 0.7 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.3 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.0 | 0.4 | GO:1904179 | osteoblast fate commitment(GO:0002051) positive regulation of adipose tissue development(GO:1904179) |
| 0.0 | 0.6 | GO:0015812 | gamma-aminobutyric acid transport(GO:0015812) |
| 0.0 | 0.2 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.0 | 0.1 | GO:0046504 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.0 | 2.7 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.1 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.0 | 0.2 | GO:1990253 | positive regulation of TORC1 signaling(GO:1904263) cellular response to leucine starvation(GO:1990253) |
| 0.0 | 0.4 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.0 | 0.5 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.0 | 0.2 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.0 | 0.6 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.0 | 0.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.7 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 0.0 | 0.4 | GO:1904354 | negative regulation of telomere capping(GO:1904354) |
| 0.0 | 0.8 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 1.3 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.5 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.0 | 0.1 | GO:0006424 | glutamyl-tRNA aminoacylation(GO:0006424) |
| 0.0 | 0.1 | GO:0032849 | positive regulation of cellular pH reduction(GO:0032849) |
| 0.0 | 0.4 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.0 | 0.4 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.0 | 0.2 | GO:0021603 | cranial nerve formation(GO:0021603) |
| 0.0 | 0.4 | GO:0034384 | high-density lipoprotein particle clearance(GO:0034384) |
| 0.0 | 0.1 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.0 | 0.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.9 | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) |
| 0.0 | 0.8 | GO:0000075 | cell cycle checkpoint(GO:0000075) |
| 0.0 | 0.4 | GO:0048490 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.2 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 0.0 | 0.1 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.0 | 0.1 | GO:0003138 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.0 | 0.2 | GO:0000101 | sulfur amino acid transport(GO:0000101) |
| 0.0 | 0.8 | GO:0034724 | DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724) |
| 0.0 | 0.1 | GO:0006308 | DNA catabolic process(GO:0006308) |
| 0.0 | 0.7 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 0.3 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.6 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 1.3 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.6 | GO:0031440 | regulation of mRNA 3'-end processing(GO:0031440) |
| 0.0 | 0.2 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 0.4 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.3 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 0.7 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.2 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 0.3 | GO:0071539 | protein localization to centrosome(GO:0071539) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.2 | 0.9 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.2 | 0.7 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.2 | 0.8 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.1 | 0.9 | GO:1905202 | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202) |
| 0.1 | 1.2 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.1 | 0.8 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.1 | 0.7 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 1.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 1.9 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 0.3 | GO:0042565 | RNA nuclear export complex(GO:0042565) |
| 0.1 | 0.9 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.1 | 0.3 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.1 | 0.9 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.1 | 0.4 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.1 | 0.4 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.1 | 0.5 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 2.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.1 | 0.4 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.1 | 0.3 | GO:0031417 | NatC complex(GO:0031417) |
| 0.1 | 0.9 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.1 | 0.7 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.1 | 0.6 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.1 | 0.8 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 0.5 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.7 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.7 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.6 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.2 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.2 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 0.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.4 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.8 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.7 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.0 | 0.3 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.9 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.3 | GO:0099738 | cell cortex region(GO:0099738) |
| 0.0 | 0.1 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.4 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.8 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 2.1 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.8 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.4 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.1 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.0 | 0.5 | GO:0090544 | BAF-type complex(GO:0090544) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
| 0.3 | 0.9 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.3 | 1.1 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.2 | 0.6 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.2 | 1.6 | GO:0019798 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.2 | 1.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.1 | 0.9 | GO:0004485 | methylcrotonoyl-CoA carboxylase activity(GO:0004485) |
| 0.1 | 0.7 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
| 0.1 | 0.4 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.1 | 1.7 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.4 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 0.1 | 0.7 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 0.3 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.1 | 0.3 | GO:0051377 | mannose-ethanolamine phosphotransferase activity(GO:0051377) |
| 0.1 | 0.6 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.1 | 0.5 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 0.7 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.1 | 0.3 | GO:0090631 | pre-miRNA transporter activity(GO:0090631) |
| 0.1 | 0.4 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.1 | 0.7 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.1 | 0.7 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 0.4 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 0.2 | GO:0004807 | triose-phosphate isomerase activity(GO:0004807) |
| 0.1 | 1.8 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 0.7 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.1 | 0.4 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.1 | 0.1 | GO:0004818 | glutamate-tRNA ligase activity(GO:0004818) |
| 0.1 | 0.4 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.1 | 1.8 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 0.9 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.6 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 0.5 | GO:0055104 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 1.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.4 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.4 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 0.9 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 2.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.8 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.8 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.7 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 1.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.4 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 0.2 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.0 | 1.1 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.3 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.0 | 1.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.6 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.2 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.0 | 0.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.7 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.2 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.8 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.6 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.8 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 1.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.4 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.0 | 0.4 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.1 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.0 | 0.1 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.0 | 1.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.4 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.1 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.0 | 0.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.2 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.0 | 0.5 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.0 | 0.4 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.9 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.0 | 0.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 0.6 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 0.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 1.6 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.1 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.0 | 0.4 | GO:0071949 | FAD binding(GO:0071949) |
| 0.0 | 6.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.2 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 2.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.2 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 1.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.3 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 2.2 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 1.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.4 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 1.5 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 1.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 0.8 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 2.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.8 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 0.9 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 0.6 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 0.3 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.4 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 2.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.3 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.2 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |