ISMARA results: HIF1A

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HIF1A

Z-value: 0.94

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Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt	ENSG00000100644.12	hypoxia inducible factor 1 subunit alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIF1A	hg19_v2_chr14_+_62164340_62164443	0.86	1.1e-06	Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

No targets for HIF1A

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	3.0	GO:0015728	mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.0	2.7	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.5	1.8	GO:0018277	protein deamination(GO:0018277)
0.4	1.7	GO:0060166	olfactory pit development(GO:0060166)
0.1	1.6	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.2	1.5	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.2	1.5	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.3	1.4	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	1.4	GO:0060441	epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.2	1.3	GO:0036353	histone H2A-K119 monoubiquitination(GO:0036353)

Showing 1 to 10 of 129 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	2.1	GO:0001669	acrosomal vesicle(GO:0001669)
0.1	1.9	GO:0097227	sperm annulus(GO:0097227)
0.2	1.4	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.0	1.4	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	1.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	1.3	GO:0099738	cell cortex region(GO:0099738)
0.1	1.2	GO:0070876	SOSS complex(GO:0070876)
0.0	1.1	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.2	0.9	GO:0097454	Schwann cell microvillus(GO:0097454)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.5	GO:0045296	cadherin binding(GO:0045296)
1.0	3.0	GO:0015130	mevalonate transmembrane transporter activity(GO:0015130)
0.0	2.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	2.0	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1	1.8	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	1.8	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1	1.7	GO:0070324	thyroid hormone binding(GO:0070324)
0.2	1.6	GO:0019798	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0	1.6	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	1.5	GO:0070888	E-box binding(GO:0070888)

Showing 1 to 10 of 85 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.4	PID PLK1 PATHWAY	PLK1 signaling events
2.2	PID CDC42 PATHWAY	CDC42 signaling events
2.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.8	PID P73PATHWAY	p73 transcription factor network
1.6	PID AURORA B PATHWAY	Aurora B signaling
1.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
1.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
1.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
1.5	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins

Showing 1 to 10 of 18 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.0	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	2.4	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	2.0	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.8	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	1.5	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	1.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	1.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	1.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	1.1	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.9	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER

Showing 1 to 10 of 31 entries

Results for HIF1A

Z-value: 0.94

Motif logo

Transcription factors associated with HIF1A

Activity-expression correlation:

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

No targets for HIF1A

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: