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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HLF_TEF
Z-value: 1.05
Motif logo
Transcription factors associated with HLF_TEF
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HLF
|
ENSG00000108924.9 | HLF transcription factor, PAR bZIP family member |
|
TEF
|
ENSG00000167074.10 | TEF transcription factor, PAR bZIP family member |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HLF | hg19_v2_chr17_+_53343171_53343207 | 0.65 | 1.8e-03 | Click! |
| TEF | hg19_v2_chr22_+_41777927_41777971 | -0.53 | 1.7e-02 | Click! |
Activity profile of HLF_TEF motif
Sorted Z-values of HLF_TEF motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HLF_TEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 14.1 | GO:1902998 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.3 | 1.3 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.3 | 2.6 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 0.2 | 0.7 | GO:0009443 | pyridoxal 5'-phosphate salvage(GO:0009443) |
| 0.1 | 0.4 | GO:1903567 | negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568) |
| 0.1 | 1.8 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.1 | 1.8 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 0.6 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
| 0.1 | 0.8 | GO:0071727 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.1 | 1.2 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.1 | 0.7 | GO:0048165 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.1 | 0.3 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.1 | 0.7 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.1 | 0.9 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 0.7 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.1 | 0.3 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 1.6 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 0.4 | GO:0036511 | trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512) |
| 0.1 | 0.4 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 0.2 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.0 | 0.8 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.0 | 0.9 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.2 | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) |
| 0.0 | 0.2 | GO:0050712 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
| 0.0 | 0.4 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.0 | 0.2 | GO:0045209 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.0 | 0.2 | GO:0097112 | gamma-aminobutyric acid receptor clustering(GO:0097112) |
| 0.0 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 4.1 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 0.0 | 0.1 | GO:0071348 | cellular response to interleukin-11(GO:0071348) |
| 0.0 | 0.3 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.0 | 0.2 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.0 | 0.2 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.0 | 0.1 | GO:0048749 | compound eye development(GO:0048749) |
| 0.0 | 0.7 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.0 | 0.9 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.2 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.0 | 0.2 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.0 | 0.1 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159) |
| 0.0 | 0.1 | GO:0001878 | response to yeast(GO:0001878) negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.0 | 0.3 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.4 | GO:0048266 | behavioral response to pain(GO:0048266) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.0 | 0.1 | GO:0070884 | calcineurin-NFAT signaling cascade(GO:0033173) regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.5 | GO:0044070 | regulation of anion transport(GO:0044070) |
| 0.0 | 0.1 | GO:0006983 | ER overload response(GO:0006983) |
| 0.0 | 0.4 | GO:0031065 | positive regulation of histone deacetylation(GO:0031065) |
| 0.0 | 0.3 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 0.1 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.0 | 0.1 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 1.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 0.7 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.0 | 0.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.1 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.0 | 0.2 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 0.2 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.0 | 0.2 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 14.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 0.8 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.7 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.3 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.2 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) |
| 0.1 | 0.6 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 1.5 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 1.0 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.0 | 0.2 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.0 | 2.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.8 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.2 | GO:0071942 | XPC complex(GO:0071942) |
| 0.0 | 0.3 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 3.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.5 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.3 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.0 | 0.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.3 | GO:0033178 | proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178) |
| 0.0 | 0.1 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.1 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.4 | 14.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.3 | 1.3 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.2 | 0.7 | GO:0008478 | pyridoxal kinase activity(GO:0008478) |
| 0.2 | 0.8 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 1.6 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 0.6 | GO:0031208 | POZ domain binding(GO:0031208) |
| 0.1 | 2.6 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 0.3 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.1 | 1.2 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.1 | 0.8 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.1 | 0.3 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.1 | 0.2 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.1 | 0.3 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.1 | 0.2 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 0.0 | 0.4 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.2 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.0 | 0.9 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.0 | 1.1 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.0 | 0.3 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.0 | 0.2 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.0 | 0.1 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
| 0.0 | 0.2 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.0 | 0.3 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.5 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.4 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.5 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 0.3 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.4 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 1.0 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.3 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 0.1 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 0.2 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.0 | 0.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.1 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.0 | 0.3 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.2 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.5 | GO:0016505 | peptidase activator activity involved in apoptotic process(GO:0016505) |
| 0.0 | 1.8 | GO:0098531 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.0 | 0.1 | GO:0001849 | complement component C1q binding(GO:0001849) virion binding(GO:0046790) |
| 0.0 | 0.1 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 0.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.3 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.0 | 0.0 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.0 | 0.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 3.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.3 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 0.9 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 3.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.8 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 1.9 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 1.4 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.0 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.4 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 0.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.4 | REACTOME PI3K EVENTS IN ERBB4 SIGNALING | Genes involved in PI3K events in ERBB4 signaling |
| 0.0 | 0.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.2 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |