ISMARA results: HMBOX1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMBOX1

Z-value: 0.86

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Transcription factors associated with HMBOX1

Gene Symbol	Gene ID	Gene Info
HMBOX1 Ensembl NCBI GeneCards UniProt	ENSG00000147421.13	homeobox containing 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HMBOX1	hg19_v2_chr8_+_28747884_28747938	0.12	6.1e-01	Click!

Activity profile of HMBOX1 motif

Sorted Z-values of HMBOX1 motif

No targets for HMBOX1

Network of associatons between targets according to the STRING database.

First level regulatory network of HMBOX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0032411	positive regulation of transporter activity(GO:0032411)
0.1	2.0	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	2.0	GO:0043555	regulation of translation in response to stress(GO:0043555)
0.0	1.6	GO:0048286	lung alveolus development(GO:0048286)
0.0	1.4	GO:1902751	positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.4	1.2	GO:0045720	negative regulation of integrin biosynthetic process(GO:0045720)
0.4	1.1	GO:0007037	vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.2	1.1	GO:0043323	regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.2	0.9	GO:0046900	tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0	0.9	GO:0000185	activation of MAPKKK activity(GO:0000185)

Showing 1 to 10 of 79 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	1.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	1.1	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.9	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	0.7	GO:0042382	paraspeckles(GO:0042382)
0.0	0.6	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1	0.4	GO:1990298	mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.1	0.4	GO:0005715	late recombination nodule(GO:0005715)
0.1	0.4	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	0.4	GO:0097513	myosin II filament(GO:0097513)

Showing 1 to 10 of 32 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	1.9	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	1.7	GO:0019894	kinesin binding(GO:0019894)
0.0	1.6	GO:0050699	WW domain binding(GO:0050699)
0.0	1.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2	1.2	GO:0004882	androgen receptor activity(GO:0004882)
0.1	1.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.9	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.9	GO:0008242	omega peptidase activity(GO:0008242)
0.1	0.8	GO:0018636	phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)

Showing 1 to 10 of 64 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
2.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
1.8	PID ATR PATHWAY	ATR signaling pathway
1.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.8	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.4	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.4	PID IL3 PATHWAY	IL3-mediated signaling events

Showing 1 to 8 of 8 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	1.7	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.4	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	1.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	1.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.7	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.6	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.6	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.6	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	0.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects

Showing 1 to 10 of 21 entries

Results for HMBOX1

Z-value: 0.86

Motif logo

Transcription factors associated with HMBOX1

Activity-expression correlation:

Activity profile of HMBOX1 motif

Sorted Z-values of HMBOX1 motif

No targets for HMBOX1

Network of associatons between targets according to the STRING database.

First level regulatory network of HMBOX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: