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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA1

Z-value: 2.13

Motif logo

Transcription factors associated with HMGA1

Gene Symbol Gene ID Gene Info
ENSG00000137309.15 high mobility group AT-hook 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA1hg19_v2_chr6_+_34204642_342046640.165.0e-01Click!

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.7 2.0 GO:0046680 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.6 1.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.4 4.9 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.4 1.3 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.4 1.3 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.4 7.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 1.1 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.3 1.0 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.3 1.9 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.3 3.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.3 0.9 GO:0045062 extrathymic T cell selection(GO:0045062)
0.3 1.4 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.3 1.0 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.3 11.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 1.0 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 0.7 GO:0032203 telomere formation via telomerase(GO:0032203)
0.2 3.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 2.4 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.2 1.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 1.6 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.2 1.9 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.2 1.8 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 0.9 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.2 0.6 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.2 1.5 GO:1902896 terminal web assembly(GO:1902896)
0.2 0.8 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.2 0.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 1.4 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.2 0.8 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.2 1.8 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.2 1.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 3.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 2.3 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.2 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 0.6 GO:1902512 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.2 0.7 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 1.6 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 0.7 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 2.8 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 1.3 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.2 1.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 0.5 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1 1.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 1.3 GO:0035494 SNARE complex disassembly(GO:0035494)
0.1 0.4 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.1 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 0.7 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.8 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.1 0.7 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.1 0.8 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 0.9 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 1.5 GO:0019530 taurine metabolic process(GO:0019530)
0.1 0.8 GO:0001880 Mullerian duct regression(GO:0001880)
0.1 2.0 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 0.6 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 0.4 GO:0042245 RNA repair(GO:0042245)
0.1 4.4 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 1.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 0.4 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.7 GO:0015692 lead ion transport(GO:0015692)
0.1 0.6 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.1 0.9 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.8 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 0.4 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 1.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 0.3 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1 1.6 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 1.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 2.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.3 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.7 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.1 0.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.8 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 0.6 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 1.1 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 1.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 1.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.3 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.5 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 0.3 GO:1904106 protein localization to microvillus(GO:1904106)
0.1 1.9 GO:0009650 UV protection(GO:0009650)
0.1 2.3 GO:0006825 copper ion transport(GO:0006825)
0.1 0.8 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 1.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.3 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.1 0.4 GO:0039650 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.1 0.8 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.2 GO:0033488 cholesterol biosynthetic process via 24,25-dihydrolanosterol(GO:0033488)
0.1 0.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 1.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 0.4 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.8 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.3 GO:0060023 soft palate development(GO:0060023)
0.1 0.9 GO:0007144 female meiosis I(GO:0007144)
0.1 1.0 GO:0008037 cell recognition(GO:0008037)
0.1 2.3 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 0.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 1.6 GO:0034116 positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.1 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 2.1 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.7 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 1.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.4 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)
0.1 0.2 GO:0006429 glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429)
0.1 0.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.5 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1 0.4 GO:0002329 pre-B cell differentiation(GO:0002329)
0.1 0.9 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 0.4 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.1 0.7 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.3 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.1 4.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.5 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.5 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.5 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.2 GO:0035711 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) T-helper 1 cell activation(GO:0035711)
0.0 0.3 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.4 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 3.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.0 0.5 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.2 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 1.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515)
0.0 0.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.5 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0036111 very long-chain fatty-acyl-CoA metabolic process(GO:0036111)
0.0 0.2 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.5 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.9 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 1.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 1.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.4 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:1903824 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.0 0.1 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0 1.7 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 1.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0097338 response to clozapine(GO:0097338)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.3 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.2 GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) negative regulation of cholesterol efflux(GO:0090370)
0.0 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.4 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 1.8 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.4 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.6 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 1.0 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.3 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.8 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.3 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 1.3 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.8 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 1.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.3 GO:1903874 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.2 GO:0002679 respiratory burst involved in defense response(GO:0002679) negative regulation of triglyceride catabolic process(GO:0010897)
0.0 0.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.7 GO:0010447 response to acidic pH(GO:0010447)
0.0 1.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.9 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 1.5 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.6 GO:0033622 integrin activation(GO:0033622)
0.0 0.2 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.6 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.2 GO:0016139 glycoside catabolic process(GO:0016139)
0.0 0.7 GO:0043066 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.6 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.0 0.3 GO:0006887 exocytosis(GO:0006887)
0.0 0.3 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 1.3 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.6 GO:0006012 galactose metabolic process(GO:0006012)
0.0 2.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.4 GO:0042246 tissue regeneration(GO:0042246)
0.0 0.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.5 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.6 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.0 GO:1904398 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) positive regulation of neuromuscular junction development(GO:1904398)
0.0 0.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.6 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.1 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
0.0 0.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.5 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.1 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.0 0.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 1.8 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 2.7 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.3 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.4 GO:0043586 tongue development(GO:0043586)
0.0 0.3 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 2.9 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 0.8 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 1.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.9 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0 0.5 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.2 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.0 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.0 0.4 GO:2001222 regulation of neuron migration(GO:2001222)
0.0 0.2 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.3 GO:0036508 protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
0.0 1.5 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.7 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.0 0.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 1.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0034776 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)
0.0 0.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.0 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.3 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 2.4 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 0.4 GO:0033048 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of chromosome segregation(GO:0051985) negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 2.3 GO:0051028 mRNA transport(GO:0051028)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.3 1.0 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.3 4.4 GO:0005577 fibrinogen complex(GO:0005577)
0.3 0.8 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.3 1.6 GO:1990246 uniplex complex(GO:1990246)
0.3 4.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 1.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 1.5 GO:1990357 terminal web(GO:1990357)
0.2 1.8 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.2 0.5 GO:0071821 FANCM-MHF complex(GO:0071821)
0.2 1.0 GO:0000799 nuclear condensin complex(GO:0000799)
0.2 1.0 GO:0097149 centralspindlin complex(GO:0097149)
0.2 1.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 2.1 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.4 GO:0034455 t-UTP complex(GO:0034455)
0.1 2.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 2.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.7 GO:0070826 paraferritin complex(GO:0070826)
0.1 4.7 GO:0000145 exocyst(GO:0000145)
0.1 0.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.1 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.8 GO:0032437 cuticular plate(GO:0032437)
0.1 0.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 0.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.7 GO:0036021 endolysosome lumen(GO:0036021)
0.1 1.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 2.0 GO:0016342 catenin complex(GO:0016342)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.1 1.2 GO:0008091 spectrin(GO:0008091)
0.1 2.6 GO:0043194 axon initial segment(GO:0043194)
0.1 0.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.3 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.1 0.7 GO:0005827 polar microtubule(GO:0005827)
0.1 0.3 GO:0002079 inner acrosomal membrane(GO:0002079)
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.9 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 1.0 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 2.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 6.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.6 GO:0061574 ASAP complex(GO:0061574)
0.1 0.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.8 GO:0005915 zonula adherens(GO:0005915)
0.0 2.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0071439 clathrin complex(GO:0071439)
0.0 0.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.9 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 1.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 3.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0042587 glycogen granule(GO:0042587)
0.0 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 1.2 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.6 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 6.4 GO:0043197 dendritic spine(GO:0043197)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 2.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 2.0 GO:0005657 replication fork(GO:0005657)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 1.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.0 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 3.3 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0015030 Cajal body(GO:0015030)
0.0 3.4 GO:0005795 Golgi stack(GO:0005795)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 2.7 GO:0030496 midbody(GO:0030496)
0.0 1.4 GO:0099513 polymeric cytoskeletal fiber(GO:0099513)
0.0 0.0 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 1.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.5 2.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.4 4.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 11.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.4 1.1 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.4 1.1 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.3 1.0 GO:0033677 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) DNA/RNA helicase activity(GO:0033677)
0.3 1.0 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.3 2.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 1.2 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.3 0.8 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.3 1.8 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.2 0.7 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.2 0.9 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 0.9 GO:0005018 platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.2 0.6 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.2 0.6 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.2 2.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 1.8 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 5.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.6 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.1 0.7 GO:0031208 POZ domain binding(GO:0031208)
0.1 1.0 GO:0015057 thrombin receptor activity(GO:0015057)
0.1 1.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 1.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.6 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.7 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.4 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 1.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 3.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.6 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 2.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.3 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.1 1.5 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.5 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 2.0 GO:0008494 translation activator activity(GO:0008494)
0.1 2.0 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.0 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.4 GO:0035514 DNA demethylase activity(GO:0035514)
0.1 1.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.6 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.5 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.3 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.4 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.2 GO:0008398 sterol 14-demethylase activity(GO:0008398)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.8 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.6 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 1.7 GO:0032183 SUMO binding(GO:0032183)
0.1 1.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 0.8 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.2 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.1 1.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.6 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.4 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.2 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.1 2.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.6 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 1.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.5 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.3 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.0 2.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.7 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 2.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0086039 lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039)
0.0 0.7 GO:0000150 recombinase activity(GO:0000150)
0.0 3.2 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 1.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0042731 PH domain binding(GO:0042731)
0.0 2.9 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0033989 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594)
0.0 0.3 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0 0.9 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.9 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0001601 peptide YY receptor activity(GO:0001601)
0.0 1.5 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.8 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 1.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 3.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.5 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.5 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.2 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 1.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 4.5 GO:0051087 chaperone binding(GO:0051087)
0.0 1.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 2.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.0 GO:0019863 IgE binding(GO:0019863)
0.0 1.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.4 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 1.4 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 1.9 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0030506 ankyrin binding(GO:0030506)
0.0 1.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 1.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.4 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.8 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 1.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 1.0 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.8 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.4 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.9 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 8.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 6.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 5.0 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 0.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 4.2 PID AURORA B PATHWAY Aurora B signaling
0.0 3.5 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.9 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.6 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 2.3 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.8 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.6 PID INSULIN PATHWAY Insulin Pathway
0.0 1.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 2.9 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.2 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.8 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.2 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 11.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 3.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 4.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.0 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 5.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 0.8 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 0.8 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 4.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 11.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.9 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.5 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 2.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.9 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 5.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.9 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.5 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 3.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.3 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.1 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 1.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.8 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 1.4 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.8 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.8 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0 1.0 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.7 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 3.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.0 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane