ISMARA results: HMGA1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HMGA1

Z-value: 2.13

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Transcription factors associated with HMGA1

Gene Symbol	Gene ID	Gene Info
HMGA1 Ensembl NCBI GeneCards UniProt	ENSG00000137309.15	high mobility group AT-hook 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HMGA1	hg19_v2_chr6_+_34204642_34204664	0.16	5.0e-01	Click!

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

No targets for HMGA1

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.4	7.2	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.4	4.9	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1	4.5	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.1	4.4	GO:0043555	regulation of translation in response to stress(GO:0043555)
0.9	3.7	GO:2000863	positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.2	3.4	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	3.3	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.3	3.1	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2	3.1	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)

Showing 1 to 10 of 272 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0043197	dendritic spine(GO:0043197)
0.1	6.1	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	4.7	GO:0000145	exocyst(GO:0000145)
0.3	4.4	GO:0005577	fibrinogen complex(GO:0005577)
0.3	4.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	3.4	GO:0005795	Golgi stack(GO:0005795)
0.0	3.3	GO:0005814	centriole(GO:0005814)
0.0	3.1	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	2.7	GO:0030496	midbody(GO:0030496)
0.1	2.6	GO:0043194	axon initial segment(GO:0043194)

Showing 1 to 10 of 113 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	11.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.2	5.9	GO:0000030	mannosyltransferase activity(GO:0000030)
0.0	4.5	GO:0051087	chaperone binding(GO:0051087)
0.4	4.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	3.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	3.2	GO:0042169	SH2 domain binding(GO:0042169)
0.1	3.0	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	2.9	GO:0019894	kinesin binding(GO:0019894)
0.1	2.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	2.6	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)

Showing 1 to 10 of 173 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	6.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	5.6	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	5.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	4.2	PID AURORA B PATHWAY	Aurora B signaling
0.0	3.5	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	2.9	PID NOTCH PATHWAY	Notch signaling pathway
0.0	2.6	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	2.5	PID PLK1 PATHWAY	PLK1 signaling events
0.0	2.3	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	11.9	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	11.0	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	5.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	5.0	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	4.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	4.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.2	3.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	3.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	3.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	3.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Showing 1 to 10 of 69 entries

Results for HMGA1

Z-value: 2.13

Motif logo

Transcription factors associated with HMGA1

Activity-expression correlation:

Activity profile of HMGA1 motif

Sorted Z-values of HMGA1 motif

No targets for HMGA1

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: