ISMARA results: HNF1A

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HNF1A_HNF1B

Z-value: 8.91

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol	Gene ID	Gene Info
HNF1A Ensembl NCBI GeneCards UniProt	ENSG00000135100.13	HNF1 homeobox A
HNF1B Ensembl NCBI GeneCards UniProt	ENSG00000108753.8	HNF1 homeobox B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF1A	hg19_v2_chr12_+_121416340_121416371	0.94	5.9e-10	Click!
HNF1B	hg19_v2_chr17_-_36105009_36105060	0.82	1.1e-05	Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

No targets for HNF1A_HNF1B

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.9	110.5	GO:0043152	induction of bacterial agglutination(GO:0043152)
8.1	105.9	GO:0019375	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
13.3	79.7	GO:1903412	response to bile acid(GO:1903412)
4.3	51.4	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
4.8	48.3	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
1.4	47.1	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
14.0	41.9	GO:0016999	antibiotic metabolic process(GO:0016999)
6.1	36.9	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.3	36.5	GO:0032411	positive regulation of transporter activity(GO:0032411)
5.2	36.4	GO:0010133	proline catabolic process to glutamate(GO:0010133)

Showing 1 to 10 of 115 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.4	132.0	GO:0005577	fibrinogen complex(GO:0005577)
0.1	105.6	GO:0000139	Golgi membrane(GO:0000139)
0.1	79.3	GO:0030133	transport vesicle(GO:0030133)
0.1	58.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	48.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	47.4	GO:0005654	nucleoplasm(GO:0005654)
2.6	46.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	40.3	GO:0005759	mitochondrial matrix(GO:0005759)
3.3	39.9	GO:0046581	intercellular canaliculus(GO:0046581)
4.6	36.9	GO:0005579	membrane attack complex(GO:0005579)

Showing 1 to 10 of 64 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.8	105.9	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
6.6	79.7	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.4	70.6	GO:0051087	chaperone binding(GO:0051087)
3.4	47.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
9.4	46.8	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.8	46.5	GO:0005504	fatty acid binding(GO:0005504)
2.2	41.1	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
1.3	37.6	GO:0017081	chloride channel regulator activity(GO:0017081)
9.1	36.4	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.8	36.1	GO:0008009	chemokine activity(GO:0008009)

Showing 1 to 10 of 97 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	113.5	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.9	83.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	79.2	PID FGF PATHWAY	FGF signaling pathway
0.1	35.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	29.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	29.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.4	25.4	PID CD40 PATHWAY	CD40/CD40L signaling
0.4	16.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	16.2	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	13.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Showing 1 to 10 of 22 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.8	117.0	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
1.5	105.9	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
4.7	79.7	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
1.5	78.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
2.0	51.9	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.1	48.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.8	41.1	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.6	31.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3	30.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.4	28.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Showing 1 to 10 of 33 entries

Results for HNF1A_HNF1B

Z-value: 8.91

Motif logo

Transcription factors associated with HNF1A_HNF1B

Activity-expression correlation:

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

No targets for HNF1A_HNF1B

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: