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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HNF4A
Z-value: 3.16
Motif logo
Transcription factors associated with HNF4A
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HNF4A
|
ENSG00000101076.12 | hepatocyte nuclear factor 4 alpha |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HNF4A | hg19_v2_chr20_+_43029911_43029941 | 0.94 | 7.5e-10 | Click! |
Activity profile of HNF4A motif
Sorted Z-values of HNF4A motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HNF4A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 24.5 | GO:0035565 | regulation of pronephros size(GO:0035565) |
| 2.0 | 6.0 | GO:0045720 | negative regulation of integrin biosynthetic process(GO:0045720) |
| 1.6 | 4.9 | GO:0032203 | telomere formation via telomerase(GO:0032203) |
| 1.6 | 3.2 | GO:0097187 | dentinogenesis(GO:0097187) |
| 1.4 | 10.0 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 1.1 | 3.3 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 1.1 | 9.5 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 1.0 | 3.1 | GO:0060061 | Spemann organizer formation(GO:0060061) |
| 1.0 | 3.1 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 1.0 | 4.8 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.8 | 9.1 | GO:0019344 | cysteine biosynthetic process(GO:0019344) |
| 0.7 | 3.6 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.7 | 2.1 | GO:0061727 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.7 | 2.7 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 0.6 | 4.2 | GO:0015798 | myo-inositol transport(GO:0015798) |
| 0.6 | 1.8 | GO:1901842 | negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.6 | 2.3 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.6 | 2.3 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.6 | 3.9 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.5 | 2.6 | GO:0019303 | D-ribose catabolic process(GO:0019303) |
| 0.5 | 2.0 | GO:0046452 | dihydrofolate metabolic process(GO:0046452) |
| 0.4 | 3.2 | GO:0015811 | L-cystine transport(GO:0015811) |
| 0.4 | 3.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.3 | 1.3 | GO:1904106 | protein localization to microvillus(GO:1904106) |
| 0.3 | 14.0 | GO:0036499 | PERK-mediated unfolded protein response(GO:0036499) |
| 0.3 | 9.4 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.3 | 1.0 | GO:1901253 | negative regulation of intracellular transport of viral material(GO:1901253) |
| 0.3 | 3.1 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.3 | 2.2 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 0.3 | 1.2 | GO:0072302 | negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302) |
| 0.3 | 3.0 | GO:0050747 | positive regulation of lipoprotein metabolic process(GO:0050747) |
| 0.3 | 9.2 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.3 | 2.5 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.3 | 1.9 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.3 | 0.8 | GO:1903964 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.3 | 3.0 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.2 | 1.7 | GO:0008295 | spermidine biosynthetic process(GO:0008295) primary amino compound biosynthetic process(GO:1901162) |
| 0.2 | 1.0 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.2 | 2.2 | GO:0046874 | quinolinate metabolic process(GO:0046874) |
| 0.2 | 2.7 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.2 | 1.0 | GO:0072334 | UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334) |
| 0.2 | 0.7 | GO:1904640 | response to methionine(GO:1904640) |
| 0.2 | 1.6 | GO:0030997 | regulation of centriole-centriole cohesion(GO:0030997) |
| 0.2 | 4.3 | GO:0016559 | peroxisome fission(GO:0016559) |
| 0.2 | 4.2 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.2 | 2.2 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.2 | 0.8 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.2 | 0.9 | GO:1904970 | brush border assembly(GO:1904970) |
| 0.2 | 1.6 | GO:2000809 | positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.2 | 0.9 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.2 | 0.9 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 3.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 2.8 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 3.7 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.1 | 2.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 6.0 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 1.1 | GO:1904338 | regulation of dopaminergic neuron differentiation(GO:1904338) |
| 0.1 | 0.5 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.1 | 0.4 | GO:0043418 | homocysteine catabolic process(GO:0043418) |
| 0.1 | 0.7 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 0.1 | 0.7 | GO:0098912 | membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.1 | 0.4 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 4.9 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.1 | 1.6 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 3.1 | GO:0003298 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.2 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.1 | 0.6 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 0.7 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.1 | 1.1 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.1 | 2.0 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 0.5 | GO:0001826 | inner cell mass cell differentiation(GO:0001826) |
| 0.1 | 0.4 | GO:0019477 | L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440) |
| 0.1 | 0.9 | GO:0032006 | regulation of TOR signaling(GO:0032006) |
| 0.0 | 0.1 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.0 | 0.5 | GO:0017062 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 3.2 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 4.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 0.3 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.0 | 1.0 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 0.3 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.0 | 0.5 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.0 | 1.8 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.0 | 0.3 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.0 | 3.3 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 4.5 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.7 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 1.3 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.0 | 1.8 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.0 | 0.1 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.0 | 1.3 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.0 | 1.2 | GO:1900078 | positive regulation of cellular response to insulin stimulus(GO:1900078) |
| 0.0 | 1.2 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 0.9 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 0.4 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.0 | 0.3 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.0 | 0.2 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.0 | 9.3 | GO:0032259 | methylation(GO:0032259) |
| 0.0 | 0.3 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.0 | 0.0 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.0 | 0.0 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 0.0 | 0.2 | GO:0010990 | regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) |
| 0.0 | 3.9 | GO:0010038 | response to metal ion(GO:0010038) |
| 0.0 | 0.2 | GO:0034433 | steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.3 | 2.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 3.1 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.2 | 20.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 2.2 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 1.6 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 4.9 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 0.8 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.1 | 0.3 | GO:0001534 | radial spoke(GO:0001534) |
| 0.1 | 3.3 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 1.5 | GO:0005903 | brush border(GO:0005903) |
| 0.1 | 10.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 5.9 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 0.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 1.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 1.1 | GO:0036038 | MKS complex(GO:0036038) |
| 0.0 | 3.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 2.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 17.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.5 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 8.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 7.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 1.2 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 1.3 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 3.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 2.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 10.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 1.5 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 3.0 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.0 | 2.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 14.0 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 1.0 | 3.0 | GO:0080101 | phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101) |
| 1.0 | 3.9 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.8 | 3.3 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.7 | 3.6 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.7 | 2.1 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.6 | 6.0 | GO:0005497 | androgen binding(GO:0005497) |
| 0.6 | 4.2 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.5 | 4.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.5 | 4.6 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.5 | 9.1 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.5 | 4.2 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.4 | 2.8 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.4 | 2.0 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.4 | 3.2 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.3 | 3.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.3 | 2.0 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.3 | 2.3 | GO:0050294 | steroid sulfotransferase activity(GO:0050294) |
| 0.3 | 4.8 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.3 | 3.0 | GO:0030249 | cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249) |
| 0.3 | 2.5 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.3 | 5.0 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.3 | 1.6 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 1.0 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.2 | 1.2 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.2 | 6.0 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.2 | 1.0 | GO:0005459 | UDP-galactose transmembrane transporter activity(GO:0005459) |
| 0.2 | 9.4 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.2 | 0.7 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.2 | 1.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.2 | 2.2 | GO:0047623 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.2 | 5.4 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.2 | 1.0 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.2 | 0.8 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.2 | 7.9 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.2 | 1.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212) |
| 0.2 | 2.0 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 0.9 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.2 | 3.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.1 | 2.7 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 3.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.5 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.1 | 0.5 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.1 | 1.8 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 4.9 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.1 | 1.7 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.1 | 0.5 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.1 | 21.0 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 1.3 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.1 | 1.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 0.7 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.1 | 0.8 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.1 | 20.6 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 4.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 0.3 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.1 | 3.1 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.9 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 0.4 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.1 | 0.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 0.2 | GO:0034736 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.1 | 3.8 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 1.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.4 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.1 | 2.6 | GO:0019200 | carbohydrate kinase activity(GO:0019200) |
| 0.1 | 4.9 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.1 | GO:0008480 | sarcosine dehydrogenase activity(GO:0008480) |
| 0.0 | 0.9 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.2 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 1.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 0.3 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.0 | 1.8 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 1.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 1.9 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 3.2 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 2.5 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.8 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 9.5 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 0.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.0 | 0.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.5 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 11.7 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 0.0 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
| 0.0 | 0.7 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 1.0 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 6.0 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.1 | 6.0 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 3.1 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 4.1 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 4.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 3.6 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 2.0 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 9.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.6 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 2.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.2 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 34.7 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.5 | 14.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.3 | 5.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 8.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 9.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 3.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 3.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 1.9 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 4.9 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 3.0 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 5.2 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 2.0 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 2.7 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 2.2 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 4.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 4.2 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 2.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.1 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.1 | 0.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 2.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 1.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.2 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 3.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 0.7 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 2.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.6 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.0 | 1.8 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 0.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.9 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 4.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 3.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 0.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 6.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.0 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 2.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.1 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 0.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 1.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 3.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 0.9 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 0.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |