ISMARA results: HNF4A

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HNF4A

Z-value: 3.16

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Transcription factors associated with HNF4A

Gene Symbol	Gene ID	Gene Info
HNF4A Ensembl NCBI GeneCards UniProt	ENSG00000101076.12	hepatocyte nuclear factor 4 alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF4A	hg19_v2_chr20_+_43029911_43029941	0.94	7.5e-10	Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

No targets for HNF4A

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.1	24.5	GO:0035565	regulation of pronephros size(GO:0035565)
0.3	14.0	GO:0036499	PERK-mediated unfolded protein response(GO:0036499)
1.4	10.0	GO:0061113	pancreas morphogenesis(GO:0061113)
1.1	9.5	GO:0006572	tyrosine catabolic process(GO:0006572)
0.3	9.4	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	9.3	GO:0032259	methylation(GO:0032259)
0.3	9.2	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.8	9.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
2.0	6.0	GO:0045720	negative regulation of integrin biosynthetic process(GO:0045720)
0.1	6.0	GO:0042572	retinol metabolic process(GO:0042572)

Showing 1 to 10 of 103 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.5	GO:0016459	myosin complex(GO:0016459)
0.0	17.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	10.5	GO:0005925	focal adhesion(GO:0005925)
0.1	10.2	GO:0005796	Golgi lumen(GO:0005796)
0.0	8.6	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	7.6	GO:0005667	transcription factor complex(GO:0005667)
0.1	5.9	GO:0031526	brush border membrane(GO:0031526)
0.1	4.9	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.5	4.8	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.1	3.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)

Showing 1 to 10 of 38 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.0	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	20.6	GO:0003774	motor activity(GO:0003774)
1.0	14.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	11.7	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	9.5	GO:0008168	methyltransferase activity(GO:0008168)
0.2	9.4	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.5	9.1	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	7.9	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.6	6.0	GO:0005497	androgen binding(GO:0005497)
0.2	6.0	GO:0004745	retinol dehydrogenase activity(GO:0004745)

Showing 1 to 10 of 86 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	38.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	9.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	6.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	6.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.1	4.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	4.1	PID REELIN PATHWAY	Reelin signaling pathway
0.0	3.6	PID ENDOTHELIN PATHWAY	Endothelins
0.0	3.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	3.6	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.1	3.1	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 15 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	34.7	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.5	14.0	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	9.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	8.4	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	6.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.3	5.4	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	5.2	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1	4.9	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.1	4.8	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	4.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport

Showing 1 to 10 of 47 entries

Results for HNF4A

Z-value: 3.16

Motif logo

Transcription factors associated with HNF4A

Activity-expression correlation:

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

No targets for HNF4A

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: