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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HOXA1
Z-value: 1.94
Motif logo
Transcription factors associated with HOXA1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HOXA1
|
ENSG00000105991.7 | homeobox A1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA1 | hg19_v2_chr7_-_27135591_27135658 | -0.81 | 1.5e-05 | Click! |
Activity profile of HOXA1 motif
Sorted Z-values of HOXA1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 16.7 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 1.9 | 5.8 | GO:2000437 | monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437) |
| 1.6 | 9.8 | GO:0061143 | alveolar primary septum development(GO:0061143) |
| 1.4 | 4.1 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 1.0 | 5.1 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.9 | 4.7 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.6 | 8.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.5 | 1.4 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.5 | 1.4 | GO:0060061 | Spemann organizer formation(GO:0060061) |
| 0.4 | 1.3 | GO:0032304 | negative regulation of icosanoid secretion(GO:0032304) |
| 0.4 | 1.3 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 0.4 | 1.2 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.4 | 1.9 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.3 | 1.0 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.3 | 2.4 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.3 | 1.7 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.3 | 1.3 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.3 | 0.9 | GO:2000824 | negative regulation of androgen receptor activity(GO:2000824) |
| 0.3 | 6.4 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.3 | 1.1 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 0.3 | 1.4 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.3 | 1.3 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.3 | 2.3 | GO:0055064 | chloride ion homeostasis(GO:0055064) |
| 0.2 | 1.2 | GO:0018262 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.2 | 4.8 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.2 | 1.5 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.2 | 0.8 | GO:1901594 | detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594) |
| 0.2 | 0.8 | GO:0090119 | vesicle-mediated cholesterol transport(GO:0090119) |
| 0.2 | 0.6 | GO:0051758 | homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758) |
| 0.2 | 1.6 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.2 | 0.5 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.2 | 2.7 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.2 | 3.2 | GO:0090520 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.1 | 0.7 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.1 | 0.7 | GO:0036371 | protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.5 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 0.1 | 0.8 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.1 | 1.1 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.1 | 0.4 | GO:0042137 | sequestering of neurotransmitter(GO:0042137) |
| 0.1 | 0.4 | GO:0015680 | intracellular copper ion transport(GO:0015680) |
| 0.1 | 1.0 | GO:0021831 | embryonic olfactory bulb interneuron precursor migration(GO:0021831) |
| 0.1 | 0.5 | GO:0009224 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.1 | 1.1 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.1 | 0.8 | GO:0035624 | receptor transactivation(GO:0035624) |
| 0.1 | 0.2 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.1 | 0.3 | GO:0034130 | toll-like receptor 1 signaling pathway(GO:0034130) |
| 0.1 | 0.9 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.1 | 0.8 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.1 | 0.7 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.1 | 0.4 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 0.1 | 2.1 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.1 | 1.3 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 0.3 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.1 | 0.5 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.1 | 0.6 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.1 | 0.4 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.1 | 0.7 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 0.6 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.1 | 0.7 | GO:0090043 | regulation of tubulin deacetylation(GO:0090043) |
| 0.1 | 0.1 | GO:0010512 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) |
| 0.1 | 0.5 | GO:0035989 | tendon development(GO:0035989) |
| 0.1 | 0.2 | GO:0050894 | determination of affect(GO:0050894) |
| 0.1 | 0.6 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.1 | 0.3 | GO:1990022 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 0.1 | 0.6 | GO:0006049 | UDP-N-acetylglucosamine catabolic process(GO:0006049) |
| 0.1 | 0.9 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.1 | 0.8 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 1.0 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 0.8 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 0.1 | 0.4 | GO:0006499 | N-terminal protein myristoylation(GO:0006499) |
| 0.1 | 0.2 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623) |
| 0.0 | 0.5 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.0 | 0.3 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.0 | 0.3 | GO:0050803 | regulation of synapse structure or activity(GO:0050803) |
| 0.0 | 1.4 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.0 | 0.8 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.3 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.0 | 2.9 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.0 | 0.5 | GO:0042940 | D-amino acid transport(GO:0042940) |
| 0.0 | 0.2 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.0 | 0.1 | GO:0045554 | TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556) |
| 0.0 | 0.4 | GO:0021979 | hypothalamus cell differentiation(GO:0021979) |
| 0.0 | 0.2 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.0 | 0.2 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.0 | 0.3 | GO:0098912 | membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.0 | 0.4 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.0 | 0.6 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.0 | 0.1 | GO:0060005 | vestibular reflex(GO:0060005) |
| 0.0 | 1.0 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.0 | 0.3 | GO:0002857 | positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.4 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.0 | 0.2 | GO:1902952 | positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.0 | 0.8 | GO:0045109 | intermediate filament organization(GO:0045109) |
| 0.0 | 2.0 | GO:2000273 | positive regulation of receptor activity(GO:2000273) |
| 0.0 | 0.3 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.0 | 0.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 1.0 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 1.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.1 | GO:1904647 | response to rotenone(GO:1904647) |
| 0.0 | 0.5 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.0 | 1.3 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.4 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 2.2 | GO:0035690 | cellular response to drug(GO:0035690) |
| 0.0 | 2.3 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.4 | GO:1903874 | ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874) |
| 0.0 | 0.1 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.0 | 0.4 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 1.0 | GO:0097503 | sialylation(GO:0097503) |
| 0.0 | 0.9 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 0.8 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.0 | 0.3 | GO:0003356 | regulation of cilium beat frequency(GO:0003356) |
| 0.0 | 0.9 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 0.2 | GO:0072498 | embryonic skeletal joint development(GO:0072498) |
| 0.0 | 0.9 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.0 | 0.1 | GO:1903597 | negative regulation of gap junction assembly(GO:1903597) |
| 0.0 | 0.4 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 1.1 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 1.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.0 | 2.0 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.0 | 4.3 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.4 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 0.1 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) |
| 0.0 | 2.1 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 2.1 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.8 | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803) |
| 0.0 | 0.2 | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915) |
| 0.0 | 0.3 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.0 | 0.4 | GO:0021904 | dorsal/ventral neural tube patterning(GO:0021904) |
| 0.0 | 0.1 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.0 | 4.0 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 2.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.6 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.0 | 0.4 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.0 | GO:0051852 | disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873) |
| 0.0 | 0.7 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 0.1 | GO:1904220 | regulation of serine C-palmitoyltransferase activity(GO:1904220) |
| 0.0 | 0.7 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
| 0.0 | 0.1 | GO:0048845 | venous blood vessel morphogenesis(GO:0048845) |
| 0.0 | 2.3 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
| 0.0 | 0.5 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 16.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.5 | 2.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.5 | 1.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.3 | 1.7 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 0.8 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.1 | 0.6 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
| 0.1 | 1.4 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.1 | 0.3 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.1 | 0.5 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.1 | 0.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 0.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.1 | 0.5 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.1 | 0.2 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.0 | 4.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 3.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.7 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 0.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 2.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.7 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.4 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.0 | 2.0 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 1.8 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.0 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 1.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.9 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 13.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.2 | GO:0001740 | Barr body(GO:0001740) |
| 0.0 | 0.7 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.8 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 0.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 1.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.4 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.9 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.4 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 1.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.5 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 0.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 0.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.0 | 0.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.4 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.0 | 0.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 4.2 | GO:0000790 | nuclear chromatin(GO:0000790) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.0 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 1.2 | 4.8 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.7 | 2.0 | GO:0008969 | phosphohistidine phosphatase activity(GO:0008969) |
| 0.6 | 1.7 | GO:0070123 | transforming growth factor beta receptor activity, type III(GO:0070123) |
| 0.5 | 3.2 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.5 | 16.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 1.9 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) |
| 0.4 | 1.3 | GO:0097258 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.4 | 1.3 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.3 | 3.4 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 1.0 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.2 | 0.9 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.2 | 1.6 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.2 | 4.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 0.8 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.2 | 9.5 | GO:0051183 | vitamin transporter activity(GO:0051183) |
| 0.2 | 5.8 | GO:0005112 | Notch binding(GO:0005112) |
| 0.2 | 1.2 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.2 | 0.8 | GO:0047374 | methylumbelliferyl-acetate deacetylase activity(GO:0047374) |
| 0.2 | 1.1 | GO:0004127 | cytidylate kinase activity(GO:0004127) |
| 0.1 | 5.3 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 1.8 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 2.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 0.7 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 1.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 2.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 0.8 | GO:0097603 | temperature-gated ion channel activity(GO:0097603) |
| 0.1 | 2.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 0.6 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 1.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 0.4 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.1 | 0.4 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.1 | 0.8 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.1 | 0.4 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.1 | 0.7 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923) |
| 0.1 | 1.3 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 0.4 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.1 | 0.2 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
| 0.1 | 0.6 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 0.9 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.1 | 0.2 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.1 | 1.4 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.1 | 0.3 | GO:0035663 | Toll-like receptor 2 binding(GO:0035663) |
| 0.1 | 1.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.5 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.1 | 0.4 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.1 | 0.4 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 1.0 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.1 | 0.5 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.0 | 1.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.8 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 1.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.3 | GO:0001602 | pancreatic polypeptide receptor activity(GO:0001602) |
| 0.0 | 0.7 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.5 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.0 | 0.3 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.0 | 0.7 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 1.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 0.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.3 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 0.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.2 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
| 0.0 | 0.1 | GO:0051800 | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800) |
| 0.0 | 1.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 2.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.2 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.0 | 1.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.3 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.0 | 0.2 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.0 | 0.7 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 4.2 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.4 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.0 | 0.4 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 1.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.8 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.2 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 0.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.6 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.0 | 0.1 | GO:0004423 | iduronate-2-sulfatase activity(GO:0004423) |
| 0.0 | 0.9 | GO:1901682 | sulfur compound transmembrane transporter activity(GO:1901682) |
| 0.0 | 2.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.4 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.1 | GO:1990189 | peptide-serine-N-acetyltransferase activity(GO:1990189) |
| 0.0 | 0.6 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.0 | 0.4 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 2.6 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 0.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 1.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.1 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.0 | 0.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 1.2 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.1 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.0 | 0.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.1 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.3 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.1 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.0 | 0.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.3 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.1 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.0 | 0.1 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 0.0 | 0.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 19.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 7.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 1.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 3.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.0 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.6 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 6.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.2 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 1.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 0.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.4 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 2.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 4.1 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 1.9 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.1 | 17.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 5.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 1.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 0.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 0.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 5.9 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 2.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.7 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 7.0 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 1.4 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.0 | 2.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 2.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.5 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 0.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.7 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.0 | 0.4 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |