ISMARA results: HOXA1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA1

Z-value: 1.94

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Transcription factors associated with HOXA1

Gene Symbol	Gene ID	Gene Info
HOXA1 Ensembl NCBI GeneCards UniProt	ENSG00000105991.7	homeobox A1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXA1	hg19_v2_chr7_-_27135591_27135658	-0.81	1.5e-05	Click!

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

No targets for HOXA1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	16.7	GO:1902847	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.6	9.8	GO:0061143	alveolar primary septum development(GO:0061143)
0.6	8.5	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.3	6.4	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
1.9	5.8	GO:2000437	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
1.0	5.1	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.2	4.8	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.9	4.7	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	4.3	GO:0043488	regulation of mRNA stability(GO:0043488)
1.4	4.1	GO:0002121	inter-male aggressive behavior(GO:0002121)

Showing 1 to 10 of 140 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	16.7	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	13.9	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	4.4	GO:0043198	dendritic shaft(GO:0043198)
0.0	4.2	GO:0000790	nuclear chromatin(GO:0000790)
0.0	3.9	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	2.7	GO:0045171	intercellular bridge(GO:0045171)
0.5	2.4	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.0	2.0	GO:0097542	ciliary tip(GO:0097542)
0.0	1.9	GO:0031430	M band(GO:0031430)
0.0	1.8	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	16.7	GO:0051787	misfolded protein binding(GO:0051787)
0.2	9.5	GO:0051183	vitamin transporter activity(GO:0051183)
1.5	6.0	GO:0008112	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.2	5.8	GO:0005112	Notch binding(GO:0005112)
0.1	5.3	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
1.2	4.8	GO:0004796	thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2	4.8	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	4.2	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.3	3.4	GO:0097322	7SK snRNA binding(GO:0097322)
0.5	3.2	GO:0046624	sphingolipid transporter activity(GO:0046624)

Showing 1 to 10 of 104 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	7.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	6.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	3.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.1	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	2.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	2.4	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	2.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	2.0	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	7.0	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.0	5.9	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.1	5.4	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.1	4.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	2.8	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	2.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2	2.4	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.1	2.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	2.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)

Showing 1 to 10 of 30 entries

Results for HOXA1

Z-value: 1.94

Motif logo

Transcription factors associated with HOXA1

Activity-expression correlation:

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

No targets for HOXA1

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: