ISMARA results: HOXA10

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA10_HOXB9

Z-value: 0.56

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Transcription factors associated with HOXA10_HOXB9

Gene Symbol	Gene ID	Gene Info
HOXA10 Ensembl NCBI GeneCards UniProt	ENSG00000253293.3	homeobox A10
HOXB9 Ensembl NCBI GeneCards UniProt	ENSG00000170689.8	homeobox B9

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXB9	hg19_v2_chr17_-_46703826_46703845	-0.74	2.1e-04	Click!
HOXA10	hg19_v2_chr7_-_27213893_27213954	-0.69	7.4e-04	Click!

Activity profile of HOXA10_HOXB9 motif

Sorted Z-values of HOXA10_HOXB9 motif

No targets for HOXA10_HOXB9

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA10_HOXB9

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.2	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.6	1.9	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.4	1.6	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.5	1.5	GO:0060278	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.3	1.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0	0.9	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.8	GO:0018149	peptide cross-linking(GO:0018149)
0.1	0.7	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2	0.6	GO:0060490	orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.2	0.6	GO:0061713	neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0005605	basal lamina(GO:0005605)
0.0	2.0	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.2	1.6	GO:0097179	protease inhibitor complex(GO:0097179)
0.5	1.5	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0	1.2	GO:0001533	cornified envelope(GO:0001533)
0.1	0.7	GO:0043083	synaptic cleft(GO:0043083)
0.2	0.6	GO:0060187	cell pole(GO:0060187)
0.0	0.6	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	0.4	GO:1990032	parallel fiber(GO:1990032)
0.1	0.4	GO:0097169	AIM2 inflammasome complex(GO:0097169)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.2	1.5	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	1.1	GO:0089720	caspase binding(GO:0089720)
0.2	0.7	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.1	0.6	GO:0061714	folic acid receptor activity(GO:0061714)
0.0	0.6	GO:0050700	CARD domain binding(GO:0050700)
0.2	0.5	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1	0.5	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0	0.5	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.5	GO:0070324	thyroid hormone binding(GO:0070324)

Showing 1 to 10 of 52 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
1.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
1.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
1.3	PID ALK1 PATHWAY	ALK1 signaling events
1.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.9	PID TRAIL PATHWAY	TRAIL signaling pathway
0.7	PID IL1 PATHWAY	IL1-mediated signaling events
0.5	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	ST STAT3 PATHWAY	STAT3 Pathway
0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.5	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.1	1.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.8	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.7	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.5	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors

Showing 1 to 8 of 8 entries

Results for HOXA10_HOXB9

Z-value: 0.56

Motif logo

Transcription factors associated with HOXA10_HOXB9

Activity-expression correlation:

Activity profile of HOXA10_HOXB9 motif

Sorted Z-values of HOXA10_HOXB9 motif

No targets for HOXA10_HOXB9

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA10_HOXB9

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: