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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA13

Z-value: 0.70

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Transcription factors associated with HOXA13

Gene Symbol Gene ID Gene Info
ENSG00000106031.6 homeobox A13

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA13hg19_v2_chr7_-_27239703_272397250.802.4e-05Click!

Activity profile of HOXA13 motif

Sorted Z-values of HOXA13 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA13

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.2 0.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.2 0.8 GO:0097045 phosphatidylserine exposure on blood platelet(GO:0097045)
0.2 0.6 GO:0008355 olfactory learning(GO:0008355)
0.1 0.4 GO:0034059 response to anoxia(GO:0034059) positive regulation of penile erection(GO:0060406)
0.1 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.0 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.5 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.4 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.4 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.4 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.1 0.3 GO:1904479 cellular response to bile acid(GO:1903413) negative regulation of intestinal absorption(GO:1904479) response to iron ion starvation(GO:1990641)
0.1 0.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.4 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.3 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.1 0.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.3 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 1.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 0.4 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1 0.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 0.4 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.3 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.3 GO:0010157 response to chlorate(GO:0010157)
0.1 0.2 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.2 GO:1902824 positive regulation of late endosome to lysosome transport(GO:1902824)
0.1 0.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.2 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.0 0.4 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.0 0.2 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.4 GO:0003190 atrioventricular valve formation(GO:0003190)
0.0 0.1 GO:0097051 establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.0 0.4 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 2.3 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.3 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.1 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0090212 vitamin E metabolic process(GO:0042360) regulation of establishment of blood-brain barrier(GO:0090210) negative regulation of establishment of blood-brain barrier(GO:0090212)
0.0 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.8 GO:0007099 centriole replication(GO:0007099)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.4 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 1.1 GO:0043486 histone exchange(GO:0043486)
0.0 0.1 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.0 GO:0009826 unidimensional cell growth(GO:0009826)
0.0 0.1 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0006235 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.5 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.0 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.0 0.1 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.4 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.5 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.3 GO:1905145 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 0.1 GO:0035799 ureter maturation(GO:0035799)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0007289 spermatid nucleus differentiation(GO:0007289)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 1.0 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.5 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.8 GO:0000796 condensin complex(GO:0000796)
0.1 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 1.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0016600 flotillin complex(GO:0016600)
0.0 0.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.3 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.0 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3 0.9 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.1 0.4 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.1 1.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.6 GO:0050436 microfibril binding(GO:0050436)
0.1 0.3 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.1 0.3 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.3 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.1 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 0.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.3 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.4 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.1 0.3 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 0.2 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)
0.1 0.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.4 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0005119 smoothened binding(GO:0005119)
0.0 0.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.4 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.7 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.0 0.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.7 GO:0019894 kinesin binding(GO:0019894)
0.0 0.2 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.1 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID AURORA B PATHWAY Aurora B signaling
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 1.0 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling