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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXA4

Z-value: 0.61

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
ENSG00000197576.9 homeobox A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27170352_271704180.165.0e-01Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.0 0.2 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.1 GO:0042214 terpene metabolic process(GO:0042214)
0.0 0.1 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.0 0.1 GO:2000646 lipid transport involved in lipid storage(GO:0010877) positive regulation of receptor catabolic process(GO:2000646)
0.0 0.3 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0071893 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.3 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.1 GO:0035038 female pronucleus assembly(GO:0035038)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.0 GO:1905069 allantois development(GO:1905069)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.0 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.3 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation